Results 141 to 150 of about 498,931 (351)

Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis [PDF]

, 2017
Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding atypical chemokine receptor 1 (ACKR1).
Megens, Remco T. A., Artinger, K., Duchene, Johan, Rot, Antal, Rot, A, Bianchini, Mariaelvy, von Andrian, Ulrich H., Caamano, J., von Andrian, UH, Aude Thiriot, Weber, Christian, Thiriot, Aude, Casanova-Acebes, M., Weber, C, Johan Duchene, S Leah Etheridge, Casanova-Acebes, Maria, Rot, A., Caamano, J, Megens, RTA, Nitz, K., Remco T A Megens, Moss, Paul; id_orcid, Eller, Kathrin, Etheridge, S.L., von Andrian, U.H., Hidalgo, A., Hub, E, Moss, Paul, Duchene, J, Megens, R.T.A., Ulrich H von Andrian, Hidalgo, Andres, Etheridge, SL, Duchene, J., Bianchini, M, Hub, E., Antal Rot, Thiriot, A., Thiriot, A, Igor Novitzky-Basso, Maria Casanova-Acebes, Artinger, K, Thomas Rülicke, Caamaño, Jorge; id_orcid, Moss, P., Jorge Caamaño, Hidalgo, A, von Andrian-Werburg, Ulrich, Eller, K, Artinger, Katharina, Moss, P, Bianchini, M., Mariaelvy Bianchini, Andres Hidalgo, Weber, C., Katharina Artinger, Casanova-Acebes, M, Novitzky-Basso, I., Rulicke, Thomas, Rulicke, T, Etheridge, S Leah, Megens, Remco T A, Etheridge, S. Leah, Caamano, Jorge, Novitzky-Basso, I, Katrin Nitz, Eller, K., Ruelicke, T., Hub, Elin, Von Andrian, Ulrich H, Kathrin Eller, Paul Moss, Nitz, Katrin, Nitz, K, Novitzky-Basso, Igor, Elin Hub, Christian Weber   +77 more
core   +1 more source

Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization

International Journal of Molecular Sciences, 2018
Metastasis still represents the primary cause of cancer morbidity and mortality worldwide. Chemokine signalling contributes to the overall process of cancer growth and metastasis, and their expression in both primary tumors and metastatic lesions ...
Elisabetta Marcuzzi, R. Angioni, B. Molon, B. Calì   +3 more
semanticscholar   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

The uterine-chemokine-brain axis: menstrual cycle-associated symptoms (MCAS) are in part mediated by CCL2, CCL5, CCL11, CXCL8 and CXCL10

, 2023
The uterine-chemokine-brain axis: menstrual cycle-associated symptoms (MCAS) are in part mediated by CCL2, CCL5, CCL11, CXCL8 and ...
C Roomruangwong (13330680), A F Carvalho (13330368), Michael Maes (13055841), S Sirivichayakul (13330596)   +3 more
core  

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Acupuncture Relieves Cervical Spondylosis Radiculopathy by Regulating Spinal Microglia Activation Through MAPK Signaling Pathway in Rats

Journal of Pain Research, 2023
Tianyu Shi,* Yitian Liu,* Bo Ji, Jiajia Wang, Yunpeng Ge, Yang Fang, Yana Xie, Hongli Xiao, Le Wu, Yifei Wang School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, People’s Republic of China*These ...
Shi T, Liu Y, Ji B, Wang J, Ge Y, Fang Y, Xie Y, Xiao H, Wu L, Wang Y   +9 more
doaj  

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3) [PDF]

The atypical chemokine receptor 3 (ACKR3) is a receptor that induces cancer progression and metastasis in multiple cell types. Therefore, new chemical tools are required to study the role of ACKR3 in cancer and other diseases.
Leurs, Rob, Kellam, Barrie, Kilpatrick, Laura E., Hill, Stephen J., Dekkers, Sebastian, Karsai, Noemi, Canals, Meritxell, Caspar, Birgit, Arimont-Segura, Marta, Stocks, Michael J., Briddon, Stephen J., de Graaf, Chris, Comez, Dehan   +12 more
core   +1 more source