Results 161 to 170 of about 498,931 (351)

Atypical Chemokine Receptors in Cardiovascular Disease

, 2019
Inflammation has been well recognized as one of the main drivers of atherosclerosis development and therefore cardiovascular diseases (CVDs). It has been shown that several chemokines, small 8 to 12 kDa cytokines with chemotactic properties, play a ...
Weber, Christian, Duchene, Johan, Döring, Yvonne, Gencer, Selin, Aslani, Maria, van der Vorst, Emiel P. C.   +5 more
core   +1 more source

Functional role of the CXCR4 chemokine receptor in thyroid cancer [PDF]

, 2009
Thyroid cancer is the most common endocrine malignancy and its incidence is increasing worldwide. We previously found that normal rat thyroid cells, transduced with papillary thyroid cancer (PTC)-related oncogenes, display an inflammatory signature, that
Avilla, Elvira
core   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

The uterine-chemokine-brain axis: menstrual cycle-associated symptoms (MCAS) are in part mediated by CCL2, CCL5, CCL11, CXCL8 and CXCL10

, 2020
The uterine-chemokine-brain axis: menstrual cycle-associated symptoms (MCAS) are in part mediated by CCL2, CCL5, CCL11, CXCL8 and ...
C Roomruangwong (13330680), AF Carvalho (13973112), S Sirivichayakul (13330596), M Maes (13320648)   +3 more
core  

Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury

, 2012
Rationale: Acute lung injury (ALI) causes high mortality, but its molecular mechanisms and therapeutic options remain ill-defined. Gram-negative bacterial infections are the main cause of ALI, leading to lung neutrophil infiltration, permeability ...
Malgorzata Wygrecka, Markart, Philipp, Sarawuth Wantha, Hackeng, Tilman M.; id_orcid, Philipp von Hundelshausen, Morgelin, Matthias, Klaus T. Preissner, Grommes, Jochen, Matthias Mörgelin, Tilman M. Hackeng, Wolfgang M. Kuebler, Weber, Christian, Jacobs, Michael, Söhnlein, Oliver, Philipp Markart, Koenen, Rory R., Koenen, Rory R.; id_orcid, Drechsler, Maik, Jochen Grommes, Preissner, Klaus T., Oliver Soehnlein, Hackeng, Tilman M., Koenen, Robert Ryan, Soehnlein, Oliver, Jean-Eric Alard, Rory R. Koenen, Kuebler, Wolfgang M., von Hundelshausen, Philipp, Wygrecka, Malgorzata, Michael Jacobs, Alard, Jean-Eric, Wantha, Sarawuth, Maik Drechsler, Christian Weber   +33 more
core   +1 more source

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

Nature, 1996
T. Dragic, V. Litwin, G. Allaway, S. R. Martin, Yaoxing Huang, K. Nagashima, Charmagne S. Cayanan, P. Maddon, R. Koup, John P. Moore, W. Paxton   +10 more
semanticscholar   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies

Acta Psychiatrica Scandinavica, 2017
C. Köhler, T. Freitas, M. Maes, N. Q. de Andrade, C. Liu, Brisa Fernandes, B. Stubbs, M. Solmi, N. Veronese, N. Herrmann, C. Raison, B. J. Miller, K. Lanctôt, A. Carvalho   +13 more
semanticscholar   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source