Results 181 to 190 of about 336,238 (316)

The role of circulating cytokines in eosinophilic esophagitis: A Mendelian randomization and gene expression analysis study. [PDF]

Medicine (Baltimore)
Jiang L, Xue T, Zheng L, Zhang X, Qu X, Zhang Q.   +5 more
europepmc   +1 more source

Chemokines / Chemokine Receptors [PDF]

Mucosal Immunology, 2009
openaire   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

The emerging role of chemokines and chemokine receptors in the biological and clinical behaviour of pituitary neuroendocrine tumours: An exploratory transcriptomic study. [PDF]

J Neuroendocrinol
Silva AL, Barry S, Hipólito A, de Griné Severino M, Joaquim R, Hall C, Oliveira T, López-Presa D, Borrecho G, Tortosa F, Nobre E, Faria CC, Korbonits M, Marques P.   +13 more
europepmc   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Case Reports: Chemokine and Cytokine Profiling in Patients with Herpetic Uveitis

Nam V Nguyen,1,2,* Susanne L Linderman,3,* Tolulope Fashina,1,* Max Devine,1,2 Christopher D Conrady,1,4 Jessica G Shantha,5,6 Rafi Ahmed,3,* Steven Yeh1,6,* 1Department of Ophthalmology, University of Nebraska Medical Center, Omaha ...
Conrady CD, Linderman SL, Devine M, Shantha JG, Fashina T, Nguyen NV, Yeh S, Ahmed R   +7 more
core  

Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung. [PDF]

J Leukoc Biol
Mathie H, Medina-Ruiz L, Schuette F, Halawa H, Pocalun Z, Pitmon E, Cole J, Pingen M, Graham GJ.   +8 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Pharmacological modulation of CXCL12/CXCR4/ACKR3 for brain disorders - an overview. [PDF]

Cell Commun Signal
Kuppens A, Rogister B, Neirinckx V.
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source