Results 301 to 310 of about 501,169 (342)

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Structural Basis of Chemokine CXCL8 Monomer and Dimer Binding to Chondroitin Sulfate: Insights into Specificity and Plasticity. [PDF]

Biomolecules
Mahler BP, Nagarajan B, Sankaranarayanan NV, Joseph PRB, Desai UR, Rajarathnam K.   +5 more
europepmc   +1 more source

Lesional skin chemokine CTACK/CCL27 expression in mycosis fungoides and disease control by IFN-alpha and PUVA therapy.

, 2009
Gaia Goteri, Serena Rupoli, Anna Campanati, Antonello Costagliola, Simona Sabato, Daniela Stramazzotti, Paola Picardi, Lucia Canafoglia, Stefano Pulini, Giulia Ganzetti, Anna Maria Offidani, Pietro Leoni   +11 more
openalex   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Thykamine™: A New Player in the Field of Anti-Inflammatory Drugs. [PDF]

Biomedicines
Lynde C, Flamand L, McCarty V, Sampalis J.   +3 more
europepmc   +1 more source

Inhibition of constitutive activity of the atypical chemokine receptor 3 by the small-molecule inverse agonist VUF16840. [PDF]

Mol Pharmacol
Bosma R, Nesheva D, Rijnsburger M, Riemens R, Adamska JM, Meyrath M, Mobach S, Buzink CM, van der Pol S, de Esch IJP, Szpakowska M, Wijtmans M, Chevigne A, Vischer HF, Leurs R.   +14 more
europepmc   +1 more source

Profiling an Enhanced IL-6 Expression Distinguishes Host Susceptibility to Primary and Secondary Infections of the Dengue Virus in an Ex Vivo Whole-Blood Coculture Model. [PDF]

J Trop Med
Nanda JD, Jhan MK, Satria RD, Wang YT, Ho TS, Sufriyana H, Su EC, Lin CF, Das B.   +8 more
europepmc   +1 more source

CXCR3/CXCL10 Axis-Mediated T Cell Infiltration in the Lungs of Patients With HTLV-1-Associated Diseases: Implications for Subclinical Pulmonary Involvement. [PDF]

J Med Virol
Tsuchimoto K, Mori A, Tanaka M, Arishima S, Kodama D, Dozono M, Nozuma S, Takashima H, Kubota R.   +8 more
europepmc   +1 more source

CC/CXC chemokine risk signature at single-cell resolution: a machine learning model for precision stratification in cervical cancer. [PDF]

Transl Cancer Res
Xu B, Shi X, Liu Y, Xu L, Zhou Q.
europepmc   +1 more source