Results 101 to 110 of about 86,546 (282)

Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway

Experimental and Molecular Medicine
Lower back pain (LBP), which is a primary cause of disability, is largely attributed to intervertebral disc degeneration (IDD). Macrophages (MΦs) in degenerated intervertebral discs (IVDs) form a chronic inflammatory microenvironment, but how MΦs are ...
Shuo Tian, Xuanzuo Chen, Wei Wu, Hui Lin, Xiangcheng Qing, Sheng Liu, BaiChuan Wang, Yan Xiao, Zengwu Shao, Yizhong Peng   +9 more
doaj   +1 more source

Impact of bindarit, a CCL2 chemokine synthesis inhibitor, on macrophage-based biofouling and continuous glucose monitoring in vivo

Biosensors and Bioelectronics: X
Continuous glucose monitoring (CGM) using implantable glucose sensors is a critical tool in the management of diabetes. Unfortunately, current commercial glucose sensors have limited performance and lifespans in vivo, considered to be due to sensor ...
Roshanak Sharafieh, Yi Qiao, Izabela Godlewski, Caroline Czajkowski, Rong Wu, Geneva R. Hargis, Don Kreutzer, Ulrike Klueh   +7 more
doaj   +1 more source

Chemokine mediated monocyte trafficking into the retina: role of inflammation in alteration of the blood-retinal barrier in diabetic retinopathy. [PDF]

PLoS ONE, 2014
Inflammation in the diabetic retina is mediated by leukocyte adhesion to the retinal vasculature and alteration of the blood-retinal barrier (BRB). We investigated the role of chemokines in the alteration of the BRB in diabetes.
Sampathkumar Rangasamy, Paul G McGuire, Carolina Franco Nitta, Finny Monickaraj, Sreenivasa R Oruganti, Arup Das   +5 more
doaj   +1 more source

Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]

, 2009
Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Berberich, Nina, Bihari, Peter, Khandoga, Alexander G., Krombach, Fritz, Lerchenberger, Max, Rehberg, Markus, Reichel, Christoph A., Zahler, Stefan   +7 more
core   +1 more source

The CC Chemokine Ligand 2 (CCL2) Mediates Fibroblast Survival through IL-6 [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2007
Apoptosis of lung structural cells is crucial in the process of normal tissue repair. Insufficient apoptosis of lung fibroblasts may contribute to the development of fibrosis. Since the CC chemokine ligand 2 (CCL2) is associated with fibrotic disease and the cytokine IL-6 blocks apoptosis in many cell types, we hypothesized that CCL2 may contribute to ...
Xiangde, Liu, Anuk M, Das, Jonathan, Seideman, Don, Griswold, Chantal N, Afuh, Tetsu, Kobayashi, Shinji, Abe, Qiuhong, Fang, Mitsu, Hashimoto, Huijung, Kim, Xingqi, Wang, Lei, Shen, Shin, Kawasaki, Stephen I, Rennard   +13 more
openaire   +2 more sources

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Predictive value of chemokines (CCL 2) in bronchoalveolar lavage fluid for refractory mycoplasma pneumonia in children

Italian Journal of Pediatrics, 2023
Background There are relatively few studies investigating C-C motif chemokine ligand 2 (CCL2) level in bronchoalveolar lavage fluid (BALF) in children with Mycoplasma pneumoniae pneumonia (MPP), and the relationship between CCL2 level in BALF and ...
Jiangwei Zhu, Xue Liu, Xiaowen Zhan, Mengzhu Wang, Yuling Zhang, Li Na, Shujun Li   +6 more
doaj   +1 more source

GOexpress: an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data [PDF]

, 2016
Background: Identification of gene expression profiles that differentiate experimental groups is critical for discovery and analysis of key molecular pathways and also for selection of robust diagnostic or prognostic biomarkers.
Gordon, SV, Hernández, B, MacHugh, DE, Magee, DA, McGettigan, PA, Nalpas, NC, Parnell, AC, Rue-Albrecht, K   +7 more
core   +4 more sources

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Gene expression pattern of CCL2, CCL3, and CXCL8 in patients with bipolar disorder

Journal of Research in Medical Sciences, 2019
Background: Bipolar disorder (BD) is one of the most important psychiatric disorders in the world. There is evidence suggesting the role of inflammatory mediators such as chemokines in the etiology of BD.
Mohsen Ghoryani, Farhad Faridhosseini, Ali Talaei, Reza Faridhosseini, Jalil Tavakkol-Afshari, Maliheh Dadgar Moghaddam, Parisa Azim, Zanireh Salimi, Hadi Zare Marzouni, Mojgan Mohammadi   +9 more
doaj   +1 more source