Advances in the multifunctional roles of CX3CL1 in the central nervous system [PDF]
Frontiers in Aging NeuroscienceC-X3-C motif chemokine ligand 1 (CX3CL1), a structurally unique chemokine in the central nervous system (CNS), shapes physiological and pathological processes via specific binding to its receptor, C-X3-C motif chemokine receptor 1 (CX3CR1).
Yuhui Chen +15 more
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An overview of the role of chemokine CX3CL1 (Fractalkine) and CX3C chemokine receptor 1 in systemic sclerosis [PDF]
Immunity, Inflammation and DiseaseIntroduction Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis, vascular damage, and immune dysregulation. Fractalkine or chemokine (C‐X3‐C motif) ligand 1 (CX3CL1), a chemokine and adhesion molecule, along with its ...
Fatemehsadat Pezeshkian +2 more
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The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer [PDF]
Neoplasia: An International Journal for Oncology ResearchT-cell recruiting chemokines are required for a successful immune intervention in ovarian cancer, and also for the efficacy of modern anticancer agents such as PARP inhibitors.
Stefanie Seitz +13 more
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Glycosaminoglycan binding to soluble CX3CL1 impacts monocyte migration in vitro [PDF]
Frontiers in ImmunologyIntroductionIn addition to providing shear-resistant cell-cell adhesion in its natural membrane-bound form, the soluble variant of CX3CL1 (or fractalkine) promotes strong cell migration through signaling via its unique G-protein-coupled receptor CX3CR1 ...
Maria Ennemoser +8 more
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CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration [PDF]
Journal of Neuroinflammation, 2010 The causes of age-related macular degeneration (AMD) are not well understood. Due to demographic shifts in the industrialized world a growing number of people will develop AMD in the coming decades.
Camelo Serge +6 more
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Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease [PDF]
Frontiers in Aging NeuroscienceIntroductionThe role of the chemokine CX3CL1 in the processes of aging and Alzheimer’s disease (AD) pathogenesis is well-established. This study aims to evaluate the diagnostic potential of urinary CX3CL1 levels in distinguishing between AD patients ...
Yali Xu +8 more
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CX3CL1 deficiency ameliorates acute kidney injury by inhibiting macrophage mitochondrial dysfunction and mtDNA-cGAS-STING signaling [PDF]
Cell Death DiscoveryDysregulated mitochondrial dynamics and macrophage-driven inflammation are essential contributors to the pathogenesis of acute kidney injury (AKI).
Qiming Gong +8 more
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Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor. [PDF]
PLoS Pathogens, 2011 Pathogens have evolved sophisticated mechanisms to evade detection and destruction by the host immune system. Large DNA viruses encode homologues of chemokines and their receptors, as well as chemokine-binding proteins (CKBPs) to modulate the chemokine ...
Xiaoguang Xue +8 more
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Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient. [PDF]
, 2016 BACKGROUND: Adoptive T-cell based immunotherapies constitute a promising approach to treat cancer, however, a major problem is to obtain effective and long-lasting anti-tumor responses.
Allavena, P. +4 more
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Future Journal of Pharmaceutical Sciences, 2022 Background Fractalkine (CX3CL1) is a chemokine predominantly released by neurons. As a signaling molecule, CX3CL1 facilitates talk between neurons and glia. CX3CL1 is considered as a potential target which could alleviate neuroinflammation.
Deepraj Paul, Duraiswamy Basavan
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