Results 101 to 110 of about 16,804 (217)

Camel Milk as a Functional Food: Nutritional Composition, Health‐Promoting Benefits, and Safety Considerations

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Camel milk contains low lactose, unique casein proteins, high vitamin contents, and diverse bioactive compounds that support metabolic health, immune function, organ protection, gut health, physical development, and brain function. Its benefits are mediated through antioxidant, anti‐inflammatory, insulin‐like effects, and immunomodulatory mechanisms ...
Gudisa Bereda, Subasini Uthirapathy, Javed Ahamad   +2 more
wiley   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Mutational burden of hepatoblastomas: a role for the CX3CL1/CX3CR1 chemokine signaling pathway [PDF]

, 2019
ABSTRACTBackgroundHepatoblastoma is an embryonal liver tumor supposed to arise from the impairment of hepatocyte differentiation during embryogenesis. CTNNB1 is the only recurrently mutated gene, and this relative paucity of somatic mutations poses a challenge to risk stratification and development of targeted therapies.MethodsIn this study, we ...
Marques Aguiar, Talita Ferreira, Rivas, Maria Prates, Costa, Silvia, Rodrigues, Tatiane, de Barros, Juliana Sobral, Barbosa, Anne Caroline, Maschietto, Mariana, Valieris, Renan, Fernandes, Gustavo Ribeiro, Cypriano, Monica, de Toledo, Silvia Regina Caminada, Major, Angela, Tojal, Israel, de Pinho Apezzato, Maria Lúcia, Carraro, Dirce Maria, Rosenberg, Carla, da Costa, Cecilia Maria Lima, da Cunha, Isabela Werneck, Sarabia, Stephen Frederick, Terrada, Dolores-López, Krepischi, Ana Cristina Victorino   +20 more
openaire   +1 more source

Cx3cr1-deficient microglia exhibit a premature aging transcriptome. [PDF]

, 2019
CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. However, the molecular mechanisms underlying Cx3cr1 signaling are not well understood.
Allaire, Norm, Burkly, Linda, Challa, Ravi, Cotleur, Anne C, Cullen, Patrick, Glass, Christopher K, Gosselin, David, Gyoneva, Stefka, Hosur, Raghavendra, Miao, Kelly, Ouyang, Zhengyu, Peterson, Michael, Ransohoff, Richard M, Reynolds, Taylor L, Roberts, Chris, Zhang, Baohong   +15 more
core  

Cutting Edge : Failure of Antigen-Specific CD4+ T Cell Recruitment to the Kidney during Systemic Candidiasis [PDF]

, 2014
Copyright © 2014 The Authors. Acknowledgments We thank E. Bolton and H. Bagavant for reagents and advice. We also acknowledge the staff of the Medical Research Facility at the University of Aberdeen for care of the animals used in this study.
Brown, Gordon D, Drummond, Rebecca A, Kaplan, Daniel H, Reid, Delyth M, Wallace, Carol, Way, Sing Sing   +5 more
core   +2 more sources

Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments

Oncology Reports, 2015
Several chemokines/chemokine receptors such as CXCL12, CCL3, CXCR4 and CCR1 attract multiple myelomas to specific microenvironments. In the present study, we investigated whether the CX3CL1/CX3CR1 axis is involved in the interaction of the multiple myeloma cells with their microenvironment.
Akinori, Wada, Aya, Ito, Hirofumi, Iitsuka, Koichi, Tsuneyama, Takayoshi, Miyazono, Jun, Murakami, Naotoshi, Shibahara, Hiroaki, Sakurai, Ikuo, Saiki, Takashi, Nakayama, Osamu, Yoshie, Keiichi, Koizumi, Toshiro, Sugiyama   +12 more
openaire   +3 more sources

Fractalkine Modulates Microglia Metabolism in Brain Ischemia

Frontiers in Cellular Neuroscience, 2019
In the CNS, the chemokine CX3CL1 (fractalkine) is expressed on neurons while its specific receptor CX3CR1 is expressed on microglia and macrophages.
Clotilde Lauro, Giuseppina Chece, Lucia Monaco, Fabrizio Antonangeli, Giovanna Peruzzi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Cristina Limatola, Cristina Limatola   +9 more
doaj   +1 more source

Effects of CX3CL1 inhibition on murine bleomycin-induced interstitial pneumonia

European Journal of Inflammation, 2020
Background: Treatment for interstitial pneumonia (IP) associated with collagen diseases has not been established. There is a need to elucidate the pathogenesis of IP and develop a novel therapy.
Soichi Yamada, Shion Miyoshi, Junko Nishio, Satoshi Mizutani, Zento Yamada, Natsuko Kusunoki, Hiroshi Sato, Yoshikazu Kuboi, Kana Hoshino-Negishi, Naoto Ishii, Toshio Imai, Tetsuo Mikami, Hiroyasu Nakano, Shinichi Kawai, Toshihiro Nanki   +14 more
doaj   +1 more source

Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis [PDF]

, 2012
BACKGROUND: Multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) are debilitating neuroinflammatory diseases mediated by lymphocyte entry into the central nervous system (CNS).
Deeqa A Mahamed, Jeffrey H Mills, Leah M Alabanza, Margaret S Bynoe   +3 more
core   +1 more source

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source