Results 181 to 190 of about 16,804 (217)

Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1

Cellular and Molecular Life Sciences, 2010
The surface-expressed transmembrane CX3C chemokine ligand 1 (CX3CL1/fractalkine) induces firm adhesion of leukocytes expressing its receptor CX3CR1. After shedding by the disintegrins and metalloproteinases (ADAM) 10 and 17, CX3CL1 also acts as soluble leukocyte chemoattractant.
Nicole, Schwarz, Jessica, Pruessmeyer, Franz M, Hess, Daniela, Dreymueller, Elena, Pantaler, Anne, Koelsch, Reinhard, Windoffer, Matthias, Voss, Alisina, Sarabi, Christian, Weber, Antonio S, Sechi, Stefan, Uhlig, Andreas, Ludwig   +12 more
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Glial cross-talk by transmembrane chemokines CX3CL1 and CXCL16

Journal of Neuroimmunology, 2008
The transmembrane chemokines CX3CL1 and CXCL16 mediate chemotaxis and cell to cell adhesion by interaction with their receptors CXCR6 and CX3CR1, respectively. We here summarize reports on the expression, regulation and proteolytic processing of transmembrane chemokines by glial cells, their activity on glial cells/glial precursor cells and their role ...
Andreas, Ludwig, Rolf, Mentlein
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The chemokine CX3CL1 regulates NK cell activity in vivo

Cellular Immunology, 2003
In vitro, chemokines can both activate and induce migration of NK cells. However, little is known about how chemokines influence NK cell activity in vivo. We studied the role of CX(3)CL1 and its receptor, CX(3)CR1, in modulating NK cell activity in an established in vivo model of tumour cell clearance.
Lisa A, Robinson, Chandra, Nataraj, Dennis W, Thomas, Josette M, Cosby, Robert, Griffiths, Victoria L, Bautch, Dhavalkumar D, Patel, Thomas M, Coffman   +7 more
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Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity

Journal of Neuroimmunology, 2005
Excitotoxicity is a cell death caused by excessive exposure to glutamate (Glu), contributing to neuronal degeneration in many acute and chronic CNS diseases. We explored the role of fractalkine/CX3CL1 on survival of hippocampal neurons exposed to excitotoxic doses of Glu.
LIMATOLA, Cristina, LAURO, CLOTILDE, CATALANO, Myriam, CIOTTI MT, BERTOLLINI, Cristina, DI ANGELANTONIO, SILVIA, RAGOZZINO, Davide Antonio, EUSEBI, Fabrizio   +7 more
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Chemokine CX3CL1 and its receptor CX3CR1 are associated with human atherosclerotic lesion volnerability

Thrombosis Research, 2015
CX3CL1 and its receptor CX3CR1 have been emphasized in atherosclerosis recently. In this study we investigated the role of the chemokines CX3CL1 and their receptor CX3CR1 in atherogenesis and identified whether the genetic variations in CX3CL1 and CX3CR1 impacted the atherosclerosis process in coronary artery disease (CAD) or not.CX3CL1/CX3CR1 ...
Xiaolin, Zhang, Xueyao, Feng, Wenzhi, Cai, Tengfei, Liu, Zhenyang, Liang, Ying, Sun, Chenghui, Yan, Yaling, Han   +7 more
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Assessment of the Recycling of the Membrane-Bound Chemokine, CX3CL1

2011
Fractalkine (CX(3)CL1) is a membrane-anchored chemokine whose N-terminus contains a unique CX(3)C motif that is cleaved and released. The membrane-bound form functions as an adhesion molecule and the secreted form as a chemotactic factor. Like other chemokines, CX(3)CL1 is regulated at the levels of transcription and translation. Recent evidence points
Sajedabanu Patel, Ilya Mukovozov, Lisa A. Robinson   +2 more
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Mo1696 CX3CL1-CX3CR1 in Acute Colitis: Evidence for Chemokine-Mediated Leukocyte Recruitment

Gastroenterology, 2015
The gastrointestinal microbial communities of C57BL/6 mice between Taconic Farms (Tac) and Jackson Laboratory (Jax) are highly variable; most notably, only the Tac mice are colonized with segmented filamentous bacteria (SFB), a potent inducer of proinflammatory TH17 cells.
Felix Becker, Christina Holthoff, Christoph Anthoni, Jonathan S. Alexander, Felicity N. Gavins, Norbert Senninger, Thorsten Vowinkel   +6 more
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Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine Systems in Hypoxic Pulmonary Hypertension

American Journal of Respiratory Cell and Molecular Biology, 2017
Monocytes/macrophages are major effectors of lung inflammation associated with various forms of pulmonary hypertension (PH). Interactions between the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine systems that guide phagocyte infiltration are incompletely understood. Our objective was to explore the individual and combined actions of CCL2/CCR2 and CX3CL1/CX3CR1
Rodero, Mathieu P, Amsellem, Valerie, Abid, Shariq, Poupel, Lucie, Parpaleix, Aurélien, Rodéro, Mathieu, Gary-Bobo, Guillaume, Latiri, Mehdi, Dubois-Randé, Jean-Luc, Lipskaia, Larissa, Combadiere, Christophe   +10 more
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Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by α- and γ-secretases

Biochemical and Biophysical Research Communications, 2007
The chemokines CX3CL1/Fractalkine and CXCL16 are expressed as transmembrane molecules and can mediate cell-cell-adhesion. By proteolytic processing, CX3CL1 and CXCL16 are released from the cell surface by proteolytic shedding resulting in the generation of soluble chemoattractants.
A, Schulte, B, Schulz, M G, Andrzejewski, C, Hundhausen, S, Mletzko, J, Achilles, K, Reiss, K, Paliga, C, Weber, S Rose, John, A, Ludwig   +10 more
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Chemokine–Chemokine Receptor CCL2–CCR2 and CX3CL1–CX3CR1 Axis May Play a Role in the Aggravated Inflammation in Primary Biliary Cirrhosis

Digestive Diseases and Sciences, 2013
Senescent cells can alter local tissue environments by secretion of various senescence-associated secretory phenotypes (SASP), such as cytokines and chemokines. Given senescent biliary epithelial cells (BECs) in damaged small bile ducts in primary biliary cirrhosis (PBC) show increased expression of chemokines CCL2 and CX3CL1 as SASP, we further ...
Motoko, Sasaki, Masami, Miyakoshi, Yasunori, Sato, Yasuni, Nakanuma   +3 more
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