Results 11 to 20 of about 16,804 (217)

Chemokine CX3CL1 has potential anti-fibrosis effect in mouse liver fibrosis [PDF]

Jichu yixue yu linchuang, 2023
Objective To explore the effect and mechanism of chemokine CX3CL1 on mouse liver fibrosis model. Methods C57BL/6 mice were randomly divided into CCl-4 model group and normal control group with 8 animals in each group. The model group was injected with 10%
CHENG Qi, LI Ning, YU Kangkang, SHI Guangfeng
doaj   +2 more sources

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus

Frontiers in Cell and Developmental Biology, 2023
Diabetes-related pathophysiological alterations and various female reproductive difficulties were common in pregnant women with gestational diabetes mellitus (GDM), who had 21.1 million live births.
Amin Ullah, Jing Zhao, Rajeev K. Singla, Rajeev K. Singla, Bairong Shen   +4 more
doaj   +3 more sources

Pathological Role of Fractalkine/CX3CL1 in Rheumatic Diseases: A unique chemokine with multiple functions [PDF]

Frontiers in Immunology, 2012
Understanding rheumatic diseases from the perspective of chemokine biology has shaped and will continue to shape our approach for targeted drug design.
Brian A. Jones, Alisa Erika Koch, Salahuddin eAhmed   +2 more
doaj   +3 more sources

Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy. [PDF]

Int J Mol Sci
Diabetes mellitus (DM) is the most common metabolic disease in humans, and its prevalence is increasing worldwide in parallel with the obesity pandemic. A lack of insulin or insulin resistance, and consequently hyperglycemia, leads to many systemic disorders, among which diabetic encephalopathy (DE) is a long-term complication of the central nervous ...
Wątroba M, Grabowska AD, Szukiewicz D.
europepmc   +3 more sources

The chemokine CX3CL1/fractalkine regulates immunopathogenesis during fungal-associated allergic airway inflammation.

Am J Physiol Lung Cell Mol Physiol, 2021
Individuals that present with difficult-to-control asthma and sensitivity to one or more fungal species are categorized as a subset of severe asthma patients belonging to a group herein referred to as severe asthma with fungal sensitization (SAFS). We have previously reported the identification of numerous cytokines and chemokines that were elevated ...
Godwin MS, Jones M, Blackburn JP, Yu Z, Matalon S, Hastie AT, Meyers DA, Steele C.   +7 more
europepmc   +4 more sources

Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytes to chemokine CX3CL1. [PDF]

Sci Rep, 2016
AbstractMalaria caused by Plasmodium falciparum is associated with cytoadherence of infected red blood cells (iRBC) to endothelial cells. Numerous host molecules have been involved in cytoadherence, including the adhesive chemokine CX3CL1. Most of the identified parasite ligands are from the multigenic and hypervariable Plasmodium falciparum ...
Hermand P, Cicéron L, Pionneau C, Vaquero C, Combadière C, Deterre P.   +5 more
europepmc   +3 more sources

Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory. [PDF]

Geroscience, 2022
Cognitive function progressively declines with advancing age. The aging process can be promoted by obesity and attenuated by exercise. Both conditions affect levels of the chemokine CX3CL1 in peripheral tissues; however, its role in cognitive aging is unknown.
Takei Y, Amagase Y, Iida K, Sagawa T, Goto A, Kambayashi R, Izumi-Nakaseko H, Matsumoto A, Kawai S, Sugiyama A, Takada T, Hirasawa A.   +11 more
europepmc   +3 more sources

Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice

Pharmaceuticals, 2021
CX3C Motif Chemokine Ligand 1 (CX3CL1; fractalkine) has been implicated in the pathogenesis of rheumatoid arthritis (RA) and its inhibition was found to attenuate arthritis in mice as well as in a clinical trial. Therefore, we investigated the effects of
Satoshi Mizutani, Junko Nishio, Kanoh Kondo, Kaori Motomura, Zento Yamada, Shotaro Masuoka, Soichi Yamada, Sei Muraoka, Naoto Ishii, Yoshikazu Kuboi, Sho Sendo, Tetuo Mikami, Toshio Imai, Toshihiro Nanki   +13 more
doaj   +1 more source

Expression of Chemokine XCL2 and CX3CL1 in Lung Cancer [PDF]

Medical Science Monitor, 2016
BACKGROUND Chemokines are a family of small proteins secreted by cells with chemotactic activity, and they play important roles in cell adhesion. However, the expression of chemokine XCL2 and CX3CL1 in lung cancers in different pathological stages remains unclear.
Zhou, Bing, Xu, Heyun, Ni, Kewei, Ni, Xuming, Shen, Jian   +4 more
openaire   +2 more sources

Chemokines and atherosclerosis: focus on the CX3CL1/CX3CR1 pathway [PDF]

Acta Pharmacologica Sinica, 2013
Atherosclerosis is currently considered an inflammatory disease. Much attention has been focused on the potential role of inflammatory mediators as prognostic/diagnostic markers or therapeutic targets of atherosclerotic cardiovascular disease. CX3CL1 (or fractalkine) is a structurally and functionally unique chemokine with a well documented role in ...
Stavros, Apostolakis, Demetrios, Spandidos   +1 more
openaire   +2 more sources