Biochemistry and Biophysics Reports, 2021 Cytokines and chemokines trigger complex intracellular signaling through specific receptors to mediate immune cell recruitment and activation at the sites of infection.
Abha Sahni +2 more
doaj +1 more source
Recycling of the Membrane-anchored Chemokine, CX3CL1 [PDF]
Journal of Biological Chemistry, 2005 CX(3)CL1 (fractalkine) plays an important role in inflammation by acting as both chemoattractant and as an adhesion molecule. As for other chemokines, expression of CX(3)CL1 is known to be regulated at the level of transcription and translation. The unique transmembrane structure of CX(3)CL1 raises the possibility of additional functional regulation by
Guang-Ying, Liu +6 more
openaire +2 more sources
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]
, 2006 We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina +8 more
core +1 more source
CX3CL1 as potential immunotherapeutic tool for bone metastases in lung cancer: A preclinical study
Advances in Cancer Biology - Metastasis, 2022 The chemokine CX3CL1 emerges as a double-edged sword in the pathophysiology of cancer. We investigated whether CX3CL1 would act as an impediment or as a support to the development of non-small cell lung cancer skeletal metastases.We set up an in vivo ...
Charlotte Cohen +12 more
doaj +1 more source
CX3CR1 Polymorphisms are associated with atopy but not asthma in German children [PDF]
, 2007 Chemokines and their receptors are involved in many aspects of immunity. Chemokine CX3CL1, acting via its receptor CX3CR1, regulates monocyte migration and macrophage differentiation as well as T cell-dependent inflammation.
Christian Vogelberg +20 more
core +2 more sources
Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
iScience, 2023 Summary: The human cytomegalovirus (HCMV)-encoded chemokine receptor US28 contributes to various aspects of the viral life cycle and promotes immune evasion by scavenging chemokines from the microenvironment of HCMV-infected cells.
Maarten P. Bebelman +10 more
doaj +1 more source
Perivascular adipose tissue inflammation in vascular disease [PDF]
, 2017 Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core +1 more source
Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent manner. [PDF]
PLoS ONE, 2012 Tumor formation is an extensive process requiring complex interactions that involve both tumor cell-intrinsic pathways and soluble mediators within the microenvironment.
Johanna R Reed +5 more
doaj +1 more source
Inhibition of chemokine CX3CL1 in spinal cord mediates the electroacupuncture-induced suppression of inflammatory pain. [PDF]
J Pain Res, 2019 Chemokine CX3CL1 and its receptor CX3CR1 in the lumbar spinal cord play crucial roles in pain processing. Electroacupuncture (EA) is recognized as an alternative therapy in pain treatment due to its efficacy and safety. However, the analgesic mechanism of EA remains unclear. The aim of this study was to investigate whether EA suppressed complete Freund'
Li Y +7 more
europepmc +5 more sources
The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area. [PDF]
, 2016 Chemokines have several physio-pathological roles in the brain. Among them, the modulation of synaptic contacts and neurotransmission recently emerged as crucial activities during brain development, in adulthood, upon neuroinflammation and ...
DI CASTRO, MARIA AMALIA +5 more
core +1 more source