Results 51 to 60 of about 369,183 (362)

Atypical chemokine receptors

Experimental Cell Research, 2011
Atypical chemokine receptors (ACRs) are cell surface receptors with seven transmembrane domains structurally homologous to chemokine G-protein coupled receptors (GPCRs). However, upon ligation by cognate chemokines, ACRs fail to induce classical signaling and downstream cellular responses characteristic for GPCRs.
Antal Rot, Maria H. Ulvmar, Elin Hub
openaire   +2 more sources

Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. [PDF]

, 2013
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses.
A Kaur, A Llano, A Yates, AN Phillips, Andrea Hegedus, Andrew Worth, B Asquith, Catherine de Lara, D Berhanu, Daniel C. Douek, DC Douek, DC Douek, DC Macallan, DC Macallan, DC Macallan, DC Macallan, DD Ho, Derek Macallan, DL Wallace, EJ Heeregrave, HC Lane, I den Braber, J Embretson, JM Brenchley, JM McCune, JV Giorgi, K Ladell, Karoliina Laamanen, L Cicin-Sain, LJ Picker, M Catalfamo, M Hellerstein, M Koot, MD Hazenberg, MK Hellerstein, MP Davenport, N Brieu, N Vrisekoop, Peter Beverley, R Busch, R Shankarappa, RJ De Boer, RJ De Boer, RM Ribeiro, RM Ribeiro, RS Veazey, SA Handley, TW Chun, V Sanchez, Yan Zhang   +49 more
core   +9 more sources

The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets

Journal of Immunology Research, 2014
Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine ...
M. Isabel Palacios-Arreola, Karen E. Nava-Castro, Julieta I. Castro, Eduardo García-Zepeda, Julio C. Carrero, Jorge Morales-Montor   +5 more
doaj   +1 more source

Molecular insights into kinase mediated signaling pathways of chemokines and their cognate G protein coupled receptors

Frontiers in Bioscience-Landmark, 2020
Chemokines are small regulatory proteins that play a crucial role in the coordinated migration of cell populations to the site of infection/inflammation by binding to their cognate receptors.
Deepak Kumar Tripathi, Krishna Mohan Poluri   +1 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Closely related, yet unique: Distinct homo- and heterodimerization patterns of G protein coupled chemokine receptors and their fine-tuning by cholesterol. [PDF]

PLoS Computational Biology, 2018
Chemokine receptors, a subclass of G protein coupled receptors (GPCRs), play essential roles in the human immune system, they are involved in cancer metastasis as well as in HIV-infection.
Stefan Gahbauer, Kristyna Pluhackova, Rainer A Böckmann   +2 more
doaj   +1 more source

Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis? [PDF]

, 2018
Indexación: Scopus.Papillary thyroid cancer (PTC) is the most prevalent endocrine neoplasia. The increased incidence of PTC in patients with thyroiditis and the frequent immune infiltrate found in PTC suggest that inflammation might be a risk factor for ...
Aggarwal, Akaike, Antonelli, Aoki, Balkwill, Balkwill, Balkwill, Ben-Baruch, Ben-Baruch, Ben-Baruch, Bentrem, Bikfalvi, Bressan, Carini, Caux, Cerutti, Chen, Chiovato, Clark, Evers, Fagin, Fallahi, Fallahi, Fallahi, Ferrannini, Fugazzola, Fulton, Giovannone, Harris, Haugen, Huang, Ichikawa, Ishikura, Keane, Keane, Khodarev, Kim, Lai, Lazebnik, Liao, Loetscher, Maggi, Mak, Mantovani, Mantovani, Marazuela, Marone, Matrisian, Matthys, McEvoy, Melillo, Melillo, Melillo, Melillo, Miccoli, Moser, Moser, Nagawa, Negri, Okayasu, Oppenheim, Pal, Pal, Pal, Paloyan, Paloyan, Peled, Peng, Pfaffl, Potlukova, Richmond, Richmond, Rizzoli, Rollins, Romagnani, Rothstein, Santoro, Serio, Serio, Shah, Shaha, Sonoo, Sorensen, Strieter, Strieter, Strieter, Sun, Taketo, Teixido, Toniolo, Tuttle, Vigneri, Ward, Ward, Ward, Welch, Wells, Wells, Wells, Wilhelm, Wu, Wynford-Thomas, Yang, Yeo, Zhang   +104 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Atypical Chemokine Receptor 1 Polymorphism can not Affect Susceptibility to Hepatitis C Virus

Balkan Medical Journal, 2017
Background: Hepatitis C virus has infected 130 to 150 million individuals globally. Atypical chemokine receptor 1 has become a focus of research because of its diverse roles in different diseases.
Shu-Ting Zhang, Ming Shi, Lin-Nan Shao, Shi-Hang Zhou, Wei-Jian Yu, Mei Chen, Nan Xiao, Ying Duan, Ying Duan, Ni Wang, Wen-Qian Song, Yue-Xin Xia, Li Zhang , Ning Qi, Ming Liu   +14 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source