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Chemokines, chemokine receptors and pain
Trends in Immunology, 2005Many patients suffer from neuropathic pain as a result of injury to the peripheral nervous system (e.g. post-herpetic neuralgia or diabetic neuropathy) or to the central nervous system (e.g. spinal cord injury or stroke). The most distinctive symptom of neuropathic pain is allodynia, whereby normally non-painful stimuli, such as light touch, become ...
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Chemokines and chemokine receptors in renal pathology
Current Opinion in Nephrology and Hypertension, 2003Chemokines are members of the largest group of chemotactic cytokines, and were the first shown to be able to engage specific subpopulations of inflammatory cells. Accordingly, our expanding knowledge in chemokine biology has enlarged our understanding of inflammatory cell interactions, lymphopoesis, specificity of cell recruitment, and a variety of ...
Charles E. Alpers, Stephan Segerer
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Chemokines and Chemokine Receptors Encoded by Cytomegaloviruses
2008CMVs carry several genes that are homologous to genes of the host organism. These include genes homologous to those encoding chemokines (CKs) and G protein-coupled receptors (GPCRs). It is generally assumed that these CMV genes were hijacked from the host genome during the long co-evolution of virus and host.
Patrick S. Beisser +3 more
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2016
Chemokines are a large family of secreted cytokines whose main function is to mediate leukocyte directional migration. Most cancers contain chemokines and express chemokine receptors as a consequence of the activity of deregulated transcription factors or tumor-suppressor genes.
Caronni N. +5 more
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Chemokines are a large family of secreted cytokines whose main function is to mediate leukocyte directional migration. Most cancers contain chemokines and express chemokine receptors as a consequence of the activity of deregulated transcription factors or tumor-suppressor genes.
Caronni N. +5 more
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Current Opinion in Rheumatology, 2001
Chemokines mediate the ingress of leukocytes, including neutrophils and monocytes, into the inflamed synovium. Among the four known chemokine families, C-X-C and C-C chemokines seem to be of outstanding importance in this process. Angiogenesis, the formation of new vessels, is also important in the pathogenesis of rheumatoid arthritis.
Szekanecz, Zoltán, Koch, Alisa E.
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Chemokines mediate the ingress of leukocytes, including neutrophils and monocytes, into the inflamed synovium. Among the four known chemokine families, C-X-C and C-C chemokines seem to be of outstanding importance in this process. Angiogenesis, the formation of new vessels, is also important in the pathogenesis of rheumatoid arthritis.
Szekanecz, Zoltán, Koch, Alisa E.
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Chemokines and chemokine receptors in leukocyte trafficking
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2002Chemokines regulate inflammation, leukocyte trafficking, and immune cell differentiation. The role of chemokines in homing of naive T lymphocytes to secondary lymphatic organs is probably the best understood of these processes, and information on chemokines in inflammation, asthma, and neurological diseases is rapidly increasing. Over the past 15 years,
Klaus Ley, Timothy S. Olson
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Recent Advances in Chemokines and Chemokine Receptors
Critical Reviews™ in Immunology, 1999Chemokines are a superfamily of small cytokine-like molecules which have been described primarily on the basis of their ability to mediate the migration of verious cell types, particularly those of lymphoid origin. The receptors for these molecules are all seven-transmembrane domain G protein-coupled receptors that have historically been excellent ...
Albert Zlotnik +2 more
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Chemokines and Chemokine Receptors in the Brain
2009Besides their well-established role of inducing cell migration in the immune system, it is now proven that chemokines and their receptors also play a role in the central nervous system (CNS). The best known central action is the ability of chemokines to act as immunoinflammatory mediators.
Ghazal Banisadr +3 more
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Chemokine/Chemokine Receptor Nomenclature
Journal of Interferon & Cytokine Research, 2002Antal Rot +18 more
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