Results 131 to 140 of about 25,830 (181)
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Current Problems in Cancer, 1994
Chemoprevention is a strategy used to block the development of cancers in human beings. This emerging field has broad potential for influencing cancer incidence rates in defined high-risk groups and the general population. In this review, we define some of the mechanisms of carcinogenesis, describe some of the genetic markers of carcinogenesis, and ...
C E, Szarka, G, Grana, P F, Engstrom
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Chemoprevention is a strategy used to block the development of cancers in human beings. This emerging field has broad potential for influencing cancer incidence rates in defined high-risk groups and the general population. In this review, we define some of the mechanisms of carcinogenesis, describe some of the genetic markers of carcinogenesis, and ...
C E, Szarka, G, Grana, P F, Engstrom
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Cancer Chemoprevention by Carotenoids [PDF]
Molecules, 2012 Carotenoids are natural fat-soluble pigments that provide bright coloration to plants and animals. Dietary intake of carotenoids is inversely associated with the risk of a variety of cancers in different tissues. Preclinical studies have shown that some carotenoids have potent antitumor effects both in vitro and in vivo, suggesting potential preventive
Takuji Tanaka +2 more
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Chemoprevention by Pyrimethamine
Immunopharmacology and Immunotoxicology, 2005The goal of the current research was to investigate the chemopreventive potency of an antimalaria drug, pyrimethamine, in in vitro conditions. The fibrosarcoma (WEHI-164) cell line was used for evaluating cytotoxicity, matrix metalloproteinase 2 (MMP-2) activity, and apoptosis. Pyrimethamine and methotrexate were used at concentrations of 0-8 microg/ml
Farshid, Saadat +2 more
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Journal of the American Academy of Dermatology, 2006
Despite efforts to promote sun protection behaviors, melanoma incidence continues to increase. The prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures.We sought to summarize the results of published research on candidate chemoprevention agents for ...
Shayla O, Francis +4 more
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Despite efforts to promote sun protection behaviors, melanoma incidence continues to increase. The prognosis of advanced melanoma remains extremely poor in spite of treatment advances, emphasizing the importance of exploring additional preventive measures.We sought to summarize the results of published research on candidate chemoprevention agents for ...
Shayla O, Francis +4 more
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Hematology/Oncology Clinics of North America, 1991
Chemoprevention is a relatively new area of clinical cancer research. In this article we have presented a general overview of the concepts as well as the status of ongoing clinical trials using the most promising agents in selected populations. The reader is referred to recent excellent reviews presenting more detailed discussions of the various topics
H S, Garewal, F L, Meyskens
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Chemoprevention is a relatively new area of clinical cancer research. In this article we have presented a general overview of the concepts as well as the status of ongoing clinical trials using the most promising agents in selected populations. The reader is referred to recent excellent reviews presenting more detailed discussions of the various topics
H S, Garewal, F L, Meyskens
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Chemoprevention by isothiocyanates
Journal of Cellular Biochemistry, 1995Naturally occurring and synthetic isothiocyanates are among the most effective chemopreventive agents known. A wide variety of isothiocyanates prevents cancer in the rat lung, mammary gland, esophagus, liver, small intestine, colon, and bladder. Mechanistic studies have shown that this chemopreventive activity is due to favorable modification of phase ...
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Cancer, 1993
Encouraging results from several recent trials have increased interest in the potential of chemoprevention in reducing the incidence of cancer. Treatment with 13-cis-retinoic acid has reversed oral leukoplakia, a premalignant lesion, and prevented the development of second primary carcinomas of the head and neck.
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Encouraging results from several recent trials have increased interest in the potential of chemoprevention in reducing the incidence of cancer. Treatment with 13-cis-retinoic acid has reversed oral leukoplakia, a premalignant lesion, and prevented the development of second primary carcinomas of the head and neck.
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Current Opinion in Gastroenterology, 1999
Chemoprevention is defined as nutritional or pharmaceutical interventions designed to prevent or delay cellular transformation. Over the last year, the great excitement and interest in the mechanism, epidemiology, and preclinical and clinical chemopreventive effects in the lower intestine of nonsteroidal anti-inflammatory drugs continues and is ...
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Chemoprevention is defined as nutritional or pharmaceutical interventions designed to prevent or delay cellular transformation. Over the last year, the great excitement and interest in the mechanism, epidemiology, and preclinical and clinical chemopreventive effects in the lower intestine of nonsteroidal anti-inflammatory drugs continues and is ...
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Resveratrol and chemoprevention
Cancer Letters, 2009Resveratrol is a phytoalexin, highly abundant in skins of red grapes and moderately abundant in peanuts and blueberries. Originally a constituent of oriental medicines, it has lately been rediscovered for a plethora of beneficial properties such as anti-cancer, anti-aging, antiviral, cardiovascular and neuroprotective effects, thereby making it one of ...
Shyamal K, Goswami, Dipak K, Das
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Acta Oncologica, 1998
Although there is strong epidemiological evidence to suggest the preventability of many cancers based on non-experimental studies at both ecological and individual levels, there have been few applications of that knowledge to randomized trials. The randomized trials were mainly designed to demonstrate the effect of chemoprevention on risk of cancer ...
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Although there is strong epidemiological evidence to suggest the preventability of many cancers based on non-experimental studies at both ecological and individual levels, there have been few applications of that knowledge to randomized trials. The randomized trials were mainly designed to demonstrate the effect of chemoprevention on risk of cancer ...
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