Results 41 to 50 of about 168,140 (338)

MAP17 (PDZK1IP1) and pH2AX are potential predictive biomarkers for rectal cancer treatment efficacy [PDF]

, 2018
Rectal cancer represents approximately 10% of cancers worldwide. Preoperative chemoradiotherapy increases complete pathologic response and local control, although it offers a poor advantage in survivorship and sphincter saving compared with that of ...
Carnero, Amancio, Espinosa-Sánchez, Asunción, Felipe-Abrio, Blanca, Fernández-Fernández, María Carmen, Muñoz-Galván, Sandra, Ortiz, María José, Peinado-Serrano, Javier, Rivero, María, Suarez-Martinez, Elisa   +8 more
core   +1 more source

Updated protocol of the SANO trial: a stepped-wedge cluster randomised trial comparing surgery with active surveillance after neoadjuvant chemoradiotherapy for oesophageal cancer

Trials, 2021
Background The Surgery As Needed for Oesophageal cancer (SANO) trial compares active surveillance with standard oesophagectomy for patients with a clinically complete response (cCR) to neoadjuvant chemoradiotherapy.
B. Eyck, B. J. van der Wilk, B. Noordman, B. Wijnhoven, S. Lagarde, H. Hartgrink, P. Coene, J. Dekker, M. Doukas, A. van der Gaast, J. Heisterkamp, E. Kouwenhoven, G. Nieuwenhuijzen, J. Pierie, C. Rosman, J. V. van Sandick, M. J. van der Sangen, M. Sosef, E. S. van der Zaag, M. Spaander, R. Valkema, Hester F. Lingsma, E. Steyerberg, J. V. van Lanschot   +23 more
semanticscholar   +1 more source

Metformin in Combination With Chemoradiotherapy in Locally Advanced Non-Small Cell Lung Cancer: The OCOG-ALMERA Randomized Clinical Trial.

JAMA Oncology, 2021
Importance Unresected locally advanced non-small cell lung cancer (LA-NSCLC) shows poor survival outcomes even after aggressive concurrent chemoradiotherapy.
T. Tsakiridis, G. Pond, Jim R Wright, P. Ellis, N. Ahmed, B. Abdulkarim, W. Roa, A. Robinson, A. Swaminath, G. Okawara, M. Wierzbicki, M. Valdes, M. Levine   +12 more
semanticscholar   +1 more source

Esophageal Cancer Initially Thought to be Accompanied by a Solitary Metastasis to an Intrathoracic Paraaortic Lymph Node [PDF]

, 2012
Esophageal cancers usually exhibit lymph-node metastases. Although a solitary lymph-node metastasis is occasionally found, the involvement of an intrathoracic paraaortic node is rare.
Akase, Takayoshi, Hase, Kazuo, Horio, Takuya, Maehara, Tadaaki, Ogata, Sho, Takahata, Risa, Tsujimoto, Hironori, Yaguchi, Yoshihisa   +7 more
core   +1 more source

Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.

JAMA Oncology, 2019
Importance Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant approach is warranted. Objective To evaluate the margin-negative (R0) resection rate of neoadjuvant FOLFIRINOX (fluorouracil,
Janet E. Murphy, J. Wo, D. Ryan, Jeffrey W. Clark, Wenqing Jiang, B. Yeap, L. Drapek, L. Ly, Christian V. Baglini, L. Blaszkowsky, C. Ferrone, A. Parikh, C. Weekes, R. Nipp, E. Kwak, Jill N. Allen, R. Corcoran, D. Ting, J. Faris, A. Zhu, L. Goyal, D. Berger, M. Qadan, K. Lillemoe, Nilesh P. Talele, R. Jain, T. Delaney, D. Duda, Y. Boucher, C. F. Fernandez-Del Castillo, T. Hong   +30 more
semanticscholar   +1 more source

Hypermethylation and Downregulation of UTP6 Are Associated With Stemness Properties, Chemoradiotherapy Resistance, and Prognosis in Rectal Cancer: A Co-expression Network Analysis

Frontiers in Cell and Developmental Biology, 2021
BackgroundTo identify the hub genes associated with chemoradiotherapy resistance in rectal cancer and explore the potential mechanism.MethodsWeighted gene co-expression network analysis (WGCNA) was performed to identify the gene modules correlated with ...
Yiyi Zhang, Qiao Gao, Yong Wu, Yong Peng, Jinfu Zhuang, Yuanfeng Yang, Weizhong Jiang, Xing Liu, Guoxian Guan   +8 more
doaj   +1 more source

Chemoradiotherapy in Cancer Treatment: Rationale and Clinical Applications

Anticancer Research, 2021
Chemoradiotherapy (CRT) refers to the combined administration of both chemotherapy and radiotherapy as an anticancer treatment. Over the years, CRT has become an established treatment for a diverse range of locally advanced solid tumours.
Kathrine S. Rallis, Thomas Ho Lai Yau, M. Sideris   +2 more
semanticscholar   +1 more source

Induction chemotherapy followed by neoadjuvant chemoradiotherapy and surgery in locally advanced rectal cancer: preliminary results of a phase II study [PDF]

, 2018
PURPOSE: To report preliminary results of induction chemotherapy (IC) followed by neoadjuvant chemoradiotherapy (CRT) and surgery in locally advanced rectal cancer (LARC) patients.MATERIALS AND METHODS: This is the preliminary evaluation of a phase II ...
Benevento, Ilaria, Bulzonetti, Nadia, Cortesi, Enrico, D'Ambrosio, Giancarlo, De Felice, Francesca, Iafrate, Franco, Iannitti, Marcella, Mancini, Marialaura, Marampon, Francesco, Marzo, Marco, Musio, Daniela, Tombolini, Vincenzo, Urbano, Federica   +12 more
core   +1 more source

Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial

Journal of Clinical Oncology, 2018
Purpose The efficacy of neoadjuvant chemoradiotherapy (NCRT) plus surgery for locally advanced esophageal squamous cell carcinoma (ESCC) remains controversial.
Han Yang, Hui Liu, Yu-ping Chen, Chengchu Zhu, W. Fang, Zhentao Yu, W. Mao, J. Xiang, Yongtao Han, Zhijian Chen, Haihua Yang, Jia-ming Wang, Q. Pang, Xiao Zheng, Huan-jun Yang, Tao Li, F. Lordick, X. D’Journo, R. Cerfolio, R. Korst, N. Novoa, S. Swanson, A. Brunelli, M. Ismail, H. Fernando, Xu Zhang, Qun Li, Gen-jie Wang, Baofu Chen, T. Mao, M. Kong, Xufeng Guo, Ting Lin, Mengzhong Liu, J. Fu   +34 more
semanticscholar   +1 more source

The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients [PDF]

, 2018
Background: Preoperative chemoradiotherapy (CRT) followed by surgery is the standard care for locally advanced rectal cancer, but tumour response to CRT and disease outcome are variable.
A Celeghin, A Habr-Gama, AL Appelt, Alessandro Perin, AM Mandard, Angela Buonadonna, Anita De Rossi, Antonino De Paoli, C Alix-Panabières, C Belluco, Caterina Boso, Claudio Belluco, D Beddy, D Hanahan, D Lin, D Tural, E Rampazzo, E Rampazzo, E Rampazzo, EH Blackburn, Elisa Palazzari, Enrica Rampazzo, Francesca Bergamo, G Saretzki, G Spolverato, Giovanna Spiro, I Gingras, J Buijsen, J Maláska, JA March-Villalba, JF Bosset, JM Lewis, JP Gerard, K Bujko, K Kojima, L Moureau-Zabotto, L Terrin, L Terrin, LA Torre, M Maas, M Spornraft, MB Amin, MS Roh, N Miura, N Tani, P Boscolo-Rizzo, Paola Del Bianco, R Bertorelle, R Bertorelle, R Sauer, R Siegel, RK Deblakshmi, Roberta Bertorelle, S Giunco, S Pucciarelli, S Pucciarelli, Salvatore Pucciarelli, Sara Leonardi, SB Edge, SH Lim, SM Lledó, T El-Hefnawy, Y Kang   +62 more
core   +1 more source