Results 1 to 10 of about 60,935 (266)
Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2α. [PDF]
Front Physiol, 2020 Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical and chemical parameters in the blood. These cells are also essential for O2 homeostasis. Glomus cells are prototypical peripheral O2 sensors necessary to detect hypoxemia and to elicit rapid compensatory responses (hyperventilation ...
Ortega-Sáenz P +3 more
europepmc +12 more sources
Lactate sensing mechanisms in arterial chemoreceptor cells. [PDF]
Nat Commun, 2021 AbstractClassically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative phosphorylation in mitochondria, and preferred over glucose by many tissues. Lactate is also a signaling molecule of increasing medical relevance.
Torres-Torrelo H +3 more
europepmc +12 more sources
Solitary chemoreceptor cell proliferation in adult nasal epithelium [PDF]
Journal of Neurocytology, 2005 Nasal trigeminal chemosensitivity in mice and rats is mediated in part by solitary chemoreceptor cells (SCCs) in the nasal epithelium (Finger et al., 2003). Many nasal SCCs express the G-protein alpha-gustducin as well as other elements of the bitter-taste signaling cascade including phospholipase Cbeta2, TRPM5 and T2R bitter-taste receptors.
Thomas E. Finger, Brian D. Gulbransen
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Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells. [PDF]
J Physiol, 2013 Key points Arterial chemoreceptors measure blood oxygen and are involved in the control of both breathing and the cardiovascular system. Oxygen is mostly used by cells in their mitochondria to generate energy. In this study we have investigated the effects of oxygen starvation (hypoxia) on the mitochondria of specialised oxygen sensing cells from ...
Buckler KJ, Turner PJ.
europepmc +5 more sources
Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration [PDF]
Proceedings of the National Academy of Sciences, 2003 Inhalation of irritating substances leads to activation of the trigeminal nerve, triggering protective reflexes that include apnea or sneezing. Receptors for trigeminal irritants are generally assumed to be located exclusively on free nerve endings within the nasal epithelium, requiring that trigeminal irritants diffuse through the junctional ...
Wayne L. Silver +5 more
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Ca2+ Dynamics in Chemoreceptor Cells: An Overview [PDF]
, 1993 Producción ...
Javier García-Sancho +4 more
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Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body. [PDF]
The Journal of general physiology, 1989 Ionic currents of enzymatically dispersed type I and type II cells of the carotid body have been studied using the whole cell variant of the patch-clamp technique. Type II cells only have a tiny, slowly activating outward potassium current. By contrast, in every type I chemoreceptor cell studied we found (a) sodium, (b) calcium, and (c) potassium ...
Ureña, J. +3 more
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Solitary chemoreceptor cell survival is independent of intact trigeminal innervation [PDF]
Journal of Comparative Neurology, 2008 AbstractNasal solitary chemoreceptor cells (SCCs) are a population of specialized chemosensory epithelial cells presumed to broaden trigeminal chemoreceptivity in mammals (Finger et al. [2003] Proc Natl Acad Sci USA 100:8981–8986). SCCs are innervated by peptidergic trigeminal nerve fibers (Finger et al.
Thomas E. Finger +2 more
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Potassium channel types in arterial chemoreceptor cells and their selective modulation by oxygen. [PDF]
The Journal of general physiology, 1992 Single K+ channel currents were recorded in excised membrane patches from dispersed chemoreceptor cells of the rabbit carotid body under conditions that abolish current flow through Na+ and Ca2+ channels. We have found three classes of voltage-gated K+ channels that differ in their single-channel conductance (gamma), dependence on internal Ca2+ (Ca2+i),
Ganfornina, María Dolores +1 more
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The Molecular Basis of Amino Acids Sensing
Advanced Science, EarlyView.Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang +3 more
wiley +1 more source