Results 1 to 10 of about 14,150 (254)

Lactate sensing mechanisms in arterial chemoreceptor cells [PDF]

Nature Communications, 2021
Lactate levels in blood change during hypoxia or exercise, however whether this variable is sensed to evoke adaptive responses is unknown. Here the authors show that oxygen-sensing carotid body cells stimulated by hypoxia are also activated by lactate to
Hortensia Torres-Torrelo, Patricia Ortega-Sáenz, Lin Gao, José López-Barneo   +3 more
doaj   +10 more sources

Criteria for central respiratory chemoreceptors: experimental evidence supporting current candidate cell groups [PDF]

Frontiers in Physiology, 2023
An interoceptive homeostatic system monitors levels of CO2/H+ and provides a proportionate drive to respiratory control networks that adjust lung ventilation to maintain physiologically appropriate levels of CO2 and rapidly regulate tissue acid-base ...
Elizabeth C. Gonye, Douglas A. Bayliss
doaj   +4 more sources

Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2α [PDF]

Frontiers in Physiology, 2020
Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical and chemical parameters in the blood. These cells are also essential for O2 homeostasis.
Patricia Ortega-Sáenz, Patricia Ortega-Sáenz, Patricia Ortega-Sáenz, Alejandro Moreno-Domínguez, Alejandro Moreno-Domínguez, Lin Gao, Lin Gao, Lin Gao, José López-Barneo, José López-Barneo, José López-Barneo   +10 more
doaj   +3 more sources

Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells [PDF]

Antioxidants, 2019
Carotid body (CB) chemoreceptor cells sense arterial blood PO2, generating a neurosecretory response proportional to the intensity of hypoxia. Hydrogen sulfide (H2S) is a physiological gaseous messenger that is proposed to act as an oxygen sensor in CBs,
Teresa Gallego-Martin, Jesus Prieto-Lloret, Philip I. Aaronson, Asuncion Rocher, Ana Obeso   +4 more
doaj   +2 more sources

Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution [PDF]

eLife
The opportunistic pathogen Pseudomonas aeruginosa serves as a model organism for studying multiple signal transduction pathways. The chemoreceptor cluster, a core component of the chemotaxis pathway, is assembled from hundreds of proteins.
Zhengyu Wu, Maojin Tian, Sanyuan Fu, Min Chen, Rongjing Zhang, Junhua Yuan   +5 more
doaj   +2 more sources

Genetic map of the carotid body stem cell niche with focus on the O2-sensing chemoreceptor cell lineage [PDF]

Scientific Reports
Adaptive homeostatic responses to oxygen (O2) deficiency (hypoxia) are essential for survival. The prototypical acute O2-sensing organ is the carotid body (CB), a neural crest-derived tissue with chemoreceptor glomus cells that express hypoxia-inhibited ...
Ana Santamaría-Santiago, Verónica Sobrino, Luis Luna-Ramírez, José López-Barneo, Ricardo Pardal   +4 more
doaj   +2 more sources

SOS System Induction Inhibits the Assembly of Chemoreceptor Signaling Clusters in Salmonella enterica. [PDF]

PLoS ONE, 2016
Swarming, a flagellar-driven multicellular form of motility, is associated with bacterial virulence and increased antibiotic resistance. In this work we demonstrate that activation of the SOS response reversibly inhibits swarming motility by preventing ...
Oihane Irazoki, Albert Mayola, Susana Campoy, Jordi Barbé   +3 more
doaj   +7 more sources

Carotid body physiology meets cytochrome c oxidase crystallography Commentary to Ortega-Sáenz P, López-Barneo J. Physiology of the Carotid Body: From Molecules to Disease. Annu Rev Physiol 82: 127-149, 2020. Torres-Torrelo H, Ortega-Sáenz P, Gao L, López-Barneo J. Lactate sensing mechanisms in arterial chemoreceptor cells. Nat Commun 12: 4166, 2021. [PDF]

Pflugers Arch, 2022
Acker H, Fandrey J.
europepmc   +3 more sources

Type II Cells in the Human Carotid Body Display P2X7 Receptor and Pannexin-1 Immunoreactivity [PDF]

Biomolecules
The carotid body is a peripheral chemoreceptor that consists of clusters of chemoreceptive type I cells, glia-like type II cells, afferent and efferent nerves, and sinusoidal capillaries and arterioles.
Marcos Anache, Ramón Méndez, Olivia García-Suárez, Patricia Cuendias, Graciela Martínez-Barbero, Elda Alba, Teresa Cobo, Iván Suazo, José A. Vega, José Martín-Cruces, Yolanda García-Mesa   +10 more
doaj   +2 more sources

HilD-regulated chemotaxis proteins contribute to Salmonella Typhimurium colonization in the gut [PDF]

mBio
In the enteric pathogen Salmonella Typhimurium, invasion and motility are coordinated by HilD, a master regulator that activates expression of genes encoding the type III secretion system 1 and some motility genes, including the chemotaxis gene mcpC ...
Kendal G. Cooper, Laszlo Kari, Audrey Chong, Naman Tandon, Kathleen Doran, Lidiane Gomes Da Silva, Diane C. Cockrell, Arden Baylink, Olivia Steele-Mortimer   +8 more
doaj   +2 more sources