Results 81 to 90 of about 7,523 (233)

NADPH oxidase inhibition does not interfere with low P O 2 transduction in rat and rabbit CB chemoreceptor cells

, 1999
The aim of the present work was to elucidate the role of NADPH oxidase in hypoxia sensing and transduction in the carotid body (CB) chemoreceptor cells.
C. Gonzalez, A. Obeso, A. Gómez-Niño
core   +1 more source

Paradoxical enhancement of chemoreceptor detection sensitivity by a sensory adaptation enzyme [PDF]

, 2017
Significance Escherichia coli cells track chemical gradients with high sensitivity over a wide dynamic range, using a feedback-controlled sensory adaptation system. CheR, a receptor methyltransferase, is a key component
Frederick W. Dahlquist, Dahlquist, Frederick W, Han, Xue-Sheng, Run-Zhi Lai, Parkinson, John S, John S. Parkinson, Xue-Sheng Han, Lai, Run-Zhi   +7 more
core   +1 more source

Interindividual variability in static apnoea performance is partly explained by genetic factors

Experimental Physiology, EarlyView.
Abstract A large interindividual variability exists in maximal apnoea duration and the physiological adjustments that occur during apnoea. Although a few genes have been found to be associated with some of the cardiovascular responses during apnoea, the extent to which genetic and environmental factors contribute to individual differences in apnoea ...
Anastasios Makris, Alexandros Sotiridis, Nickos Geladas, Kalliopi Gkouskou, Vassilis Klissouras, Maria D. Koskolou   +5 more
wiley   +1 more source

Challenges in the Management of Massive Carotid Body Tumor

Case Reports in Otolaryngology
The carotid body paraganglioma is a rare benign neoplasm arising from the chemoreceptor cells of the carotid bulb. The carotid body has the largest collection of paraganglia in the head and neck with 60–70% of head and neck paraganglioma. Paraganglia are
Oluwapelumi Olusoga-Peters, Moses Ayodele Akinola, John Ifeanyi Nwadiokwu, Florence Oguntade   +3 more
doaj   +1 more source

Sensory Processing and Integration at the Carotid Body Tripartite Synapse: Neurotransmitter Functions and Effects of Chronic Hypoxia

Frontiers in Physiology, 2018
Maintenance of homeostasis in the respiratory and cardiovascular systems depends on reflexes that are initiated at specialized peripheral chemoreceptors that sense changes in the chemical composition of arterial blood.
Erin M. Leonard, Shaima Salman, Colin A. Nurse   +2 more
doaj   +1 more source

Pulmonary arterial mechanoreceptors mediate sustained sympathoexcitation during high altitude hypoxia in humans

Experimental Physiology, EarlyView.
Abstract Sympathetic nervous system activation is a hallmark of high‐altitude hypoxia, yet the afferent mechanisms remain incompletely defined. We examined the relative contributions of pulmonary arterial mechanoreceptors and carotid chemoreceptors – two excitatory pathways co‐activated by hypoxia – to sustained sympathoexcitation at altitude.
Michiel T. Ewalts, Lydia L. Simpson, Jack S. Talbot, Elliott J. Jenkins, Travis D. Gibbons, Connor A. Howe, Lauren E. Maier, Emily R. Vanden Berg, Alex M. Williams, Philip N. Ainslie, Samuel J. Oliver, Craig D. Steinback, Mike Stembridge, Jonathan P. Moore   +13 more
wiley   +1 more source

Atypical chemoreceptor arrays accommodate high membrane curvature [PDF]

, 2020
The prokaryotic chemotaxis system is arguably the best-understood signaling pathway in biology. In all previously described species, chemoreceptors organize into a hexagonal (P6 symmetry) extended array.
Yang, Wen, Ortega, D.R, Ortega, Davi R., Li, Chunhao, Crane, Brian R., Maschmann, Z.A., Kurniyati, Kurni, Crane, B.R., Muok, A.R., Li, C., Kurniyati, K., Sidi Mabrouk, Adam, Briegel, Ariane, Yang, W., Briegel, A., Sidi Mabrouk, A., Muok, Alise R., Maschmann, Zachary A.   +17 more
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GPCRs Direct Germline Development and Somatic Gonad Function in Planarians.

PLoS Biology, 2016
Planarians display remarkable plasticity in maintenance of their germline, with the ability to develop or dismantle reproductive tissues in response to systemic and environmental cues. Here, we investigated the role of G protein-coupled receptors (GPCRs)
Amir Saberi, Ayana Jamal, Isabel Beets, Liliane Schoofs, Phillip A Newmark   +4 more
doaj   +1 more source

The role of acid‐base balance in cerebrovascular and ventilatory responses to CO2 during 10 h normobaric hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend During 10 h exposures to normobaric hypoxia exposure there was a selective leftward shift in ventilatory response to hyperoxic hypercapnic rebreathing, but not the cerebrovascular response. The key findings are that the resetting of the central chemoreflex to lower PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_2}}}$ during early hypoxic ...
Holly Barclay, Saptarshi Mukerji, Bengt Kayser, Jui‐Lin Fan   +3 more
wiley   +1 more source

Reduced to oxidized glutathione ratios and oxygen sensing in calf and rabbit carotid body chemoreceptor cells

, 2001
El pdf del artículo es la versión pre-print.1. The aim of this work was to test the redox hypotheses of O2 chemoreception in the carotid body (CB). They postulate that hypoxia alters the levels of reactive oxygen species (ROS) and the ratio of reduced to
G. Sanz‐Alfayate, M. T. Agapito, Agapito, Teresa, A. Obeso, Obeso, Ana, Sanz-Alfayate, Gloria, González, Constancio, C. González   +7 more
core   +1 more source