Results 161 to 170 of about 64,721 (205)

Transforming treatment paradigms: Focus on personalized medicine for high‐grade serous ovarian cancer

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer, accounting for approximately 70% of all ovarian cancer cases and contributing significantly to the high mortality rates associated with this disease.
Pawel Kordowitzki, Britta Lange, Kevin M. Elias, Marcia C. Haigis, Sylvia Mechsner, Ioana Elena Braicu, Jalid Sehouli   +6 more
wiley   +1 more source

Lnc-PHF3-3 aggravates the chemoresistance of osteosarcoma cells to doxorubicin via the miR-142-3p/HMGB1 axis. [PDF]

Transl Oncol
Zhou J, Yang M, Zhao W, Zhang H, Cao L, Li Q, Wang G.   +6 more
europepmc   +1 more source

Expert Consensus on the Clinical Application of PI3K/AKT/mTOR Inhibitors in the Treatment of Breast Cancer (2025 Edition)

Cancer Innovation, Volume 4, Issue 3, June 2025.
ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer.
The Breast Cancer Expert Committee of the National Quality Control Center for Cancer, The Expert Committee on Cancer Prevention and Treatment of the Health China Research Center, The Society of Clinical Research on Oncology Medications of the China Anti‐Cancer Association, The Society of Onco‐Pathology of the China Anti‐Cancer Association   +3 more
wiley   +1 more source

A novel approach for engineering DHCM/GelMA microgels: application in hepatocellular carcinoma cell encapsulation and chemoresistance research. [PDF]

Front Bioeng Biotechnol
Zhou D, Li X, Liu W, Zhang M, Cheng Y, Xu Z, Gao J, Wang Y.   +7 more
europepmc   +1 more source

Extracellular vesicle‐LncRNA HOTAIR modulates esophageal cancer chemoresistance and immune microenvironment via miR‐375/CDH2 pathway

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract Chemoresistance and immune evasion remain significant barriers to effective esophageal cancer (EC) treatment. This study explores the mechanistic role of extracellular vesicles (EVs) delivering LncRNA HOTAIR in modulating these processes. Using transcriptomic profiling, LncRNA HOTAIR was identified as a critical factor in EC progression.
Tayier Tuersong, Munire Shataer, Yan Chen, Gaosi Chen, Xiaoling Li, Linjie Lei, Ayiguli Younusi, Liangying Ma   +7 more
wiley   +1 more source

Insights into the DNA damage response and tumor drug resistance. [PDF]

Cancer Biol Med
Ma X, Cheng Z, Guo C.
europepmc   +1 more source

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms

International Journal of Cancer, Volume 156, Issue 11, Page 2053-2067, 1 June 2025.
Abstract The biology of cancer is characterized by an intricate interplay of cells originating not only from the tumor mass, but also its surrounding environment. Different microbial species have been suggested to be enriched in tumors and the impacts of these on tumor phenotypes is subject to intensive investigation.
Kamil Moskal, Nimisha Khurana, Luisa Siegert, Ye Seul Lee, Hans Clevers, Eran Elinav, Jens Puschhof   +6 more
wiley   +1 more source

HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer. [PDF]

Front Mol Biosci
Li X, Li X, Ren Y, Wang L, Mao Z, Gao S, Ma P, Chen J.   +7 more
europepmc   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

Periostin-mediated activation of NF-κB signaling promotes tumor progression and chemoresistance in glioblastoma. [PDF]

Sci Rep
Shang Y, Liang Y, Zhang B, Wu W, Peng Y, Wang J, Zhang M, Niu C.   +7 more
europepmc   +1 more source