Results 161 to 170 of about 149,400 (379)

Chemoresistance can limit the success of radical surgery followed by early postoperative intraperitoneal chemotherapy in gastric carcinoma [PDF]

, 2000
Francisco Javier Lacueva, Rafael Calpena, Justo Medrano, Israel Oliver   +3 more
openalex   +1 more source

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

miR-374a-5p: A New Target for Diagnosis and Drug Resistance Therapy in Gastric Cancer

Molecular Therapy: Nucleic Acids, 2019
Chemoresistance is one of the causes associated with poor prognosis in gastric cancer. MicroRNAs (miRNAs) are important regulators of chemoresistance. Exosome-mediated delivery of anti-cancer molecules and drugs have emerged as a new approach for cancer ...
Runbi Ji, Xu Zhang, Hongbing Gu, Jichun Ma, Xiangmei Wen, Jingdong Zhou, Hui Qian, Wenrong Xu, Jun Qian, Jiang Lin   +9 more
doaj  

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features ...
Antal, Corina E, Atkins, Annette R, Becerra, Carlos R, Borazanci, Erkut, Collisson, Eric A, Dann, Amanda M, DelGiorno, Kathleen E, Donahue, Timothy R, Downes, Michael, Erikson, Galina, Evans, Ronald M, Fang, Linjing, Gao, Weina, Grandgenett, Paul M, Hollingsworth, Michael A, Huang, Peiwu, Hunter, Tony, Leblanc, Mathias, Liang, Gaoyang, Lowy, Andrew M, Lytle, Nikki K, Manor, Uri, Meisenhelder, Jill, Pawson, Tony, Reya, Tannishtha, Ridinger-Saison, Maya, Santisakultarm, Thom P, Scadeng, Miriam, Shi, Yu, Sun, Huaiyu, Terenziani, Elena, Tian, Ruijun, Umetsu, Sarah E, Von Hoff, Daniel D, Wahl, Geoffrey M, Woo, Gyunghwi, Xu, Ruilian, Yuan, Xiao   +37 more
core  

Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer

Journal of experimental & clinical cancer research : CR, 2019
Emerging evidence suggests a potential relationship between gut microbiota and the host response to chemotherapeutic drugs including 5-fluorouracil (5-Fu).
S. Zhang, Yongzhi Yang, Wen-hao Weng, Bomin Guo, G. Cai, Yanlei Ma, S. Cai   +6 more
semanticscholar   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

HMGB1 promotes chemoresistance in small cell lung cancer by inducing PARP1-related nucleophagy

Journal of Advanced Research
Introduction: Small cell lung cancer (SCLC) is prone to chemoresistance, which is closely related to genome homeostasis-related processes, such as DNA damage and repair.
Weitao Shen, Qiong Lyu, Ruibin Yi, Yueqin Sun, Wei Zhang, Ting Wei, Yueming Zhang, Jian Shi, Jian Zhang   +8 more
doaj  

microRNAs in cancer chemoresistance: The sword and the shield

Non-coding RNA Research, 2021
Cancer is a multifactorial disease and one of the leading causes of mortality worldwide. Cancer cells develop multiple strategies to reduce drug sensitivity and eventually lead to chemoresistance.
Priya Mondal, Syed Musthapa Meeran
doaj  

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway. [PDF]

, 2015
Tumor recurrence remains an obstacle after liver surgery, especially in living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC).
Geng, Wei, Li, Chang-Xian, Ling, Chang-Chun, Liu, Xiao-Bing, Lo, Chung-Mau, Ma, Yuen-Yuen, Man, Kwan, Ng, Kevin TP, Qi, Xiang, Zhai, Yuan   +9 more
core   +1 more source