Results 181 to 190 of about 64,721 (205)

TAB2 Promotes Immune Escape and Chemoresistance Through NF-κB Pathway Activation in Cervical Cancer. [PDF]

J Cell Mol Med
Wu M, Zhang Y, Wang X, Zhou Y.
europepmc   +1 more source

ARF6 Promotes AML Progression via Activation of PI3K/AKT/mTOR Signaling

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Acute myeloid leukemia (AML) represents a highly aggressive hematological malignancy characterized by a poor prognosis and a pressing demand for innovative diagnostic and prognostic biomarkers. Recent studies have indicated that ADP‐ribosylation factor 6 (ARF6) is overexpressed across various cancer types; however, its specific role
Haitao Xu, Dangui Chen, Jia Lu, Long Zhong, Lihong Wang, Jian Ge   +5 more
wiley   +1 more source

Chlorogenic Acid Enhances Beta‐Lapachone‐Induced Cell Death by Suppressing Autophagy in NQO1‐Positive Cancer Cells

Cell Biology International, Volume 49, Issue 5, Page 555-569, May 2025.
ABSTRACT Resistance to apoptosis‐inducing drugs frequently occurs in cancer cells, limiting their usefulness in ongoing cancer treatment. Despite ongoing efforts to overcome drug resistance, a definitive solution remains elusive. However, autophagy inhibition has been shown to enhance the effectiveness of some anticancer drugs and is a possible ...
Sahib Zada, Md Entaz Bahar, Wanil Kim, Deok Ryong Kim   +3 more
wiley   +1 more source

Hypoxia signaling in cancer: HIF-1α stimulated by COVID-19 can lead to cancer progression and chemo-resistance in oral squamous cell carcinoma (OSCC). [PDF]

Discov Oncol
Eghbalifard N, Nouri N, Rouzbahani S, Bakhshi M, Ghasemi Kahrizsangi N, Golafshan F, Abbasi F.   +6 more
europepmc   +1 more source

Modeling Stromal Cells Inside the Tumor Microenvironment of Ovarian Cancer: In Vitro Generation of Cancer‐Associated Fibroblast‐Like Cells and Their Impact in a 3D Model

MedComm, Volume 6, Issue 5, May 2025.
Conditioned medium from ovarian cancer cell lines influences fibroblast differentiation into distinct CAF subpopulations (iCAF, myCAF). A 3D model mimicking the tumor microenvironment was developed to study CAF roles in tumor spheroid growth and invasion.
Jacopo Romoli, Paola Chiodelli, Patrizia Bonassi Signoroni, Elsa Vertua, Clarissa Ferrari, Elisabetta Giuzzi, Alice Paini, Elisa Scalvini, Andrea Papait, Francesca Romana Stefani, Antonietta Rosa Silini, Ornella Parolini   +11 more
wiley   +1 more source

CD44 variant exons induce chemoresistance by modulating cell death pathways. [PDF]

Front Cell Dev Biol
Yanova M, Stepanova E, Maltseva D, Tonevitsky A.   +3 more
europepmc   +1 more source

Localized Microrobotic Delivery of Enzyme‐Responsive Hydrogel‐Immobilized Therapeutics to Suppress Triple‐Negative Breast Cancer

Small, Volume 21, Issue 18, May 5, 2025.
In response to enzymatic activity within the tumor microenvironment, remotely actuated microrobots designed for localized delivery of stimuli‐responsive hydrogels engineered to release chemotherapeutics (ChemoBots) are developed. The system leverages magnetic navigation for targeted localization and prolongsed drug release, achieving marked tumor ...
Mingzhen Tian, Meysam Keshavarz, Ali Anil Demircali, Bing Han, Guang‐Zhong Yang   +4 more
wiley   +1 more source

Retraction: GNB2L1 and its O-GlcNAcylation regulates metastasis via modulating epithelial-mesenchymal transition in the chemoresistance of gastric cancer. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

A Mutual Interaction Between GSTP1 and p53 Improves the Drug Resistance and Malignant Biology of Pancreatic Cancer

Cancer Science, Volume 116, Issue 5, Page 1268-1281, May 2025.
The specific role of Glutathione S‐transferase P1 (GSTP1) in pancreatic cancer (PC) has rarely been investigated. In current study, our results suggest that the positive feedback regulation of GSTP1 and wildtype p53 (wtp53) plays a significant role in cell proliferation, drug resistance, cell invasion and metastasis in PC.
Guosen Wang, Yi Cao, Tengcheng Hu, Zhengqing Cai, ChuanPing Chen, Qilong Geng, Xinyu Luo, Yang Liu, Weijie Wang, Jiabin Jin, Weiwei Sheng   +10 more
wiley   +1 more source

Understanding microRNA-Mediated Chemoresistance in Colorectal Cancer Treatment. [PDF]

Int J Mol Sci
Valenzuela G, Contreras HR, Marcelain K, Burotto M, González-Montero J.   +4 more
europepmc   +1 more source