Results 221 to 230 of about 149,400 (379)

Increased Survivin Expression Confers Chemoresistance to Tumor-Associated Endothelial Cells [PDF]

, 2008
Jenilyn J. Virrey, Shengxi Guan, Wěi Li, Axel H. Schönthal, Thomas C. Chen, Florence M. Hofman   +5 more
openalex   +1 more source

First‐line serplulimab plus chemotherapy in extensive‐stage small‐cell lung cancer: Updated results and biomarker analysis from the ASTRUM‐005 randomized clinical trial

Cancer Communications, EarlyView.
Abstract Background The ASTRUM‐005 study previously demonstrated a significant overall survival (OS) benefit with serplulimab (a programmed death 1 inhibitor) plus chemotherapy versus chemotherapy alone in previously untreated extensive‐stage small‐cell lung cancer (ES‐SCLC).
Ying Cheng, Shuang Zhang, Liang Han, Lin Wu, Jun Chen, Peiyan Zhao, Hongmei Sun, Guilan Wen, Yinghua Ji, Anastasia Zimina, Jianhua Shi, Zhijie Pan, Jinsheng Shi, Xicheng Wang, Yuansong Bai, Tamar Melkadze, Yueyin Pan, Xuhong Min, Maksym Viguro, Xingya Li, Yanqiu Zhao, Junquan Yang, Tamta Makharadze, Ekaterine Arkania, Haoyu Yu, Jing Li, Fang Yang, Xinyi Yang, Chen Ling, Qingyu Wang, Yongqiang Shan, Jun Zhu, the ASTRUM‐005 Study Group   +32 more
wiley   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Secondary BRCA1 and BRCA2 alterations and acquired chemoresistance [PDF]

, 2008
Weixin Wang, William D. Figg
openalex   +1 more source

SIRT7‐Mediated MVP Desuccinylation Facilitates Tongue Squamous Cell Carcinoma Progression by Activating JAK2/STAT3 Pathway

Cell Biology International, EarlyView.
ABSTRACT Major vault protein (MVP) plays a contributing role in multifarious cancers, and then its role in Tongue squamous cell carcinoma (TSCC) is uncomprehending. This study aimed to investigate the regulatory effect of MVP on malignant behavior of TSCC cells and its mechanism. We first pointed out the abnormal upregulation of MVP in tumor tissues by
Zhuo Zhang, Tingting Guo, Xiangyu Zhao
wiley   +1 more source

Glioblastoma Cancer Stem Cells Exhibit Chemoresistance with Overexpression of Multidrug Resistance Gene BCRP-1

, 2005
John S. Yu, Gentao Liu, Dwain Morris-Irvin, Keith L. Black   +3 more
openalex   +1 more source

Biphasic pulses enhance bleomycin efficacy in a spontaneous canine genital tumor model of chemoresistance: Sticker sarcoma [PDF]

, 2008
Enrico P. Spugnini, Ivan Dotsinsky, Nikolay Mudrov, Gennaro Citro, Alfredo D’Avino, Alfonso Baldi   +5 more
openalex   +1 more source

Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes

Cell Biology International, EarlyView.
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio, Ariely Barbosa Leite, Ana Caroline de Castro Nascimento Sousa, Suellen Rodrigues Maran, Antoniel Augusto Severo Gomes, Elton J. R. Vasconcelos, Nilmar Silvio Moretti   +6 more
wiley   +1 more source

Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials

Exploration, EarlyView.
Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment, has been emerging as a key participant and driving factor in cancer. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral ...
Yanan Niu, Junya Feng, Jie Ma, Tixian Xiao, Wei Yuan   +4 more
wiley   +1 more source

Chemoresistance in breast tumors.

European journal of gynaecological oncology, 1991
Resistance to multiple chemotherapeutic agents is a common clinical problem in the treatment of cancer: such resistance may occur in primary therapy or be acquired during treatment. The most commonly used antineoplastic agents in the treatment of disseminated breast cancer are adriamycin, methotrexate and cyclophosphamide.
GIAI M., BIGLIA, Nicoletta, SISMONDI, Piero   +2 more
openaire   +2 more sources