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Natural Polyphenols in Cancer Chemoresistance
Nutrition and Cancer, 2016Resistance to chemotherapy remains a major impediment to the management of most types of cancer. Both intrinsic and acquired drug resistance are mediated by several cellular and molecular mechanisms, including alternative growth-signaling pathways unaffected by specific therapies, alterations in the tumor microenvironment (e.g., hypoxia and ...
Saad A, Hussain +5 more
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Cancer Stem Cell Epigenetics And Chemoresistance
Epigenomics, 2009Cancer stem cells (CSCs) are thought to sustain cancer progression, metastasis and recurrence after therapy. There is in vitro and in vivo evidence supporting the idea that CSCs are highly chemoresistant. Epigenetic gene regulation is crucial for both stem cell biology and chemoresistance.
CREA F, DANESI, ROMANO, FARRAR WL
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KRAS degradation averts PDAC chemoresistance
Nature CancerEffectively targeting deregulated KRAS signaling remains an unmet clinical need, as current approaches commonly lead to the development of chemoresistance in clinical settings. ADAM9-mediated lysosomal KRAS degradation is now shown to counteract PDAC chemoresistance independently of mutational status.
Laura Leonhardt, Matthias Hebrok
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Tunneling Nanotubes: Implications for Chemoresistance
Tunneling nanotubes (TNTs) are thin, membranous protrusions that connect cells and allow for the transfer of various molecules, including proteins, organelles, and genetic material. TNTs have been implicated in a wide range of biological processes, including intercellular communication, drug resistance, and viral transmission. In cancer, they have beenSanyukta, Padmanabhan +3 more
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