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Hypomethylation of the PXR gene promoter drives its overexpression in cisplatin-resistant EOC. [PDF]
Discov OncolWang J +5 more
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Hypoxic conditions confer chemoresistance to crizotinib but not to imatinib in chronic myeloid leukemia cells. [PDF]
Hematol Transfus Cell TherAvinery L +4 more
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Evaluation of Circulating Tumor DNA as a Biomarker for Chemoresistance in Colorectal Cancer.
J Pharm Bioallied SciLakshmi KR +4 more
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Extracellular Vesicles in Chemoresistance
2021Chemotherapy represents the current mainstay therapeutic approach for most types of cancer. Despite the development of targeted chemotherapeutic strategies, the efficacy of anti-cancer drugs is severely limited by the development of drug resistance. Multidrug resistance (MDR) consists of the simultaneous resistance to various unrelated cytotoxic drugs ...
Gabriele, De Rubis, Mary, Bebawy
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Molecular and Cellular Biochemistry, 2008
Despite improved knowledge and advanced treatments of gliomas, the overall survival rate for glioma patients remains low. Gliomas comprise of significant cell heterogeneity that contains a large number of multidrug resistant (MDR) phenotypes and cancer stem cells (CSCs), a combination that may contribute to the resistance to treatment.
Chen, Lu, Amal, Shervington
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Despite improved knowledge and advanced treatments of gliomas, the overall survival rate for glioma patients remains low. Gliomas comprise of significant cell heterogeneity that contains a large number of multidrug resistant (MDR) phenotypes and cancer stem cells (CSCs), a combination that may contribute to the resistance to treatment.
Chen, Lu, Amal, Shervington
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Chemoresistance in falciparum malaria
Trends in Parasitology, 2003Tropical countries increasingly face the burden of drug resistance in Plasmodium falciparum infections. Malaria-related mortality of African children rises in contrast to the decline of the overall mortality of children under five years of age in sub-Saharan Africa within the past four decades.
Jürgen, May, Christian G, Meyer
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Fatty acids in cancer chemoresistance
Cancer Letters, 2023Despite the remarkable clinical success of immunotherapy and molecular targeted therapy in patients with advanced tumors, chemotherapy remains the most commonly used treatment for most tumor patients. Chemotherapy drugs effectively inhibit tumor cell proliferation and survival through their remarkable mechanisms.
Jiale Qin +6 more
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2013
Glioma remains one of the most aggressive and lethal form of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor with a median overall survival of just over 1 year. Most patients would die of tumour recurrences because of their tumours’ intrinsic or acquired resistance ...
Sun, S, Leung, GKK, Lee, D
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Glioma remains one of the most aggressive and lethal form of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor with a median overall survival of just over 1 year. Most patients would die of tumour recurrences because of their tumours’ intrinsic or acquired resistance ...
Sun, S, Leung, GKK, Lee, D
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Targeting lineage plasticity overcomes chemoresistance
Cancer Cell, 2022In this issue of Cancer Cell, Wang et al. reveal that chemoresistant muscle-invasive bladder cancer is associated with partial squamous differentiation. Targeting of Cathepsin H overcomes this chemotherapy-induced semi-squamatization and promotes terminal squamous differentiation and tumor suppression.
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