Results 291 to 300 of about 136,885 (362)

Phosphatidylcholine and CHPT1 as Central Drivers of Chemoresistance in Colorectal Cancer: Lipidomic and Functional Insights. [PDF]

Cells
Mialhe A, Pais de Barros JP, Hermetet F, Limagne E, Ghiringhelli F, Aires V, Delmas D.   +6 more
europepmc   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Marrow leptin-LEPR signaling rewires mitochondrial oxidative metabolism to confer chemoresistance in acute myeloid leukemia. [PDF]

Cell Death Dis
Liao X, Dai W, Xu X, Cai D, Tan M, Wang Z, Huang Y, Hou D, Liu J, Wang L, Wang J, Wang X, Zhang S, Lin X, Huang H.   +14 more
europepmc   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Role of non-coding RNAs in O⁶-methylguanine-DNA methyltransferase-positive glioblastoma (Review). [PDF]

Oncol Lett
Guo Y, Guo J, Xiao W, Lu Y.
europepmc   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione-Mediated Stemness Maintenance. [PDF]

Adv Sci (Weinh)
Li Z, Meng C, Shen G, Shan Y, Wang J, Abudukeremu D, Zhao R, Ni B, Xu C, Guo X, Yu J, Wang K, Yang S, Li Y, Xie Y, Zhou T, Hao J, Wang X.   +17 more
europepmc   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

IGLC3^- tumor cells drive chemoresistance in colorectal cancer by polarizing SPP1⁺ macrophages via the CD44-Wnt-BTF3 axis. [PDF]

Front Immunol
Yan F, Shi Y, Wang H, Chen B, Sheng K, Wu J, Zhang W, Wang H, Li X.   +8 more
europepmc   +1 more source

Photodynamic priming (PDP) targets platinum resistance from chronic perfluoroalkyl substances (PFAS) exposure in ovarian cancer cells

Photochemistry and Photobiology, EarlyView.
PFAS are environmental contaminants that induce chemoresistance in ovarian cancer cells. This study evaluated BPD‐PDP or ALA‐PpIX‐PDP in combination with carboplatin or doxorubicin to overcome PFAS‐induced chemoresistance in two cell cohorts: (i) PFAS chronically‐exposed and (ii) PFAS outgrown cells (which underwent a “recovery period” after chronic ...
Brittany P. Rickard, Meghan M. Dillon, Lauren A. Sapienza‐Lundie, Suzanne E. Fenton, Imran Rizvi   +4 more
wiley   +1 more source