Results 281 to 290 of about 136,885 (362)

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Correction to "Identification of a Crosstalk Among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance". [PDF]

Adv Sci (Weinh)
europepmc   +1 more source

Autophagy initiation inhibition combined with chemotherapy reverses drug resistance in oral cancer. [PDF]

Discov Oncol
Li B, Li J, Li S.
europepmc   +1 more source

Targeting the ODC1-YBX1 axis reverses gastric cancer chemoresistance via transcriptional control of SLC7A11-mediated ferroptosis

Ruiqi Li, Shantanu Baral, Fanyu Zhao, Chenkai Zhang, Jie Zhou, Ben Li, Yifan Cheng, Dengyang Fang, Zijie Xu, Yayan Fu, Jianyue Ding, Zhen Tian, Shuai Zhao, Yì Wáng, Mengli Zi, Longhe Sun, Xuetong Jiang, Qiannan Sun, Daorong Wang   +18 more
openalex   +1 more source

Management of Primary Refractory Diffuse Large B‐Cell Lymphoma in Patients Unsuitable for CAR T‐Cell Therapy

European Journal of Haematology, EarlyView.
ABSTRACT Primary refractory Diffuse Large B‐Cell Lymphoma is associated with poor outcomes and limited responsiveness to conventional salvage therapies. Although CAR T‐cell therapy represents the standard of care in this setting, a substantial proportion of patients cannot receive it despite meeting disease‐related criteria. In this review, “unsuitable”
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Valproate reactivates HTLV-1 tax and reduces ABCB1/MDR1 expression in PBMCs derived from ATLL patients. [PDF]

Front Oncol
Mourouvin C, Tram J, Marty L, Marie-Delcasse A, Belrose G, Pluta A, Césaire R, Hélias P, Baccini V, Peloponese JM.   +9 more
europepmc   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Arteannuin B Inhibits NSCLC Cells via Regulating miR-194-3p/CLDN2 Axis. [PDF]

Cancer Med
He TS, Chen RH, Feng J, Zhang Q, Li XL, Han JH, Chen TZ, Yu RM, Song LY, Huang WJ.   +9 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source