Results 271 to 280 of about 136,885 (362)

SLPI/FBW7/c‐Myc Axis Reduces Gemcitabine Sensitivity in PDAC by Enhancing Glycolysis and Impairing NK Cell Immunity

Cancer Science, EarlyView.
SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen, Xin Li, Weixiong Zhu, Yanxi Mu, Guoqing Zhang, Youheng Zhang, Yusheng Cheng, Wence Zhou   +7 more
wiley   +1 more source

Natural Products Targeting Key Molecular Hallmarks in Gastric Cancer: Focus on Apoptosis, Inflammation, and Chemoresistance. [PDF]

Int J Mol Sci
Simancas-Racines D, Cagua-Ordoñez J, Angamarca-Iguago J, Parise-Vasco JM, Reytor-González C.   +4 more
europepmc   +1 more source

Advancements in Inorganic Chiral Nanomaterials for Anti‐Tumor Immunotherapy

Cancer Science, EarlyView.
Schematic illustration of how inorganic chiral nanomaterials enhance immune activation to promote tumor cell elimination through targeted delivery, immunogenic cell death, and immune microenvironment modulation. ABSTRACT While the past decade has witnessed unprecedented technological advancements, cancer remains a major health threat, with conventional
Siyu Chen, Qian Tang, Xiqian Chen, Yinghao Liang, Jin Qiu, Yongmei Liao, Changqiang Li, Hongru Yu, Fang Xie, Zongjunlin Liu   +9 more
wiley   +1 more source

Klebsiella pneumoniae LPS drives stromal-mediated repression of p53 and colorectal cancer chemoresistance. [PDF]

Cell Death Dis
Fragkoulis K, Łasut-Szyszka B, Végvári Á, Ayona D, Saei AA, Aschtgen MS, Peuget S.   +6 more
europepmc   +1 more source

MYC Addiction as a Targetable Vulnerability in Nelarabine‐Resistant T‐Cell Acute Lymphoblastic Leukemia

Cancer Science, EarlyView.
MYC drives nelarabine resistance in T‐ALL via a hyperactive transcriptional program. Pharmacological degradation of BET proteins dismantles this addiction, restoring drug sensitivity and extending survival in vivo. ABSTRACT Acquired resistance represents a fundamental obstacle limiting the long‐term efficacy of cancer chemotherapy.
Jingjing Gao, Chunxu Lin, Suchang Chen, Qi Mo, Chu Bao, Huali Deng, Ziyin Chen, Weichao Hao, Luyong Zhang, Min Wei   +9 more
wiley   +1 more source

ARTS Confers Chemoresistance of Breast Cancer by Inducing Apoptosis-Dependent Autophagy via Livin-MDM2-p53 Pathway. [PDF]

Research (Wash D C)
Wang H, Guo Q, Shen Y, Ding K, Chen Y, Wang X, Huang X, Wu Z.   +7 more
europepmc   +1 more source

MAP17 Enhances Chemoresistance and Tumorigenicity of Glioblastoma‐Initiating Cells via the Canonical NF‐кB Pathway

Cancer Science, EarlyView.
MAP 17 is identified as highly expressed in TMZ‐resistant glioblastoma‐initiating cells (GICs). MAP17 enhances GIC proliferation, TMZ resistance, and tumorigenicity through NF‐κB/RELA‐dependent BCL2 upregulation. ABSTRACT Glioblastoma (GBM) is the most common malignant brain tumor in adults.
Shenshen Dou, You Lee Son, Toru Kondo
wiley   +1 more source

Correction to "Extracellular vesicle-LncRNA HOTAIR modulates esophageal cancer chemoresistance and immune microenvironment via miR-375/CDH2 pathway". [PDF]

J Cell Commun Signal
europepmc   +1 more source

OSMR coordinates a self-perpetuating circuit linking chemoresistance and neutrophil-driven immunosuppression in gastric cancer. [PDF]

Neoplasia
Wei D, Chen J, Bai F, Li D, Liu J, Dou H, Lei Y, Zhang Y, Zhang B, Pang Y, Cao C, Yang T, Han J, Cao T.   +13 more
europepmc   +1 more source

Metabolic Vulnerabilities of Temozolomide-Resistant Glioblastoma Cells: Implications for Targeted Therapies and Overcoming Chemoresistance [PDF]

Meitham Amereh, Amir Seyfoori, Shahla Shojaei, Sarah Lane, Tian Zhao, Mahdieh Shokrollahi Barough, Julian J. Lum, Patrick B. Walter, Mohsen Akbari   +8 more
openalex   +1 more source