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Autocrine mechanisms of cancer chemoresistance
Seminars in Cell & Developmental Biology, 2018An ever-increasing number of studies highlight the role of cancer secretome in the modification of tumour microenvironment and in the acquisition of cancer cell resistance to therapeutic drugs. The knowledge of the mechanisms underlying the relationship between cancer cell-secreted factors and chemoresistance is becoming fundamental for the ...
BUTERA, GIOVANNA +2 more
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Mitochondrial dysfunction in cancer chemoresistance
Biochemical Pharmacology, 2014Mitochondrial dysfunction has been associated with cancer development and progression. Recent evidences suggest that pathogenic mutations or depletion of the mitochondrial genome can contribute to development of chemoresistance in malignant tumors. In this review we will describe the current knowledge on the role of mitochondrial dysfunction in the ...
Guaragnella N, Giannattasio S, Moro L
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Leishmaniasis: efflux pumps and chemoresistance
International Journal of Antimicrobial Agents, 2003Resistance of parasitic protozoa such as Leishmania to therapeutic drugs continues to escalate in developing countries. Treatment programs for human leishmaniasis are still based on pentavalent antimonials but resistance to these compounds has been a persistent problem.
Clara, Leandro, Lenea, Campino
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Isolation of Chemoresistant Cell Subpopulations
2016Chemoresistance is a major challenge for cancer therapy and drives tumor relapse. The emergence, within the treated tumor mass, of specific cancer cell subpopulations endowed with high tolerance to the microenvironment stress induced by therapy is being growingly recognized as a mechanism of tumor progression. To obtain detailed information with regard
Claudia, Canino, Mario, Cioce
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Chemoresistance in rat ovarian tumours
European Journal of Cancer and Clinical Oncology, 1991In a cisplatin resistant subline (O-342/DPP) of an intraperitoneally growing transplantable rat ovarian tumour (O-342), intracellular glutathione (GSH) was approximately doubled (mean [S.E.] 1.5 [0.26] vs. 0.8 [0.2] nmol/10(6) cells). GSH reductase activity was higher (30.64 [4.07] vs.
W J, Zeller +5 more
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Natural Polyphenols in Cancer Chemoresistance
Nutrition and Cancer, 2016Resistance to chemotherapy remains a major impediment to the management of most types of cancer. Both intrinsic and acquired drug resistance are mediated by several cellular and molecular mechanisms, including alternative growth-signaling pathways unaffected by specific therapies, alterations in the tumor microenvironment (e.g., hypoxia and ...
Saad A, Hussain +5 more
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Cancer Stem Cell Epigenetics And Chemoresistance
Epigenomics, 2009Cancer stem cells (CSCs) are thought to sustain cancer progression, metastasis and recurrence after therapy. There is in vitro and in vivo evidence supporting the idea that CSCs are highly chemoresistant. Epigenetic gene regulation is crucial for both stem cell biology and chemoresistance.
CREA F, DANESI, ROMANO, FARRAR WL
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KRAS degradation averts PDAC chemoresistance
Nature CancerEffectively targeting deregulated KRAS signaling remains an unmet clinical need, as current approaches commonly lead to the development of chemoresistance in clinical settings. ADAM9-mediated lysosomal KRAS degradation is now shown to counteract PDAC chemoresistance independently of mutational status.
Laura Leonhardt, Matthias Hebrok
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