Results 91 to 100 of about 71,798 (273)

CCL2 nitration is a negative regulator of chemokine-mediated inflammation. [PDF]

, 2017
Chemokines promote leukocyte recruitment during inflammation. The oxidative burst is an important effector mechanism, this leads to the generation of reactive nitrogen species (RNS), including peroxynitrite (ONOO).
Ali, Simi, Barker, Catriona E, Kirby, John A, Lortat-Jacob, Hugues, O'Boyle, Graeme, Sheerin, Neil S, Thompson, Sarah   +6 more
core   +2 more sources

Chemotaxis of Polymorphonuclear Leukocytes by Protein A of the Staphylococcus

Experimental Biology and Medicine, 1970
SummaryProtein A, a component of staphylococcal cell wall in the presence of fresh human serum is highly chemotactic in vitro for human polymorphonuclear leukocytes. Chemotaxis is dependent upon heat-labile factors, presumably complement within serum.
Göran Kronvall, R. E. Anderson, Ralph C. Williams, R. L. Harvey, Gary M. Troup   +4 more
openaire   +3 more sources

Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial Infection

Advanced Science, EarlyView.
SummaryThis study constructs a single‐cell immune atlas of Nile tilapia across multiple time points during Streptococcus agalactiae infection, revealing dynamic immune cell responses and subtype transitions. It identifies a conserved IFNr‐STAT1‐IL8 axis driving il8+ neutrophils activation and antibacterial function, supported by cross‐species ...
Xue Zhai, Minghao Zhang, Kang Li, Wei Li, Xiaolong Li, Wa Gao, Zhaosheng Sun, Dan Huang, Songqian Huang, Mingli Liu, Zhichao Wu, Jun Zou, Liangbiao Chen, Jialong Yang, Peng Hu   +14 more
wiley   +1 more source

Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes [PDF]

, 2020
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine that prompts the proliferation of bone marrow-derived macrophages and granulocytes.
Esmaeil, Nafiseh, Lotfi, Noushin, Rostami, Mohamad, Zhang, Guang-Xian   +3 more
core   +2 more sources

The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]

, 2018
Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi, Burgoyne, Paul, Burt, Claire L., Fraser, Alasdair R., Graham, Gerard J., Hansell, Christopher A.H., Hayes, Alan J., Lee, Kit Ming, Macleod, Megan K.L., Medina-Ruiz, Laura, Nibbs, Robert J.B., Pingen, Marieke, Wilson, Gillian J.   +12 more
core   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, EarlyView.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

EFFECT OF CERULOPLASMIN THE QUANTITATIVE COMPOSITION AND FUNCTIONAL ACTIVITY OF LEUKOCYTES IN ACUTE PHYSICAL LOAD SUBMAXIMAL POWER

Acta Biomedica Scientifica, 2012
In experiments on animals have shown that the use of ceruloplasmin in acute submaximal exercise capacity leads to an increase in neutrophilic leukocytes pool with a change in their functional activity.
E. N. Ermolayeva, L. V. Krivokhizhina, E. F. Surina-Marysheva   +2 more
doaj  

Leukotriene B₄-loaded microspheres: a new therapeutic strategy to modulate cell activation

BMC Immunology, 2008
Background Leukotriene B4 (LTB4) is a potent inflammatory mediator that also stimulates the immune response. In addition, it promotes polymorphonuclear leukocyte phagocytosis, chemotaxis, chemokinesis and modulates cytokines release.
Sanz Maria J, Soares Edson G, Jose Peter J, Sorgi Carlos A, Rius Cristina, Piqueras Laura, Nicolete Roberto, Faccioli Lúcia H   +7 more
doaj   +1 more source

Polymorphonuclear leukocyte functions enhanced by chemotaxis [PDF]

Journal of Korean Medical Science, 1992
Human polymorphonuclear leukocytes (PMN) migrate into tissues in response to chemoattractants, yet it is not known whether this process alters the functional capabilities of the PMN. Using recombinant human interleukin-8 (rHIL-8, 100 ng/ml) as a stimulus, we compared a population of PMN that migrated through a polyvinylpyrrolidone-coated polycarbonate ...
openaire   +3 more sources

Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells

Advanced Science, EarlyView.
Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho, Su Min Kim, Jiyeon Lee, Oh Chan Kwon, Wonjin Woo, Eunji Lee, Hyo Jin Park, Yeongun Lee, So Hee Dho, Tae‐Kyung Kim, Min‐Chan Park, Richard A. Flavell, Lark Kyun Kim   +12 more
wiley   +1 more source