Results 91 to 100 of about 65,117 (210)

Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration. [PDF]

, 2017
Hereditary epidermolysis bullosa (EB) is associated with skin blistering and the development of chronic nonhealing wounds. Although clinical studies have shown that cell-based therapies improve wound healing, the recruitment of therapeutic cells to ...
Alexeev, Vitali, Fortuna, Giulio, Igoucheva, Olga, Mukhtarzada, Lila, Palisson, Francis, Salas-Alanis, Julio Cesar, South, Andrew P., Uitto, Jouni   +7 more
core   +1 more source

From Monotherapy to Adjunctive Therapies: Application of Dermocosmetics in Acne Management Across Australia and New Zealand

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Acne vulgaris is a globally prevalent dermatological disease, with its severity ranging from mild to severe. While moderate to severe acne often requires topical or systemic pharmaceutical therapy, mild to moderate acne may be managed with dermocosmetics, which are over‐the‐counter skincare agents with active ingredients that target acne ...
Ryan De Cruz, Rebecca Nguyen, Peggy Chen, Delphine Kerob, Kurt Gebauer, Anneliese Willems, Philip Tong, Michael Lee   +7 more
wiley   +1 more source

Intravascular Leukocyte Chemotaxis: The Rules of Attraction

, 2012
The security system of the body against pathogenic invaders includes leukocytes that efficiently scan the organism. Leukocytes within the vasculature utilize the comprehensive circulatory system to examine the blood vessels of the entire body for signs of e.g. bacteria displayed on vascular endothelial cells.
Sara Massena, Mia Phillipson
openaire   +4 more sources

Efficacy of IDOR‐1117‐2520, a novel, orally available CCR6 antagonist in preclinical models of skin dermatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose The chemokine receptor CCR6 guides pathogenic T17 cells, implicated in autoimmune diseases including psoriasis, to sites of inflammation via the chemokine CCL20. Therefor, pharmacological inhibition of CCR6+ immune cell migration provides a novel therapeutic approach.
Paulina Kulig, Pijus Brazauskas, Madeleine Suffiotti, Emilie Raoult, Ulrike Babilonski, Bérengère Renault, Ursula Grieder, Enrico Vezzali, Peter Blattmann, Marianne M. Martinic, Mark J. Murphy   +10 more
wiley   +1 more source

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. [PDF]

, 2019
Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown.
Edgerton, V Reggie, Hara, Masamitsu, Harimaya, Katsumi, Inoue, Kazuhide, Iwamoto, Yukihide, Kijima, Ken, Kobayakawa, Kazu, Kubota, Kensuke, Masuda, Takahiro, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Ohkawa, Yasuyuki, Okada, Seiji, Ozato, Keiko, Saito, Takeyuki, Tamaru, Tetsuya, Tamura, Tomohiko, Tsuda, Makoto, Yokota, Kazuya, Yoshizaki, Shingo   +19 more
core   +1 more source

Airway Basal Stem Cells Inflammatory Alterations in COVID‐19 and Mitigation by Mesenchymal Stem Cells

Cell Proliferation, EarlyView.
Airway basal stem cells derived from COVID‐19 patients demonstrated pronounced goblet cell hyperplasia, inflammatory responses and tendencies toward fibrosis. Co‐culture with mesenchymal stem cells (MSCs) notably reduced these pathological changes, likely due to MSCs' regulatory effects on the interferon signalling pathway.
Sheng Du, Jing Jin, Chunli Tang, Zhuquan Su, Lulin Wang, Xinyuan Chen, Mengni Zhang, Yiping Zhu, Jiaojiao Wang, Chunrong Ju, Xinyu Song, Shiyue Li   +11 more
wiley   +1 more source

Bosutinib mitigates inflammation in experimental sepsis

European Journal of Clinical Investigation, EarlyView.
Abstract Background Sepsis, a leading cause of death globally, lacks targeted and effective treatment. Its pathophysiology involves unbalanced inflammation, marked by a high release of inflammatory mediators, leukocyte recruitment, vascular changes and dysfunction of the nervous and respiratory systems. Src family tyrosine kinases (SFK) play a critical
C. M. C. Cunha, V. H. P. Abreu, V. Estato, G. M. V. Soares, B. P. T. Moraes, G. P. Oliveira, J. D. Silva, P. L. Silva, R. Immler, P. R. Rocco, M. Sperandio, A. R. Silva, P. T. Bozza, H. C. Castro‐Faria‐Neto, C. F. Gonçalves‐de‐Albuquerque   +14 more
wiley   +1 more source

Shape oscillations of human neutrophil leukocytes: characterization and relationship to cell motility [PDF]

, 1996
When neutrophil leukocytes are stimulated by chemotactic factors or by substratum contact, they change their shape. Shape changes are a prerequisite for cellular migration and typically involve the extrusion of thin, veil-like lamellipods and the ...
Coates, Thomas D., Deranleau, David A., Ehrengruber, Markus U.   +2 more
core  

Inflammation and epithelial–mesenchymal transition in a CFTR‐depleted human bronchial epithelial cell line revealed by proteomics and human organ‐on‐a‐chip

The FEBS Journal, EarlyView.
Proteomic analysis of cystic fibrosis transmembrane conductance regulator knockout (CFTR‐KO) clones of 16HBE14o‐ cells showed altered pathways linked to inflammation, polymorphonuclear leukocyte (neutrophil) recruitment, and epithelial–mesenchymal transition.
Domenico Mattoscio, Luis A. Baeza, Haiqing Bai, Tommaso Colangelo, Simone Castagnozzi, Marta Marzotto, Maria Concetta Cufaro, Virginia Lotti, Yu‐Chieh Yuan, Matteo Mucci, Longlong Si, Mariachiara Zuccarini, Maria Tredicine, Simona D'Orazio, Damiana Pieragostino, Piero Del Boccio, Claudio Sorio, Marco Trerotola, Mario Romano, Roberto Plebani   +19 more
wiley   +1 more source

Tracing the molecular landscape of diabetic nephropathy: Insights from machine learning and experiment verification

Journal of Diabetes Investigation, EarlyView.
Diabetic nephropathy (DN) is a major complication of diabetes, leading to end‐stage renal disease. This study identified 109 differentially expressed genes (DEGs) and validated LOX as a novel diagnostic biomarker through integrated bioinformatics and experimental analysis.
Shahad W. Kattan, Ahmed M. Basri, Mohammad H. Alhashmi, Amany I. Almars, Reem Hasaballah Alhasani, Ifat Alsharif, Ikhlas A. Sindi, Ahmad H. Mufti, Iman S. Abumansour, Nasser A. Elhawary, Aishah Abdullah Qahtani, Hailah M. Almohaimeed   +11 more
wiley   +1 more source