Results 111 to 120 of about 65,117 (210)

Neutrophils at the Crossroads of Inflammatory Bowel Disease and Atherosclerosis: A State-of-the-Art Review. [PDF]

Cells
Genkel V, Zaripova Y, Kuznetsova A, Sluchanko A, Minasova A, Zotova M, Saenko A, Savochkina A, Dolgushina A.   +8 more
europepmc   +1 more source

ALX/FPR2 Contributes to Serum Amyloid A‐Induced Lung Neutrophil Recruitment Following Acute Ozone Exposure

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Ozone (O3) is a toxic air pollutant that causes respiratory inflammation and can cause hospitalization. The goal of this study was to determine if the G protein‐coupled receptor, ALX/FPR2, is required for the initiation of inflammation in the lungs following O3 exposure.
Michael J. Yaeger, Tyson Ngatikaura, Natali Zecchino, Katelyn Dunigan‐Russell, Hannah B. Lovins, Evangeline Schott, Grace Hutton, Brett Saunders, Yan Lin, Junfeng (Jim) Zhang, Samuel J. Cochran, Rafia Virk, R. Ian Cumming, Salik Hussain, Robert M. Tighe, Saame Raza Shaikh, Kymberly M. Gowdy   +16 more
wiley   +1 more source

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinhui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
wiley   +1 more source

Gulf War Illness Induced Sex-Specific Transcriptional Differences Under Stressful Conditions. [PDF]

Int J Mol Sci
Frank J, Tehrani L, Gamer J, Van Booven DJ, Ballarin S, Rossman R, Edelstein A, Uppalati S, Reuthebuck A, Collado F, Klimas NG, Nathanson L.   +11 more
europepmc   +1 more source

Targeting Splenic Myeloid Cells with Nanobiologics to Prevent Postablative Pancreatic Cancer Recurrence via Inducing Antitumor Peripheral Trained Immunity

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Using a preclinical pancreatic cancer model, we identified that tumor progression restructures splenic immunity via myeloid cell expansion. MDCa@RBC‐Alipo nanobiologics were engineered to epigenetically and metabolically reprogram splenic myeloid cells, alleviating post‐ablation immunosuppression.
Shengbo Wu, Weichen Xu, Xuexia Shan, Liping Sun, Shuo Liu, Xixi Sun, Shaoyue Li, Xiaodong Hou, Xiaowan Bo, Chengzhong Peng, Bin Huang, Huixiong Xu, Wenwen Yue   +12 more
wiley   +1 more source

Traffic jam in lung capillaries: inter-organ communication impedes gas exchange after acute kidney injury. [PDF]

J Clin Invest
Matt U, Herold S.
europepmc   +1 more source

Confinement by Liquid‐Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb‐Based Migration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Leukocytes sense mechanical cues provided by surrounding cells to regulate motility. Replicating the confining pressures applied by soft, elastic tissues in vitro is challenging. Here, the use of liquid‐liquid interfaces is introduced to model forces exerted by surrounding cells. Confining pressures are tunable by controlling interfacial curvature, and
Jonathan H. Schrope, Adam Horn, Kaitlyn Lazorchak, Clyde W. Tinnen, Jack J Stevens, Mehtab Farooqui, Tanner Robertson, Jiayi Li, David Bennin, Terry Juang, Adeel Ahmed, Chao Li, Anna Huttenlocher, David J Beebe   +13 more
wiley   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, Volume 12, Issue 21, June 5, 2025.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Precision‐Guided Stealth Missiles in Biomedicine: Biological Carrier‐Mediated Nanomedicine Hitchhiking Strategy

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou, Xinyue Wang, Deyu Zhang, Hanxiao Cui, Xiaorong Tian, Wei Du, Zhenghui Yang, Dongling Wan, Zhiwei Qiu, Chao Liu, Zhicheng Yang, Lizhihong Zhang, Qiusheng Yang, Xuefeng Xu, Wenhao Li, Dong Wang, Haojie Huang, Wencheng Wu   +17 more
wiley   +1 more source

Histological Evaluation of Subcutaneous Tissue Reactions to a Novel Bilayer Polycaprolactone/Silk Fibroin/Strontium Carbonate Nanofibrous Membrane for Guided Bone Regeneration: A Study in Rabbits

Clinical and Experimental Dental Research, Volume 11, Issue 3, June 2025.
ABSTRACT Objectives The selection of appropriate biomaterial for guided bone regeneration is challenging. The blending of polymers is a simple method to retain their characteristics and to compensate for the drawbacks of each component. The release of Sr+2 (strontium) ions from the polycaprolactone/strontium carbonate (PCL/SrC) nanocomposite is the ...
Lida Kheiri, Arash Golestaneh, Mehdi Mehdikhani, Sayed Mohammad Razavi, Niloofar Etemadi   +4 more
wiley   +1 more source