Results 191 to 200 of about 98,425 (307)

The dual non-competitive CXCR1/2 inhibitor ladarixin impairs neutrophil extravasation without altering intravascular adhesion. [PDF]

Haematologica
Napoli M, Sitaru S, Budke A, Kammerl A, Querner G, Immler R, Rohwedder I, Seifert S, Ferraro B, Weckbach L, Catz S, Aramini A, Amendola PG, Allegretti M, Bertini R, Pruenster M, Sperandio M.   +16 more
europepmc   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Keratin 17 enhances the chemotaxis of neutrophils through regulating CXCL1 secretion in keratinocytes via PI3K/AKT/NF-κB pathway in psoriasis. [PDF]

Chin Med J (Engl)
Xu J, Jin L, Zhang T, Zhuang Y, Zhu Z, Liu Y, Xiao Y, Wang L, Shao S, Dang E, Wang G, Li Q.   +11 more
europepmc   +1 more source

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, Volume 59, Issue 5, May 2026.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging. [PDF]

Front Aging Neurosci
Sun M, Wu C, Wu J, Liu L, Gu L, Wang Z, Yang X, Xu F.   +7 more
europepmc   +1 more source

Monocyte Chemokines Enhance Atherosclerotic Plaque Necrosis After Bacterial Kidney Infection

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Cardiovascular event rates rise after acute infections. After a single pyelonephritis episode in Ldlr−/− mice, atherosclerotic plaque necrotic core size increased, mediated by chemokine receptor CCR2‐induced monocyte mobilization from the bone marrow.
Lena Possenriede, Peyman Falahat, Marie Foerster, Georg W. Sendtner, Julia Miranda, Leonie Richard‐Stropahl, Uta Scheidt, Christian Kurts, Florian Wagenlehner, Ekaterina K. Koltsova, Sibylle von Vietinghoff   +10 more
wiley   +1 more source

Single-cell transcriptome analysis profiles cellular dynamics and transcriptional changes in diabetic wound tissues following ESWT treatment. [PDF]

Front Physiol
Li D, Wang Y, Wang Y, Sihao C, Wang L, Xin S, Ma Y.   +6 more
europepmc   +1 more source

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich, Martin Ullrich, Cathleen Haase‐Kohn, Robert Wodtke, Sebastian Braun, Maximilian Molitor, Bettina Hofmann, Dieter Steinhilber, Klaus Kopka, Evamarie Hey‐Hawkins, Jens Pietzsch, Markus Laube   +11 more
wiley   +1 more source

Exploring the mechanism of polymorphonuclear neutrophils against sepsis based on immune model. [PDF]

Ann Med
Liu C, Cai Y, Mou S.
europepmc   +1 more source

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

Advanced Healthcare Materials, Volume 15, Issue 15, 17 April 2026.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt, Chably Rachella, Charlotte Jaloux, Joshua Vorstenbosch, Adam Hart, Michael Tanzer, Geraldine Merle, Jake Barralet   +7 more
wiley   +1 more source