Results 201 to 210 of about 98,425 (307)

Decoding chemerin proteolytic processing and isoform signaling across disease contexts. [PDF]

iScience
Wang J, Deng J, Xiao T, Meng W.
europepmc   +1 more source

Predicting Macrophage Spatial Localization from Single‐Cell Transcriptomes to Uncover Disease Mechanisms

Advanced Science, Volume 13, Issue 21, 13 April 2026.
This study presents a machine‐learning framework entitled MERLIN that infers the microanatomical localization of macrophages from single‐cell transcriptomic data in structured organs such as the kidney and brain. Applying this method to existing datasets from models of acute kidney injury and diabetic nephropathy uncovered spatially resolved insights ...
Junping Yin, Qi Mei, Hans‐Joachim Paust, Ning Song, Yu Zhao, Daniela Klaus, Melanie Eichler, Yijun Hua, Jie Qin, Weiting Cheng, Christina K. Weisheit, Veronika Lukacs‐Kornek, Isis Ludwig‐Portugall, Sibylle von Vietinghoff, Christian F. Krebs, Johanna Klughammer, Ulf Panzer, Christian Kurts, Jian Li   +18 more
wiley   +1 more source

Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing

Advanced Science, Volume 13, Issue 23, 23 April 2026.
This study develops a PLGA@LA‐BMP4‐PG bilayer scaffold to address scar formation and appendage loss in skin repair. The piezoelectric PLA layer enhances cell migration via electric fields, while GelMA delivers LA promoting Tregs polarization and BMP4 inhibiting FBs differentiation.
Yiwen Yang, Mingjie Kuang, Jiacheng Shi, Ruiyan Li, Yuhan Zhang, Xinting Liu, Runtan Li, Yong Kang, Bin Yao, Shuquan Zhang, Xiaoyuan Ji   +10 more
wiley   +1 more source

Macrophage-derived CXCL8 as a mediator of inflammatory attacks in Meniere's disease. [PDF]

Front Immunol
Peng L, Zhu B, Li Y, Lan Y, Zhan X, Pan X, Li S, Yin S.   +7 more
europepmc   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Premature Neuroimmune and Redox-Inflammatory Breakdown at the Prodromal Stage in Male and Female Triple-Transgenic Alzheimer's Disease Mice. [PDF]

Diseases
Giménez-Llort L, Vida C, Félix J, Quer-Palomas S, Manassra R, De la Fuente M.   +5 more
europepmc   +1 more source

Developing a Single‐Cell Spatial Transcriptomics Workflow for In Vivo Evaluation of Implanted Biomaterials

Advanced Science, Volume 13, Issue 24, 27 April 2026.
This work establishes a standardized, high‐resolution spatial transcriptomics workflow for characterizing host responses to biomaterial implants. Using the 10× Xenium platform, the pipeline integrates spatial mapping, subclustering, and functional enrichment to resolve immune and stromal cell organization at single‐cell resolution, enabling ...
Alex H.P. Chan, Yunfei Hu, Billie Pardavi, Xueying Xu, Angus J. Grant, Steven G. Wise, Lipin Loo, Richard P. Tan   +7 more
wiley   +1 more source

SOX17-silenced HPAECs upregulate NF-κB-induced CXCL10 and CXCL11: implications for lymphocyte chemotaxis in SOX17-PAH. [PDF]

Sci Rep
Mahomed AS, Burke-Gaffney A, Moledina S, Toe QK, Shao D, Quinlan GJ, Rhodes CJ, Pease JE, Wort SJ.   +8 more
europepmc   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, Volume 13, Issue 22, 17 April 2026.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Teaching the laboratory assessment of neutrophil chemotaxis: a simulation-based approach for undergraduate immunology. [PDF]

Immunohorizons
Costabile M, Denyer G.
europepmc   +1 more source