Results 221 to 230 of about 98,425 (307)

Harnessing Tumor Organoids to Revolutionize Immunotherapy Research

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Immunotherapy has emerged as a revolutionary approach to cancer treatment, yet the lack of robust preclinical testing platforms impedes progress in this field. Tumor organoids, three‐dimensional structures derived from patient‐specific samples, differ from conventional models by faithfully recapitulating the histological, genetic, and ...
Zhen Wang, Peipei Yin, Shizhan Cui, Hui Liu, Dan Li, Yang Yu, Baoshan Cao, Xiaojuan Liu   +7 more
wiley   +1 more source

Photon and particle radiotherapy induce redundant modular chemotaxis of human lymphocytes. [PDF]

JCI Insight
Kraske JA, Allers MM, Smirnov A, Lenoir B, Ahmed A, Suarez-Carmona M, Hampel M, Krunic D, Tietz-Dalfuß A, Beikert T, Schneeweiss JM, Brons S, Albrecht D, Trinh T, Liu M, Giese NA, Glowa C, Liermann J, Lopez Perez R, Jäger D, Debus J, Halama N, Huber PE, Walle T.   +23 more
europepmc   +1 more source

Isoquercitrin Alleviates 5‐Fluorouracil‐Induced Intestinal Mucositis in Mice by Modulating Inflammation and Oxidative Stress

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT This study aimed to evaluate the role of isoquercitrin (ISO) in 5‐fluorouracil‐induced intestinal mucositis. The animals (6 animals/group) were divided into: vehicle (2% DMSO), 5‐fluorouracil (5‐FU) and groups receiving ISO (10, 50, or 100 mg/kg).
Lázaro de Sousa Fideles, Matheus da Silva Campelo, João Francisco Câmara Neto, Conceição da Silva Martins, João Erivan Façanha Barreto, Ícaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Maria Elenir Nobre Pinho Ribeiro   +8 more
wiley   +1 more source

Quantifying effects of neutrophil memory on migration patterns using microfluidic platforms and ODE modeling of the mechanistic molecular pathways [PDF]

, 2018
Boribong, Brittany P, Ciupe, Stanca, Jonea, Caroline N, Kadelka, Mirjam Sarah, Lenzi, Mark J, Li, Liwu   +5 more
core   +1 more source

The immunomodulatory potential of bradykinin signaling in autoimmune conditions. [PDF]

Front Immunol
Szaryńska M, Olejniczak-Kęder A.
europepmc   +1 more source

Construction of a Prognostic Risk Model for Helicobacter pylori Infection in Gastric Cancer Patients and Immunological Analysis

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Gastric carcinoma poses a significant global health challenge, often diagnosed late due to its similarity to chronic gastric conditions. Helicobacter pylori (Hp) infection plays a crucial role in gastric carcinogenesis through inflammation and the release of virulent products.
Zhiying Tian, Miao Su, Bin Yang, Zhaoyun Zhang, Li Zhang   +4 more
wiley   +1 more source

Editorial: Advancing research, clinical recognition, and targeted therapies for WHIM syndrome. [PDF]

Front Immunol
Geier CB.
europepmc   +1 more source

Inhibition of Transglutaminase 2 Preserves Blood–Brain Barrier Integrity and Improves Neurological Outcomes After Experimental Traumatic Brain Injury in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
The article unraveled that inhibition or knockdown of TGM2 can restore blood–brain barrier (BBB) permeability and ameliorate neurological deficits and cognitive dysfunction in a mouse model of traumatic brain injury (TBI). Mechanistically, TGM2 likely modulates the IL‐17 signaling pathway to regulate MMP9 expression, thereby affecting BBB permeability.
Jieru Yang, Lihan Zhang, Xiancheng Qiu, Jiyang Wang, Ruicheng Yan, Jiasen Ye, Jianhua Peng, Yong Jiang   +7 more
wiley   +1 more source

Platelet-rich plasma for treatment of knee osteoarthritis: a narrative review. [PDF]

Front Pain Res (Lausanne)
Patton SL, Gustafson K, Castinado M, Latif U, Sayed D, Khan TW, Lam CM.   +6 more
europepmc   +1 more source

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng‐Jun Hu, Claudia Mickael, Yen‐Rei Yu, Rubin M. Tuder, Kurt R. Stenmark   +9 more
wiley   +1 more source