Decoding pulmonary risk in childhood-onset still's disease: immunogenetic determinants and implications for risk stratification. [PDF]
Margoni A +3 more
europepmc +1 more source
This study has used integrated single‐cell RNA sequencing and Visium HD spatial transcriptomics to construct a high‐resolution immune cell atlas of human ascending thoracic aortic aneurysms (ATAA). The analysis reveals distinct immune cell composition and interactions in ATAA tissues, providing new insights into immune dysregulation and vascular ...
Ke Zhen +6 more
wiley +1 more source
Immature leukocyte and plasma-induced cell death reveal subclinical immune activation in EGPA patients in remission. [PDF]
Baggio C +12 more
europepmc +1 more source
Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice
In a neonatal mouse model of E. coli sepsis, depleting neonatal neutrophilic cells (NNC) increased mortality and systemic inflammation. The bacterial load increased slightly, and the immune cell populations remained unchanged. These findings suggest that NNC may play a role in controlling inflammation and protecting neonates from lethal sepsis ...
Julian Schwarz +8 more
wiley +1 more source
The role of platelet derivatives in regenerative medicine: biological foundations and translational perspectives. [PDF]
Mourão CF, Alves GG.
europepmc +1 more source
Expression of molecules related to the activation of NLRP3 inflammasomes and NIAHGs. (A) Immunoblot analysis of NLRP3, pro‐caspase‐1, caspase‐1 p20, and NIAHGs proteins in renal tissues from NC, eDN, and aDN patients. (B–E) Relative IL‐1β and IL‐18 levels across groups determined by RT‐qPCR (B, C) and ELISA (D, E).
Sheng Zhao +8 more
wiley +1 more source
The applicability of the Migratest® kit for evaluating the chemotactic activity of peripheral blood granulocytes in lambs supplemented with a multi-strain probiotic formulation (Lactobacillus, Bifidobacterium). [PDF]
Wójcik R, Tobolski D, Zwierzchowski G.
europepmc +1 more source
We calculated the infiltration profiles of 28 immune cells within psoriatic immune microenvironment through single‐sample gene set enrichment analysis (ssGSEA) algorithm based on the eleven psoriasis related microarray datasets. Five immune‐related genes CXCL8, CXCL9, CCL18, RGS1, and SAMSN1 are associated with psoriasis, and establish a predictive ...
Tingjin Zheng +7 more
wiley +1 more source
Manuka honey and its component, methyl syringate, shift neutrophil release profiles from pro-inflammatory while preserving pro-regenerative growth factor release <i>in vitro</i>. [PDF]
Main EN, Hall SC, Bowlin GL.
europepmc +1 more source
ABSTRACT Canine hepatocellular carcinoma (HCC) requires further molecular characterization to identify diagnostic and therapeutic targets, and to establish whether dogs with this condition can model the human disease. Accordingly, we aimed to identify differentially expressed genes (DEGs) in canine HCC and evaluate cross‐species transcriptomic ...
Mohammad Arif +8 more
wiley +1 more source

