Results 231 to 240 of about 69,950 (300)

Cancer IDO1‐Mediated Tryptophan–Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3‐dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific role in driving lung cancer–associated ...
Leng Han, Lingjie Jing, Xinting Zhu, Ciqin Li, Lu Bai, Yang Fang, Yuxuan Zhou, Dingyuan Bai, Jin Lu, Yonglong Han, Cheng Guo, Shumin Zhou, Quanjun Yang   +12 more
wiley   +1 more source

The role of NINJ1 in diseases. [PDF]

Cell Death Discov
Bao S, Chen F, Guo Z, Ding W, Gao F, Guo J.   +5 more
europepmc   +1 more source

DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS‐CoV‐2 Respiratory Infection Compromise Inflammation and Cellular Metabolism

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Extracellular vesicles from severe COVID‐19 airways carry depleted miRNAs and elevated DAMPs, reprogramming monocytes toward senescence, impaired metabolism, and predominantly reduced cytokine responses. However, they drive excess IL‐8 production, amplifying neutrophil recruitment and dysfunctional inflammation across the respiratory tract.
April Rees, Oliver Richards, Molly E Raikes, Megan Chambers, Sophie G Reed, Ceri Battle, Hannah Toghill, Luke Newey, Tyler J Joseph, Haiyan An, Hui Zhang, Iain Perry, Jason Webber, Nicholas Jones, Catherine A Thornton   +14 more
wiley   +1 more source

SOX17-silenced HPAECs upregulate NF-κB-induced CXCL10 and CXCL11: implications for lymphocyte chemotaxis in SOX17-PAH. [PDF]

Sci Rep
Mahomed AS, Burke-Gaffney A, Moledina S, Toe QK, Shao D, Quinlan GJ, Rhodes CJ, Pease JE, Wort SJ.   +8 more
europepmc   +1 more source

Decoding chemerin proteolytic processing and isoform signaling across disease contexts. [PDF]

iScience
Wang J, Deng J, Xiao T, Meng W.
europepmc   +1 more source

Teaching the laboratory assessment of neutrophil chemotaxis: a simulation-based approach for undergraduate immunology. [PDF]

Immunohorizons
Costabile M, Denyer G.
europepmc   +1 more source

Macrophage-derived CXCL8 as a mediator of inflammatory attacks in Meniere's disease. [PDF]

Front Immunol
Peng L, Zhu B, Li Y, Lan Y, Zhan X, Pan X, Li S, Yin S.   +7 more
europepmc   +1 more source

Premature Neuroimmune and Redox-Inflammatory Breakdown at the Prodromal Stage in Male and Female Triple-Transgenic Alzheimer's Disease Mice. [PDF]

Diseases
Giménez-Llort L, Vida C, Félix J, Quer-Palomas S, Manassra R, De la Fuente M.   +5 more
europepmc   +1 more source

Exploring the mechanism of polymorphonuclear neutrophils against sepsis based on immune model. [PDF]

Ann Med
Liu C, Cai Y, Mou S.
europepmc   +1 more source