Results 231 to 240 of about 98,425 (307)

Spatial and single‐cell RNA sequencing reveals the immune microenvironment of human ascending thoracic aortic aneurysms

open access: yesClinical and Translational Medicine, Volume 16, Issue 4, April 2026.
This study has used integrated single‐cell RNA sequencing and Visium HD spatial transcriptomics to construct a high‐resolution immune cell atlas of human ascending thoracic aortic aneurysms (ATAA). The analysis reveals distinct immune cell composition and interactions in ATAA tissues, providing new insights into immune dysregulation and vascular ...
Ke Zhen   +6 more
wiley   +1 more source

Immature leukocyte and plasma-induced cell death reveal subclinical immune activation in EGPA patients in remission. [PDF]

open access: yesInflamm Res
Baggio C   +12 more
europepmc   +1 more source

Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice

open access: yesEuropean Journal of Immunology, Volume 56, Issue 4, April 2026.
In a neonatal mouse model of E. coli sepsis, depleting neonatal neutrophilic cells (NNC) increased mortality and systemic inflammation. The bacterial load increased slightly, and the immune cell populations remained unchanged. These findings suggest that NNC may play a role in controlling inflammation and protecting neonates from lethal sepsis ...
Julian Schwarz   +8 more
wiley   +1 more source

Characterization of NLRP3 Inflammasome‐Associated Hub Genes in the Progression of Diabetic Nephropathy

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
Expression of molecules related to the activation of NLRP3 inflammasomes and NIAHGs. (A) Immunoblot analysis of NLRP3, pro‐caspase‐1, caspase‐1 p20, and NIAHGs proteins in renal tissues from NC, eDN, and aDN patients. (B–E) Relative IL‐1β and IL‐18 levels across groups determined by RT‐qPCR (B, C) and ELISA (D, E).
Sheng Zhao   +8 more
wiley   +1 more source

Experimental Validation of an Immune Cell Infiltration Signature in Psoriasis: Translating Computational Modeling to In Vivo Efficacy

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 8, April 2026.
We calculated the infiltration profiles of 28 immune cells within psoriatic immune microenvironment through single‐sample gene set enrichment analysis (ssGSEA) algorithm based on the eleven psoriasis related microarray datasets. Five immune‐related genes CXCL8, CXCL9, CCL18, RGS1, and SAMSN1 are associated with psoriasis, and establish a predictive ...
Tingjin Zheng   +7 more
wiley   +1 more source

Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross‐Species Transcriptomic Comparison With Human HCC

open access: yesMolecular Carcinogenesis, Volume 65, Issue 4, Page 523-536, April 2026.
ABSTRACT Canine hepatocellular carcinoma (HCC) requires further molecular characterization to identify diagnostic and therapeutic targets, and to establish whether dogs with this condition can model the human disease. Accordingly, we aimed to identify differentially expressed genes (DEGs) in canine HCC and evaluate cross‐species transcriptomic ...
Mohammad Arif   +8 more
wiley   +1 more source

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