Results 211 to 220 of about 69,950 (300)

Effect of C5a Receptor Antagonist on the Osteogenic Differentiation of Dental Pulp Stem Cells

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objective Complement component 5a (C5a) binding to its receptor (C5aR) can mediate pro‐inflammatory immune responses, which impairs osteogenic differentiation of dental pulp stem cells (DPSCs). The present study aimed to evaluate the regulatory effect of C5aR antagonist (W54011) on the osteogenic differentiation of DPSCs in an in vitro ...
Xiaohan Tan, Junlong Hu, Junhui Li, Zhuangying Chen, Xin Shi, Jie Liu, Mingyue Liu, Weiping Hu   +7 more
wiley   +1 more source

Integrative imaging and transcriptomics implicate neutrophils in microvascular no-reflow after stroke. [PDF]

J Neuroinflammation
Abbasi-Habashi S, Clarke M, Ma Y, Real MGC, Siegers GM, Jickling GC, Winship IR.   +6 more
europepmc   +1 more source

Development and functional adaptation of intestinal macrophages across the lifespan

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This article discusses intestinal macrophage development, including the influence of developmental origins and life stages; ontogeny and functional heterogeneity; preclinical and clinical evidence. Abstract Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional ...
Baha Mustafa, Elisa L Hill‐Yardin, Sarah J Spencer   +2 more
wiley   +1 more source

Glycosaminoglycan binding to soluble CX3CL1 impacts monocyte migration <i>in vitro</i>. [PDF]

Front Immunol
Ennemoser M, Peinsipp P, Novak T, Matteini C, Tauschmann D, Gerlza T, Kungl AJ.   +6 more
europepmc   +1 more source

Single‐cell profiling reveals peripheral blood immune landscape remodelling in breast cancer lymph node metastasis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
scRNA‐seq reveals pro‐metastatic neutrophil and exhausted T/NK subsets in BC patients with LN metastasis. Interferon‐stimulated neutrophils secrete LGALS9, drives T/NK cell exhaustion via HAVCR2. Neutralising LGALS9 restores T‐cell anti‐tumour activity, suggesting a novel therapeutic target.
Bo Chen, Kang Ma, Yunjie Wang, Liulu Zhang, Xinyue Feng, Cheng Long, Xuejing Tan, Kun Wang   +7 more
wiley   +1 more source

Integrated Network Pharmacology and Single-Cell Transcriptomics Reveal Transketolase as a Potential Target for the DanShen-DaHuang Herb Pair in Acute Kidney Injury. [PDF]

Int J Mol Sci
Zhang Y, Yang H, Li J, Wu X, Li L, Ye G, Zhang K, Zhong Z.   +7 more
europepmc   +1 more source

Multi‐omics reveals a novel Cxcr4+ subpopulation of alveolar macrophages and therapeutic effect of AMD3100 in mice with advanced silicosis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
The progression of silicosis‐associated fibrosis relies on a positive feedback loop mediated by crosstalk between Cxcr4+ macrophages and Cxcl12+ fibroblasts and the therapeutic potential of targeting the Cxcl12/Cxcr4 axis with AMD3100 as a novel strategy for treating silicosis.
Min Mu, Bing Li, Hangbing Cao, Yuanjie Zou, Ruiqing Yan, Fei Wang, Yehong Zhao, Zihao Xie, Miaomiao Du, Xiaolong Wu, Xinrong Tao, Jianhua Wang   +11 more
wiley   +1 more source

Keratin 17 enhances the chemotaxis of neutrophils through regulating CXCL1 secretion in keratinocytes via PI3K/AKT/NF-κB pathway in psoriasis. [PDF]

Chin Med J (Engl)
Xu J, Jin L, Zhang T, Zhuang Y, Zhu Z, Liu Y, Xiao Y, Wang L, Shao S, Dang E, Wang G, Li Q.   +11 more
europepmc   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging. [PDF]

Front Aging Neurosci
Sun M, Wu C, Wu J, Liu L, Gu L, Wang Z, Yang X, Xu F.   +7 more
europepmc   +1 more source