Results 211 to 220 of about 98,425 (307)

Sensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu, Ting Zhang, Yuqing Mu, Lili Li, Ju Jin, Kevin J Dudley, Wendong Gao, Donglin Cai, Fuhua Yan, Lan Xiao, Yin Xiao   +10 more
wiley   +1 more source

Lewis Y (Le^y) orchestrates leukocyte trafficking and inflammatory remodeling in leprosy patients from the Brazilian Amazon. [PDF]

Immunol Res
Almeida S, da Cruz EDRM, de Loiola RDSP, Corvelo TCO.   +3 more
europepmc   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, Volume 13, Issue 21, 13 April 2026.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

Chemokines in Pregnancy. [PDF]

Biomolecules
Shevchenko JA, Gizbrekht AA, Sennikov SV.   +2 more
europepmc   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, Volume 13, Issue 19, 2 April 2026.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

<i>Toxoplasma</i> effector GRA15-driven CCL5 secretion enhances brain parasite load through microvascular sequestration of phagocytes. [PDF]

mBio
Afanaseva E, Rodriguez ME, Barragan A.
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Plasma proteins and rheumatoid arthritis: A Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Lu C, Huang XX, Lu X, Huang M, Xu J.
europepmc   +1 more source

Peripheral lncRNA–IL1RAP Dysregulation in Schizophrenia: A Multi‐Omics Bridge Between Immunity and Diagnosis

Brain and Behavior, Volume 16, Issue 4, April 2026.
Bulk RNA‐seq of PBL from first‐episode or unmedicated SCZ patients identifies an opposite‐direction two‐lncRNA signal at the CCR3 and IL1RAP loci, supported by qRT–PCR and yielding strong internal but uncertain external discrimination. Immune‐linked programs recurrently involve IL1RAP/IL‐1 branches and map, in a healthy‐donor PBMC single‐cell reference,
Jie Wu, Ruize Niu, Zijun Liu, Yuanyuan Li, Yunqiao Zhang, Zhaowei Teng, Yong Zeng, Tianhao Bao   +7 more
wiley   +1 more source

A new type of biomarker for heat stress: insights from immunology. [PDF]

Front Immunol
Ye C, Zhang Z, Yang Z.
europepmc   +1 more source