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Chemotaxis of polymorphonuclear leukocytes
Biochemical Pharmacology, 1968Abstract Chemotaxis of polymorphonuclear leukocytes (PMN) has been studied by the use of chambers with micropore filters. This technique measures the specific, unidirectional migration of PMN toward an attractant. The nature of the medium in which the cells are suspended is important because homologous serum considerably increases cell responsiveness
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Polymorphonuclear leukocyte chemotaxis in sporotrichosis
Mycopathologia, 1982A lesion of sporotrichosis shows a characteristic arrangement of the infiltrate in three zones: the central suppurative zone composed of polymorphonuclear leukocytes, the tuberculoid zone and the round cell zone. For investigating the pathomechanism of the suppurative zone formation, polymorphonuclear leukocyte chemotaxis to sporotrichin was assayed ...
H, Hachisuka +3 more
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Assays of leukocyte locomotion and chemotaxis
Journal of Immunological Methods, 1998This review discusses the range of methods which are currently available for measuring locomotion and chemotaxis of leukocytes in vitro, their history, and some definitions of terms. Assays of the net migration of large cell populations, such as the filter assay are the most popular and are useful for identifying chemoattractant molecules, but give no ...
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Methods for Quantitation of Leukocyte Chemotaxis and Fugetaxis
2010Chemoattraction and chemorepulsion are complex directional responses of a cell to external chemotactic stimuli. The decision of a cell to move towards or away from a chemokinetic source includes detection and quantitation of the gradient of the chemotactic agent, biochemical transmission of the stimulus, and translation into a directional migration ...
VIANELLO, FABRIZIO +2 more
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Roles of PI3Ks in leukocyte chemotaxis and phagocytosis
Current Opinion in Cell Biology, 2002Through selective disruption of phosphoinositide 3-kinase (PI3K) activity and the use of green fluorescent protein tagged derivatives of domains capable of specifically binding the lipid products of PI3Ks in vivo, it has been shown that this family of signalling enzymes have vital and distinct roles in chemotaxis, phagocytosis and phagosome maturation ...
Len, Stephens +2 more
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Mechanisms of leukocyte motility and chemotaxis
Current Opinion in Immunology, 1994Motility is a complex process that depends on the coordination of many cellular functions, including the conversion of information from the environment into a series of coordinated responses that culminate in directed cell movement. Major advances have been made in the understanding of many functions involved in motility, such as transmembrane ...
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Cellular augmentation of polymorphonuclear leukocyte chemotaxis
American Journal of Physiology-Cell Physiology, 1979The density of neutrophils influences the number of cells that will respond to a chemoattractant, endotoxin-activated serium. When fewer than 3 x 10(5) polymorphonuclear leukocytes (PMN) were placed in the top compartment of a modified Boyden chemotaxis chamber, the cellular response was weak.
A, Takeuchi, R H, Persellin
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Humoral Mediators of Chemotaxis of Mononuclear Leukocytes
Journal of Infectious Diseases, 1972In-vitro studies of chemotaxis of mononuclear leukocytes (MNLs) were performed to characterize humoral mediators governing the accumulation of these cells at inflammatory sites. Two humoral factors that attract MNLs in vitro were found. The first was a heat-labile factor (mol wt, 90,000) present in untreated guinea-pig serum and plasma.
M S, Hausman +2 more
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Chemokines and chemotaxis of leukocytes in infectious meningitis
Journal of Neuroimmunology, 1998Chemokines constitute a constantly growing family of small inflammatory cytokines. They have been implied in many different diseases of the CNS including trauma, stroke and inflammation, e.g., multiple sclerosis. In this review we focus on the role of chemokines in infectious meningitis of bacterial or viral origin. In experimental bacterial meningitis
Lahrtz F +4 more
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Effects of Lithium on Polymorphonuclear Leukocyte Chemotaxis
1980Lithium, known best for its efficacy in the treatment of neuropsychiatric disorders, also is capable of influencing the function of a variety of non-neural cells. Shenkman et al. (1978), for example, demonstrated that lithium was capable of enhancing several functions of human peripheral blood mononuclear cells.
H D, Perez +4 more
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