Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. [PDF]
, 2020 Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two ...
Draf, Clara +6 more
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The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury [PDF]
, 2012 Recent evidence has demonstrated additional roles for the neuronal guidance protein receptor UNC5B outside the nervous system. Given the fact that ischemia reperfusion injury (IRI) of the liver is a common source of liver dysfunction and the role of ...
Granja, Tiago +7 more
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Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]
, 1990 Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H. +3 more
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Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5
Mediators of Inflammation, 1993 Human recombinant lipocortins (LCT) 1 and 5 have been expressed in a yeast secretion vector and purified by ion exchange chromatography. The action of the proteins has been investigated in two models of experimental acute inflammation in the rat ...
C. Becherucci +4 more
doaj +1 more source
How Have Leukocyte In Vitro Chemotaxis Assays Shaped Our Ideas about Macrophage Migration?
Biology, 2020 Macrophage chemotaxis is crucial during both onset and resolution of inflammation and unique among all leukocytes. Macrophages are able to switch between amoeboid and mesenchymal migration to optimise their migration through 3D environments.
Agata N. Rumianek, David R. Greaves
doaj +1 more source
A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages. [PDF]
PLoS ONE, 2018 The leukocyte chemosensory pathway detects attractant gradients and directs cell migration to sites of inflammation, infection, tissue damage, and carcinogenesis.
Brian P Ziemba, Joseph J Falke
doaj +1 more source
In vitro and in vivo effects of salbutamol on neutrophil function in acute lung injury [PDF]
, 2006 Background: Intravenous salbutamol (albuterol) reduces lung water in patients with the acute respiratory distress syndrome (ARDS). Experimental data show that it also reduces pulmonary neutrophil accumulation or activation and inflammation in ARDS ...
McAuley, Daniel F. +4 more
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BMC Genomics, 2022 Background Disease emergence and production loss caused by cattle tick infestations have focused attention on genetic selection strategies to breed beef cattle with increased tick resistance.
Emily F. Mantilla Valdivieso +8 more
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Concepts of GPCR-controlled navigation in the immune system
, 2019 G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L +26 more
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Inhibition of tumor necrosis factor α–stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase [PDF]
, 2008 <b>Objective</b>— Proatherosclerotic adhesion of leukocytes to the endothelium is attenuated by NO. As AMP-activated protein kinase (AMPK) regulates endothelial NO synthesis, we investigated the modulation of adhesion to cultured human aortic
Ewart, M-A., Kohlhaas, C.F., Salt, I.P.
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