Results 21 to 30 of about 69,950 (300)

An Agent-Based Interpretation of Leukocyte Chemotaxis in Cancer-on-Chip Experiments

Mathematics, 2022
The present paper was inspired by recent developments in laboratory experiments within the framework of cancer-on-chip technology, an immune-oncology microfluidic chip aiming at studying the fundamental mechanisms of immunocompetent behavior. We focus on
Gabriella Bretti, Andrea De Gaetano
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Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis

Frontiers in Cell and Developmental Biology, 2021
The dynamic re-organization of cellular membranes in response to extracellular stimuli is fundamental to the cell physiology of myeloid and lymphoid cells of the immune system.
Fernando Montaño-Rendón, Fernando Montaño-Rendón, Sergio Grinstein, Sergio Grinstein, Sergio Grinstein, Sergio Grinstein, Glenn F. W. Walpole, Glenn F. W. Walpole   +7 more
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In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue [PDF]

, 2009
Directional migration of transmigrated leukocytes to the site of injury is a central event in the inflammatory response. Here, we present an in vivo chemotaxis assay enabling the visualization and quantitative analysis of subtype-specific directional ...
Alexander Georg Khandoga, Peter Bihari, Khandoga, Andrej, Reichel, Christoph Andreas, Rehberg, Markus, Fritz Krombach, Christoph Andreas Reichel, Markus Rehberg, Bihari, Peter, Krombach, Fritz, Khandoga, Alexander Georg, Andrej Khandoga   +11 more
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Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour [PDF]

, 2011
The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement.
Haastert, Peter J.M. van,, Peter J M van Haastert, van Haastert, Peter J. M., van Haastert, Peter J.M., Matthew P. Neilson, Douwe M Veltman, Webb, Steven D., Insall, Robert H., Webb, Steven D.,, Neilson, Matthew P.,, Neilson, Matthew P., Matthew P Neilson, Douwe M. Veltman, Peter J. M. van Haastert, Insall, Robert H.,, Steven D Webb, Webb, Steven, Robert H Insall, John A. Mackenzie, Mackenzie, John A.,, John A Mackenzie, Veltman, Douwe M.,, Mackenzie, John A., Veltmahn, Douwe M., Veltman, Douwe M., Steven D. Webb, Robert H. Insall   +26 more
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Leukocyte chemotaxis: from lysosomes to motility [PDF]

, 2010
Chemoattractants direct the extravasation of leukocytes to the site of immune response.
Gabriela Constantin, Carlo Laudanna, CONSTANTIN, Gabriela, LAUDANNA, Carlo   +3 more
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Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling [PDF]

, 2013
Background: Morus alba has long been used in traditional Chinese medicine to treat inflammatory diseases;however, the scientific basis for such usage and the mechanism of action are not well understood. This studyinvestigated the action of M.
Yin-Jing Tien, Wen-Chin Yang, Evangeline C Amor, Den-Jen Wu, Yea-Lih Lin, Francesca N Beltran, Clément Mettling, Yi-Ching Chen, Ran-Juh Wang, Chun-Houh Chen   +9 more
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P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells [PDF]

, 2014
This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release.The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and ...
Campwala, H., Fountain, Samuel J., Sexton, D. W., Campwala, Hinnah, Fountain, SJ, Crossman, David C., Sexton, Darren W., Campwala, H, Crossman, D. C., Fountain, S. J., Sexton, DW, Crossman, DC   +11 more
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Effects of the PI3K pathway on neutrophil chemotaxis and swarming [PDF]

, 2022
Neutrophils form part of the innate immune system, they are the most abundant circulating leukocytes in humans and play a crucial role in host defence and inflammation.
Michael, Melina
core   +1 more source

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]

, 2014
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
Gabriela Kalna (192504), William J. Faller (644356), Bennett, DC, Knecht, D, Veltman, DM, Jones, R, Andrew J Muinonen-Martin, Muinonen-Martin, Andrew J, Muinonen-Martin, AJ, Lindsay, C, Faller, William J., Douwe M Veltman, Wakelam, Michael J.O., Dorothy C Bennett, David A Knecht, Owen J Sansom, Zhang, Qifeng, Faller, WJ, Michael J O Wakelam, Machesky, Laura M, Bennett, Dorothy C., Knecht, David A, Robert Jones (270787), Gabriela Kalna, Knecht, DA, Insall, Robert H, Machesky, Laura M., Smethurst, Elizabeth, Smethurst, E, Lindsay, Colin; id_orcid, Robert Jones, Lindsay, Colin, Insall, RH, Sansom, Owen J., Elizabeth Smethurst (644355), Faller, William J, Jones, Robert, Laura M Machesky, Knecht, David A., Robert H. Insall (220984), Sansom, Owen J, Andrew J. Muinonen-Martin (235328), Michael J. O. Wakelam (116384), Sansom, OJ, Machesky, LM, Machesky, Laura, Wakelam, Michael J O, Robert Herd, Insall, Robert H., Owen J. Sansom (192366), Douwe M. Veltman (220981), Veltman, Douwe M, Wakelam, MJ, Kalna, Gabriela, Elizabeth Smethurst, Muinonen-Martin, Andrew J., Susanto, Olivia, William J Faller, Colin Lindsay, Herd, R, Zhang, Q, Susanto, O, Robert H Insall, Qifeng Zhang (116382), Laura M. Machesky (175567), Bennett, Dorothy C, Kalna, G, Robert Herd (644358), Olivia Susanto (644354), Colin Lindsay (644357), Qifeng Zhang, Herd, Robert, Dorothy C. Bennett (234520), David A. Knecht (231111), Olivia Susanto, Veltman, Douwe M., Bennett, Dorothy   +76 more
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Targeting Chemokine—Glycosaminoglycan Interactions to Inhibit Inflammation

Frontiers in Immunology, 2020
Leukocyte migration into tissues depends on the activity of chemokines that form concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with their specific G protein-coupled receptors (GPCRs) on leukocytes induces ...
Helena Crijns, Vincent Vanheule, Paul Proost   +2 more
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