Results 71 to 80 of about 99,840 (283)

Polymorphonuclear leukocyte chemotaxis in dermatitis herpetiformis

Acta Dermato-Venereologica, 1981
Polymorphonuclear leukocyte chemotaxis was investigated in 15 patients with dermatitis herpetiformis and was found not to be significantly increased when compared with the polymorphonuclear leukocyte chemotaxis of 15 normal healthy controls. These results indicate that accumulations of polymorphonuclear leukocytes found in the skin of patients with ...
S A, Esca, H, Pehamberger, W, Silny, K, Holubar   +3 more
openaire   +2 more sources

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour [PDF]

, 2011
The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement.
A Cvejic, A Millius, A Mogilner, A Narang, A. P Wheeler, B Varnum-Finney, C Arrieumerlou, C Janetopoulos, C. I Lacayo, C. P McCann, Douwe M. Veltman, G Dziuk, G Gerisch, H Levine, H Meinhardt, H. R Bourne, I. M Mitchell, J Satulovsky, J. A Swanson, John A. Mackenzie, K Keren, K. F Swaney, L Bosgraaf, L Bosgraaf, L Chen, L Li, L Ma, M Enculescu, M. A Lokuta, M. P Neilson, Matthew P. Neilson, N Andrew, O Brandman, O Hoeller, O. D Weiner, O. D Weiner, P Devreotes, P. A Iglesias, P. J Van Haastert, Peter J. M. van Haastert, R. H Insall, R. H Insall, R. H Insall, R. T Tranquillo, Robert H. Insall, S Osher, S Srinivasan, Steven D. Webb, T Inoue, T Killich, T Killich, Thomas Pollard, X Zheng   +52 more
core   +8 more sources

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

As quimiocinas e os seus receptores: características e funções fisiológicas.

Acta Médica Portuguesa, 2011
Chemokines are members of a large family of small soluble proteins, which were discovered by their adhesion control, chemotaxis and leukocyte activation abilities.
Rita Guerreiro, Quirina Santos-Costa, J M Azevedo-Pereira   +2 more
doaj   +1 more source

Leukocyte chemotaxis.

Allergologia et immunopathologia, 1989
Monocyte chemotaxis is a function of mononuclear phagocytic system cells that enables migration toward the focus of infection and inhibition of microorganism growth and proliferation. In this paper we review the chemotactic phenomena following Becker's scheme that distinguishes three phases: recognition, transduction and the effector phase.
J L, Pérez Castrillón, J D, García Palomo, J L, Pérez Arellano, A, Jíménez López   +3 more
openaire   +1 more source

Iron/Cobalt Dual‐Atom Catalyst Orchestrate Photothermal‐Chemodynamic Immunotherapy Against MRSA: Multi‐Omics Dissection in Murine and Porcine Models

Advanced Science, EarlyView.
FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu, Binge Huang, Hao Lin, Jinming Li, Zhaoxiang Lu, Qi Zhang, Jia Li, Shiping Yang, Songsong Lan, Yan Yang, Yun Feng, Xiaojun He   +11 more
wiley   +1 more source

Potential molecular communication of blood and synovium through ligand-receptor interactions in osteoarthritis

Frontiers in Medicine
IntroductionOsteoarthritis (OA) is a common degenerative joint disease resulting from the breakdown of multiple joint tissues, remains a leading cause of disability with limited therapeutic options.
Maochun Wang, Guihua Tan, Shiqi Wang, Wenxue Lv   +3 more
doaj   +1 more source

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, EarlyView.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

Advanced Science
To move forward, cells must exert backward forces against their surrounding environment. Recent studies have highlighted the importance of integrin‐independent forces for cell migration; however, the molecular machinery that exerts forces remains unclear.
Kentarou Baba, Ami Fukushi‐Kumagai, Megumi Morisaki, Ryosuke Takeuchi, Zhize Xiao, Yoshikazu Nagashima, Mizuki Sakai, Yasuna Higashiguchi, Hiroko Katsuno‐Kambe, Asako Katsuma, Yoshihiro Ueda, Yuji Kamioka, Daisuke Kawauchi, Tatsuo Kinashi, Yonehiro Kanemura, Naoyuki Inagaki   +15 more
doaj   +1 more source