Results 171 to 180 of about 277,155 (334)

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

MOF Coating Enhances the Ion Tolerance of Micromotors

Angewandte Chemie, EarlyView.
This work reported a novel method to significantly enhance the ion tolerance of EMNMs using a MOF coating via controllable heteroepitaxial growth, enabling effective motion in high‐salt environments and propulsion through biological tissues under 980 nm NIR light, with potential applications in targeted drug delivery.
Leyan Ou, Kunfeng Liu, Yifan Zhang, Wanyuan Li, Zixian Liang, Dapeng Lei, Hao Sun, Mojun Chen, Jizhuang Wang, Jinyao Tang, Dan Li   +10 more
wiley   +2 more sources

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Advancements in Machine Learning for Microrobotics in Biomedicine

Advanced Intelligent Systems, EarlyView.
Microrobotics is an innovative technology with great potential for noninvasive medical interventions. However, controlling and imaging microrobots pose significant challenges in complex environments and in living organisms. This review explores how machine learning algorithms can address these issues, offering solutions for adaptive motion control and ...
Amar Salehi, Soleiman Hosseinpour, Nasrollah Tabatabaei, Mahmoud Soltani Firouz, Niloufar Zadebana, Richard Nauber, Mariana Medina‐Sánchez   +6 more
wiley   +1 more source

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

EMBO Reports, 2017
F. Mazaheri, Nicolas Snaidero, G. Kleinberger, C. Madore, A. Daria, G. Werner, S. Krasemann, A. Capell, D. Trümbach, W. Wurst, B. Brunner, Sebastian Bultmann, S. Tahirovic, M. Kerschensteiner, T. Misgeld, O. Butovsky, C. Haass   +16 more
semanticscholar   +1 more source

Biomimetic Chemotactic Motion of Self‐Assembling Doublet Microrobots

Advanced Intelligent Systems, EarlyView.
This article studies the shape‐dependent chemotaxis of different morphologies including self‐assembled doublet microswimmers that exhibit autonomous movement in hydrogen peroxide H2O2 gradients. Without the need for complex material preparation a novel type of chemotactic active matter is produced, which allows the separation of propulsion and cargo ...
Zuyao Xiao, Maximilian Voigtmann, Juliane Simmchen   +2 more
wiley   +1 more source

Relationship between haptotaxis and chemotaxis in cell dynamics [PDF]

arXiv
The phenomenon where cells with elongated protrusions, such as neurons, communicate by contacting other cells and arrange themselves appropriately is termed cell sorting through haptotaxis. This phenomenon is described by partial differential equations involving nonlocal advection.
arxiv  

Comparative analysis of short‐term and long‐term LL‐37‐induced rosacea‐like mouse models: Histopathological features and inflammatory immune responses

Animal Models and Experimental Medicine, EarlyView.
The aim of this study was to improve the long‐term LL‐37 mouse model and compare the disease manifestations and pathophysiology of short‐term and long‐term LL‐37‐induced rosacea‐like models. The results show that the long‐term LL‐37 induced mouse model provides a practical animal model for further study of the pathological mechanism of severe rosacea ...
Yiling Wu, Chuanxi Zhang, Hui Jin, Ruiping Zheng, Tian Li, Fuyu Jin, Yaqian Li, Xuemin Gao, Hong Xu, Zhongqiu Wei, Jie Yang   +10 more
wiley   +1 more source