Results 241 to 250 of about 277,006 (294)

Potential Effects of Three Forms of Sialic Acid on Intestinal Health in Obese Mice Fed With a High‐Fat Diet

Food Frontiers, EarlyView.
A high‐fat diet impairs intestinal health by disrupting the mucus layer, widening epithelial gaps, triggering inflammation, and causing microbial dysbiosis, ultimately leading to obesity and metabolic disorders. Sialic acid interventionsparticularly bound forms (3ʹ‐SL and EBN)outperform free Neu5Ac in restoring microbial balance, alleviating ...
Xinyue Wang, Wei Zhang, Xinyuan Huang, Linlin Zhou, Xinning Zhao, Hanying Zheng, Xudan Shen, Xinyi Wang, Lili Pan, Yahui Li, Hongwei Li   +10 more
wiley   +1 more source

hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells

Glia, EarlyView.
SCZ astrocytes display an increased pro‐inflammatory profile upon TNF‐α stimulation. Reactive SCZ astrocytes induce microglial‐like cells to assume a dystrophic phenotype. Reactive SCZ astrocytes limit iMGs' synaptoneurosome uptake and migration. ABSTRACT Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ)
Pablo L. Cardozo, Chia‐Yi Lee, Juliana P. S. Lacerda, Júlia S. Fahel, Pablo Trindade, Gabriela Vitória, Leonardo Chicaybam, Rafaela C. Cordeiro, Isaque J. S. de Faria, Nathália C. Silva, Yaovi M. H. Todjro, Joana C. do P. Maciel, Martin H. Bonamino, Luciene B. Vieira, Breno F. Cruz, Rodrigo Nicolato, Kristen J. Brennand, Stevens K. Rehen, Fabíola M. Ribeiro   +18 more
wiley   +1 more source

Chemotactic navigation in robotic swimmers via reset-free hierarchical reinforcement learning. [PDF]

Nat Commun
Xiong T, Liu Z, Wang Y, Ong CJ, Zhu L.
europepmc   +1 more source

Reduced insulin-like signaling restores motor and chemosensory neuron function in <i>C. elegans</i> expressing TDP-43, an ALS-associated protein. [PDF]

MicroPubl Biol
Lotesto V, Voisine C.
europepmc   +1 more source

Surgical site infections and sepsis in gynecological surgery

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Despite advancements in infection control, surgical site infections (SSIs) and postoperative sepsis remain significant challenges in gynecological surgery, contributing to increased morbidity, mortality, and healthcare costs. In low‐income countries, circulatory failure due to septic shock leads to most deaths after surgery, with sepsis ...
Cristina Taliento, Gennaro Scutiero, Carmelia Milano, Mattia Grasso, Francesca Nitti, Orsola Brasile, Ruby Martinello, Giulia Bernardi, Stefano Restaino, Martina Arcieri, Matteo Pavone, Nicolò Bizzarri, Giuseppe Vizzielli, Pantaleo Greco   +13 more
wiley   +1 more source

Hanging drop culture reprograms mesenchymal stem cell transcriptome to enhance cell delivery efficiency via attenuated pulmonary entrapment. [PDF]

Drug Deliv Transl Res
Lee HT, Fu SY, Weng WH, Chao WC, Hsu YP, Yang NP, Chen YH, Chen SK, Chang CW.   +8 more
europepmc   +1 more source

A Phase 1 Randomized Study: Garadacimab Pharmacokinetics, Safety, and Tolerability After Administration via Autoinjector/Pre‐Filled Pen Versus Pre‐Filled Syringe in Healthy Participants

The Journal of Clinical Pharmacology, EarlyView.
Abstract Garadacimab is a novel, fully human, anti‐activated factor XII monoclonal antibody approved for long‐term prophylaxis of patients with hereditary angioedema. This open‐label, parallel‐group, Phase 1, single‐center, bridging study in healthy adults (18–55 years of age) characterized the pharmacokinetics and safety of a single 200 mg ...
Fiona Glassman, John‐Philip Lawo, Mihai Alexandru Bica, Anthony Roberts, David Kormann, Ligia Chialda, Soeren Miethke, Iwona Dziadowiec, Stephen Caltabiano, Thomas Puchalski   +9 more
wiley   +1 more source

Influence of Acute Phase Proteins on Neutrophil Function In Vitro. [PDF]

FASEB Bioadv
Kraus RF, Wild I, Gruber MA, Kees MG.
europepmc   +1 more source