Results 241 to 250 of about 277,155 (334)

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Neutrophils at the Crossroads of Inflammatory Bowel Disease and Atherosclerosis: A State-of-the-Art Review. [PDF]

Cells
Genkel V, Zaripova Y, Kuznetsova A, Sluchanko A, Minasova A, Zotova M, Saenko A, Savochkina A, Dolgushina A.   +8 more
europepmc   +1 more source

Nanomaterials for promoting axon regeneration after spinal cord injury: Mechanisms and prospects

Interdisciplinary Medicine, EarlyView.
The effects of clinical therapies for spinal cord injury (SCI) are greatly limited due to poor axon regeneration. This review systematically discusses the ability of nanomaterials (NMs) to treat SCI and the mechanism underlying their therapeutic effects. The properties of NMs that are conducive to axon regeneration after SCI are outlined.
Jia Liu, Zhendong Huang, Xiner Tan, Wei Du, Ziyang Wang, Xinru Zhou, Hao Pan, Lili Chen, Yiyuan Kang, Longquan Shao   +9 more
wiley   +1 more source

Argentine ant chemical profiles vary by location on the Stanford University campus. [PDF]

MicroPubl Biol
Nangia A, Gonzalez M, O'Connell LA, Fiocca K.   +3 more
europepmc   +1 more source

Role of Macrophage TLR4 Expression in the Immunopathogenesis of Severe Aplastic Anemia

Journal of Clinical Laboratory Analysis, EarlyView.
This study found that the high expression of TLR4 in macrophages of SAA patients was positively correlated with the sepsis level, and inhibition of TLR4 expression could reduce the macrophage sepsis level and the killing effect of CD8+ T cells, thus alleviating the over‐activated cellular immune response in SAA patients.
Mengran Gao, Xiaorui Meng, Yi Cui, Ling Deng, Xinrui Zhang, Chunyan Liu, Rong Fu   +6 more
wiley   +1 more source

Tumor suppressing function of SLC16A7 in bladder cancer and its pan-cancer analysis. [PDF]

BMC Cancer
Xu M, Zhou J, Lv J, Zhang Y.
europepmc   +1 more source

Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development

Med Research, EarlyView.
Mutual shaping of tumor microbiota and TME. Intratumoral microbiota—comprising diverse bacteria, fungi, viruses, and intracellular organisms—play critical and dynamic roles in shaping the tumor microenvironment (TME). Their spatial and compositional diversity contributes to both intratumoral and intertumoral heterogeneity, influencing immune modulation
Zhifei Gao, Aimin Jiang, Zizhuo Li, Lingxuan Zhu, Weiming Mou, Weitao Shen, Peng Luo, Bufu Tang, Jian Zhang, Anqi Lin   +9 more
wiley   +1 more source

Falsifying computational models of endothelial cell network formation through quantitative comparison with in vitro models. [PDF]

PLoS Comput Biol
Vergroesen TM, Vermeulen V, Merks RMH.
europepmc   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

An atlas of metabolites driving chemotaxis in prokaryotes. [PDF]

Nat Commun
Brunet M, Amin SA, Bodachivskyi I, Kuzhiumparambil U, Seymour JR, Raina JB.   +5 more
europepmc   +1 more source