Results 111 to 120 of about 800,324 (296)

Impact of adjuvant chemotherapy delay on overall survival in early-stage breast cancer: a retrospective analysis

Frontiers in Oncology
BackgroundIn Early-Stage Breast Cancer (EBC), there is no clear consensus on the ideal window for initiation of adjuvant chemotherapy from the time of definitive surgery.
Ahmad Alhalabi, Theresa Abdo, María Herrán, Kaylee Sarna, Rami Tfayli, Zeina Nahleh   +5 more
doaj   +1 more source

Efficacy variations of adjuvant chemotherapy across disease stages in duodenal adenocarcinoma: a multivariate survival analysis based on the SEER database [PDF]

Waike lilun yu shijian
Objective To investigate the efficacy of adjuvant chemotherapy for patients with duodenal adenocarcinoma (DAC) at different stages. Methods A retrospective analysis was performed on patients diagnosed with DAC between January 2000 and December 2021 using
WANG Yu, HU Kaixin, ZHAO Fengqing, LI Huangbao
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Survival benefits of postoperative adjuvant chemotherapy in adults aged ≥ 80 years with locally advanced gastric cancer: insights from a population-based study

Discover Oncology
Background and aims Postoperative adjuvant chemotherapy in older adults aged ≥ 80 years with locally advanced gastric cancer (LAGC) remains debated owing to concerns over treatment tolerance and limited data.
Fuhai Ma, Yangyang Zheng, Jian Cui, Zijian Li, Jinxin Shi, Tianming Ma, Xianglong Cao, Tao Yu, Guoju Wu, Gang Zhao, Jinghai Song, Qi An   +11 more
doaj   +1 more source

Impact of timing of adjuvant chemotherapy on survival for early-stage node-negative small-cell lung cancerCentral MessagePerspective

JTCVS Open
Background: The relationship between timing of adjuvant chemotherapy and survival for early-stage, node-negative small cell lung cancer is not well defined, and no formal guidelines exist. We sought to evaluate whether increasing the time between surgery
Arian Mansur, MD, Adele J. Lee, BA, Alexandra L. Potter, BS, Jacob M. Sands, MD, Catherine B. Meador, MD, PhD, Michael Lanuti, MD, Chi-Fu Jeffrey Yang, MD   +6 more
doaj   +1 more source

Colorectal cancer. A novel approach to adjuvant chemotherapy with fluoropyrimidines.

, 2002
Adjuvant chemotherapy of colorectal cancer is ...
CONTE, PIERFRANCO, Bonino F
core   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Kaplan–Meier analysis of patients who received anthracycline-based adjuvant chemotherapy versus non-anthracycline-based adjuvant chemotherapy.

, 2016
(A) Recurrence-free survival (RFS) of BRCAness tumors (n = 126). (B) Overall survival (OS) of BRCAness tumors (n = 126). (C) RFS of non-BRCAness tumors (n = 53). (D) OS of non-BRCAness tumors (n = 53).
Tomofumi Osako (770948), Masaya Kai (3564953), Nobuyuki Arima (770954), Junji Kishimoto (647153), Masayuki Okido (3564947), Reiki Nishimura (770947), Mai Yamada (3564950), Tetsuyuki Miyazaki (3564941), Makoto Kubo (341120), Yasuhiro Okumura (770950), Masafumi Nakamura (2368807), Hitomi Mori (3564944), Yoshinao Oda (629764), Takao Otsuka (759488)   +13 more
core   +1 more source