Results 121 to 130 of about 747,376 (295)

Impact of adjuvant chemotherapy delay on overall survival in early-stage breast cancer: a retrospective analysis

Frontiers in Oncology
BackgroundIn Early-Stage Breast Cancer (EBC), there is no clear consensus on the ideal window for initiation of adjuvant chemotherapy from the time of definitive surgery.
Ahmad Alhalabi, Theresa Abdo, María Herrán, Kaylee Sarna, Rami Tfayli, Zeina Nahleh   +5 more
doaj   +1 more source

An integrated model of the transcriptome of HER2-positive breast cancer [PDF]

, 2013
Our goal in these analyses was to use genomic features from a test set of primary breast tumors to build an integrated transcriptome landscape model that makes relevant hypothetical predictions about the biological and/or clinical behavior of HER2 ...
Melissa Lau, High-seng Chai, David Rossell, Brian M. Necela (224867), Jeanette E. Eckel-Passow (228909), S. Keith Anderson (271824), Tang, Xiaojia, Rossell, David, Kevin J. Thompson (479037), E. Aubrey Thompson (224877), Sarah A McLaughlin, Baker, Tiffany R., Kalari, Krishna R., Necela, Brian M., Xiaojia Tang, Melissa Lau (479038), David Rossell (479046), Lau, Melissa, Derek C Radisky, Krishna R. Kalari (228899), Richard W. Joseph (479042), Sarah A. McLaughlin (479043), Camille, Stephan, Thompson, E. Aubrey, McLaughlin, Sarah A., S Keith Anderson, Saurabh Baheti, Tiffany R Baker, Jennifer M Kachergus, Jennifer M Carr, Joseph, Richard W., Asmann, Yan W., Kachergus, Jennifer M., Yan W. Asmann (210163), Zhifu Sun (60356), Derek C. Radisky (119628), Carr, Jennifer M., Richard W Joseph, Krishna R Kalari, Jennifer M. Carr (224872), Thompson, Kevin J., High-seng Chai (479044), Stephan Camille (479045), Kevin J Thompson, Poulami Barman (479041), Poulami Barman, Edith A Perez, Xiaojia Tang (53518), Saurabh Baheti (479040), Anderson, S. Keith, Barman, Poulami, Brian M Necela, Stephan Camille, Radisky, Derek C., Jennifer M. Kachergus (479039), Eckel-Passow, Jeanette E., Chai, High-seng, Perez, Edith A., Sun, Zhifu, E Aubrey Thompson, Yan W Asmann, Tiffany R. Baker (228915), Zhifu Sun, Baheti, Saurabh, Edith A. Perez (228921), Jeanette E Eckel-Passow   +65 more
core   +1 more source

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

Advanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang, Shibo Zhao, Wenying Wu, Zhiwei Duan, Yuan Li, Xiangyu Zeng, Liang Hong, Yan Chen, Ling Tao, Kewu Zeng, Chaoda Xiao, Xiangchun Shen   +11 more
wiley   +1 more source

Clinical response after two cycles compared to HER2, Ki-67, p53, and bcl-2 in independently predicting a pathological complete response after preoperative chemotherapy in patients with operable carcinoma of the breast [PDF]

, 2008
Introduction To investigate the predictive value of clinical and biological markers for a pathological complete remission after a preoperative dose-dense regimen of doxorubicin and docetaxel, with or without tamoxifen, in primary operable breast cancer ...
Sinn, Hans-Peter, Sibylle Loibl, Jens-Uwe Blohmer, Jörn Hilfrich, Eidtmann, Holger, Jackisch, Christian, Minckwitz, Gunter von, Elisabeth Merkle, Hilfrich, Jörn, Caputo, Angelika, Angelika Caputo, Merkle, Elisabeth, Dan Costa, Serban, Blohmer, Jens-Uwe, Gunter von Minckwitz, Raab, Günter, German Breast Group (GBG), [Study group], Christian Jackisch, Hans-Peter Sinn, Serban D Costa, Holger Eidtmann, Loibl, Sibylle, Manfred Kaufmann, von Minckwitz, Gunter, null null, Günter Raab, Costa, Serban D., Kaufmann, Manfred   +27 more
core   +2 more sources

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Survival benefits of postoperative adjuvant chemotherapy in adults aged ≥ 80 years with locally advanced gastric cancer: insights from a population-based study

Discover Oncology
Background and aims Postoperative adjuvant chemotherapy in older adults aged ≥ 80 years with locally advanced gastric cancer (LAGC) remains debated owing to concerns over treatment tolerance and limited data.
Fuhai Ma, Yangyang Zheng, Jian Cui, Zijian Li, Jinxin Shi, Tianming Ma, Xianglong Cao, Tao Yu, Guoju Wu, Gang Zhao, Jinghai Song, Qi An   +11 more
doaj   +1 more source

Efeito da quimioterapia sobre o peso corporal e o estresse oxidativo em mulheres com câncer de mama [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Florianópolis, 2011O tratamento quimioterápico para o câncer de mama tem sido associado a diferentes efeitos, entre eles ...
Galvan, Daisy
core  

Effects of neo-adjuvant chemotherapy for oesophago-gastric cancer on neuro-muscular gastric function [PDF]

, 2012
Delayed gastric emptying symptoms are often reported after chemotherapy. This study aims to characterise the effects of chemotherapy on gastric neuro-muscular function.
Arasaradnam, Ramesh P., Jarvie, E. M., Goodyear, S. J., Borman, R. A., Snead, David R. J., Sanger, G. J., Nwokolo, Chuka U., James, Sean G., Sung, E. Z. H.   +8 more
core   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Neoadjuvant chemotherapy is not necessarily applicable to patients with LN1-3 positive Luminal-B type operable breast cancer

Scientific Reports
The purpose of is to identify the necessity of neoadjuvant chemotherapy in luminal type breast cancer patients (HR-positive HER2-negative) by exploring the treatment characteristics, treatment plan, surgical choice and long-term prognosis between ...
Tiantian Tang, Cong Wang, Xin Lv, Zhigang Fan, Hanxiao Ren, Yuntao Li   +5 more
doaj   +1 more source