Results 31 to 40 of about 3,981,458 (213)

Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin

Pharmacological Research, 2022
Thrombocytopenia, a most common complication of radiotherapy and chemotherapy, is an important cause of morbidity and mortality in cancer patients. However, there are still no approved agents for the treatment of radiation- and chemotherapy-induced ...
Long Wang, Ting Zhang, Sha Liu, Qi Mo, Nan Jiang, Qi Chen, Jing Yang, Yun-Wei Han, Jian-Ping Chen, Fei-Hong Huang, Hua Li, Jie Zhou, Jie-Si Luo, Jian-Ming Wu   +13 more
doaj   +1 more source

Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature [PDF]

, 2021
Thrombocytopenia may be associated with a variety of conditions and risks depending on its severity, ranging from mild epistaxis to life-threating bleeding. Many drugs or herbal remedies can cause thrombocytopenia by either inhibiting platelet production
Eleftheria Hatzimichael, Anastasia Serpanou, Eleni Kapsali, Konstantina Papathanasiou, Ioannis Papakonstantinou, Epameinondas Koumpis, Iliana Tassi   +6 more
core   +1 more source

Observation on the efficacy of TPO receptor agonists and platelet transfusion in chemotherapy-induced thrombocytopenia in malignant tumors. [PDF]

World J Surg Oncol
Objective To observe the clinical efficacy of TPO receptor agonists and platelet transfusion in chemotherapy-induced thrombocytopenia in malignant tumors.
Hu H, Lei D, Liang Y.
europepmc   +2 more sources

Fibrinolysis in patients with chemotherapy‐induced thrombocytopenia and the effect of platelet transfusion [PDF]

Journal of Thrombosis and Haemostasis, 2019
Essentials Bleeding in chemotherapy induced thrombocytopenia (CIT) might be influenced by hyperfibrinolysis. t-PA-thromboelastography is a fast and reliable assay for hyperfibrinolysis in CIT patients. Clots of CIT patients are more susceptible to t-PA induced lysis compared to healthy individuals.
Heubel-Moenen, Floor C. J. I., Henskens, Yvonne M. C., Verhezen, Paul W. M., Wetzels, Rick J. H., Schouten, Harry C., Beckers, Erik A. M.   +5 more
openaire   +2 more sources

Thrombocytopenia limits the feasibility of salvage lomustine chemotherapy in recurrent glioblastoma: a secondary analysis of EORTC 26101 [PDF]

, 2022
Background: Thrombocytopenia represents the main cause of stopping alkylating chemotherapy for toxicity. Here, we explored the incidence, and the consequences for treatment exposure and survival, of thrombocytopenia induced by lomustine in recurrent ...
Brandes, Alba A., Clement, Paul M., Le Rhun, Emilie, Idbaih, Ahmed, Golfinopoulos, Vassilis, Clement, Paul M, Platten, Michael, Weller, Michael, Gorlia, Thierry, Wick, Wolfgang, Oppong, Felix Boakye, Brandes, Alba A, van den Bent, Martin, van den Bent, Martin; id_orcid, Taphoorn, Martin J.B., Preusser, Matthias, Rhun, E. le, Oppong, F.B., Bent, M. van den, Idbaih, A., Wick, W., Weller, M., Platten, M., Golfinopoulos, V., Clement, P.M., Gorlia, T., Brandes, A.A., Preusser, M., Taphoorn, M.J.B., Taphoorn, Martin Jb   +29 more
core   +3 more sources

sj-pdf-1-opp-10.1177_10781552231219003 - Supplemental material for Role of thrombopoietin receptor agonists in chemotherapy-induced thrombocytopenia: A meta-analysis

, 2023
Supplemental material, sj-pdf-1-opp-10.1177_10781552231219003 for Role of thrombopoietin receptor agonists in chemotherapy-induced thrombocytopenia: A meta-analysis by Gerard Gurumurthy, Filip Kisiel, Samantha Gurumurthy and Juditha Gurumurthy in Journal
Filip Kisiel (17711543), Gerard Gurumurthy (17711540), Juditha Gurumurthy (17711549), Samantha Gurumurthy (17711546)   +3 more
core   +1 more source

Chemotherapy induced thrombocytopenia treated by four types of platelets concentrates [PDF]

Hospital Pharmacology, 2015
Introduction: Serious adverse event of anticancer chemotherapy is glanulocytopenia and thrombocytopenia which can decrease efficiency of final therapy results. After many years, platelet concentrates transfusion (PCT) is still researching problem without
Nikolić Ljubinka I., Nedeljković Ninoslav D., Jelić Svetislav B., Suvajdžić Vuković Nada D., Fillipović-Lješković Ivana M., Marković Srđan Z., Janković Drina Lj., Kastratović Dragana A.   +7 more
doaj   +1 more source

Eltrombopag to allow chemotherapy in a patient with MYH9-related inherited thrombocytopenia and pancreatic cancer

, 2020
Chemotherapy is the mainstay of treatment for advanced pancreatic cancer however, due to possible myelotoxicity, it is used with caution in patients with thrombocytopenia, especially when severe.
Bury, Loredana, Paciullo, Francesco, Gresele, Paolo, Bury L, Gresele P, Paciullo F   +5 more
core   +1 more source

Prevalence and aetiology of moderate and severe thrombocytopenia in a tertiary and quaternary centre in KwaZulu-Natal

African Journal of Laboratory Medicine, 2020
Background: Thrombocytopenia is a common haematological disorder, characterised by platelet counts below 150 × 109/L. The aetiology of thrombocytopenia is multifactorial; notably, in a misdiagnosis this condition may be due to pre-analytical laboratory ...
Ayanda G. Jali, Bongani B. Nkambule
doaj   +1 more source

A Case of Recurrent Ovarian Cancer and Therapy-Related Acute Myeloid Leukemia Treated with Azacitidine

Case Reports in Oncology, 2021
Therapy-related myelodysplastic syndrome (tMDS) and acute myeloid leukemia (tAML) are lethal complications of chemotherapy. The incidence rates are expected to increase owing to improvements of cancer treatment.
Kenju Ando, Akihiko Shimomura, Ryo Nasu, Misao Nakanishi, Yukino Kawamura, Akira Hangaishi, Hajime Oishi, Chikako Shimizu   +7 more
doaj   +1 more source