Results 101 to 110 of about 1,486,273 (317)

Influence of First-Line Chemotherapy and Egfr Mutations on Second-Line Gefitinib in Advanced Non-Small Cell Lung Cancer

, 2011
Purpose. Gefitinib is a valid second-line therapy for previously treated non-small cell lung cancer (NSCLC) patients. The influences of various chemotherapy regimens and EGFR mutations on effectiveness of second-line gefitinib are not clear, and ...
WU, JENN-YU;YU, CHONG-JEN;SHIH, JIN-YUAN;YANG, CHIH-HSIN;YANG, PAN-CHYR, 巫震宇;余忠仁;施金元;楊志新;楊泮池   +1 more
core   +1 more source

CHEMOTHERAPY AND TUMORS [PDF]

Journal of the American Medical Association, 1915
Within the last three years a number of reports have appeared in the medical press which bear on the treatment of malignant growths in human beings by chemical preparations. The most persuasive and the most insistent claims have been made in connection with the colloidal solutions of certain metalloids and metals, notably selenium, vanadium and copper.
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Pseudomonas aeruginosa: the history of one of the most successful nosocomial pathogens in Russian hospitals [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2018
Pseudomonas aeruginosa is recognized as one of the six most important pathogens in terms of antimicrobial resistance («ESKAPE» pathogens), and included by WHO in the group of microorganisms for which the need for development of new antimicrobial agents ...
Skleenova E.Yu., Azyzov I.S., Shek E.A., Edelstein M.V., Kozlov R.S., Dekhnich A.V.   +5 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Helping patients discuss CINV management : development of a patient charter [PDF]

, 2013
In April 2012, an Expert Group of specialist cancer nurses working in a variety of settings (e.g. chemotherapy delivery, chemotherapy service design, research, nurse leadership and patient information/advocacy) participated in telephone/web-based ...
Dielenseger, Pascale, O’Donovan, Eileen, Jones, Philippa, Lennan, Elaine, Sharp, Sue, Whiteford, Alison, Fernandez Ortega, Paz, Fernandez Perez, Dolores, Young, Annie M., Wiles, Lilian, Fernández Pérez, María Dolores   +10 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epidemiological characteristic of Streptococcus pneumoniae serotypes from patients with invasive pneumococcal disease in the Russian Federation [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. To characterize spectrum of S. pneumoniae serotypes isolated from patients with invasive pneumococcal infection in the Russian Federation. Materials and Methods. The serotype identification of 93 S.
Muravyev A.A., Chagaryan A.N., Ivanchik N.V., Mironov K.O., Gaponova I.I., Kozlov R.S.   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Cisplatin, Etoposide, and Vincristine Combination Chemotherapy in the Treatment of Non-Small Cell Lung Cancer [PDF]

, 1993
1993-03Thirty patients with previously untreated, inoperable non-small cell lung cancer (NSCLC) were treated with cisplatin, etoposide and vincristine.
NAGURA, EIICHI, SHIMOKATA, KAORU, SAITO, HIROSHI, WATANABE, ATSUSHI, ICHIYAMA, SATOSHI, NOMURA, FUMIO, SAKAI, SHUZO, SAKA, HIDEO, SAITO, HIDEHIKO   +8 more
core   +1 more source