Results 101 to 110 of about 9,484 (238)
Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery
Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.Non‐orthosteric, low‐affinity ligands for integrin αVβ3, identified by fragment screening, achieve superselective nanoparticle targeting (ακ ≈ 3) of αVβ3‐overexpressing endothelial cells. Unlike traditional arginine–glycine–aspartate decorated particles, these fragment‐functionalized LNPs discriminate cells by receptor density and deliver mRNA to ...
Sebastian Bayer +7 more
wiley +2 more sources
HorticulturaeMyrtus communis L. (common myrtle) is an economically valuable Mediterranean shrub with diverse applications in food, pharmaceutical, and ornamental sectors.
Deniz Hazar +7 more
doaj +1 more source
Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1201-1216, September 2026.Unveiling the chemical and biological properties of Litsea cubeba essential oil. ABSTRACT Litsea cubeba essential oil (LCEO) is recognised for its broad spectrum of biological activities, including antimicrobial and insecticidal effects, making it a promising natural alternative to synthetic agents.
Miroslava Kačániová +10 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.Bias‐aware machine learning identified an underexplored imidazolidinone catalyst with broad competitive performance in iminium‐based reactions. Experimental benchmarking shows how data‐driven prioritization can uncover overlooked catalyst scaffolds from sparse and historically biased literature data.
Jiajing Li +4 more
wiley +2 more sources
ChemistryOpen, Volume 15, Issue 9, September 2026.An endemic Aurès chemotype of Salvia balansae emerges as a rich source of luteolin, rosmarinic acid, and other polyphenols with potent antioxidant and NLRP3‐linked anti‐inflammatory activities. Protection against experimental inflammation, favorable enzyme‐modulating properties, and a wide safety margin highlight its promise as a pharmaceutical and ...
Khadra Afaf Bendrihem +16 more
wiley +1 more source
A cryptic allosteric pocket shapes isoform‐selective inhibition of human malic enzymes
Protein Science, Volume 35, Issue 9, September 2026.Abstract Malic enzymes (ME) regulate central carbon metabolism and cellular redox balance, and the mitochondrial isoform ME2 is frequently upregulated in aggressive cancers to support metabolic flexibility and stress resistance. Isoform‐selective inhibition has remained out of reach because the catalytic machinery is essentially invariant across the ...
Ben A. Krinkel +14 more
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.The essential oil of Perovskia abrotanoides Kar. (rich in 1,8‐cineole and camphor) linearly reduced methane production (up to 57.5%) and total protozoa population in sheep rumen fluid in vitro. Simultaneously, it increased microbial biomass production, microbial synthesis efficiency and the partitioning factor, indicating improved rumen energy ...
Mohsen Kazemi
wiley +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Four series of 20 (het)aryl substituted 7‐deazapurine nucleobases were synthesized. Several potent antagonists of all four subtypes of adenosine receptors were identified by functional assay. High‐throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6‐diaryl‐7 ...
Ugnė Šinkevičiūtė +9 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva +10 more
wiley +1 more source
AgronomyOriganum vulgare L. (Lamiaceae) is widely used in the food, pharmaceutical, perfumery, and cosmetic industries for the needs for which this raw material is cultivated. O.
Ain Raal +4 more
doaj +1 more source