Results 121 to 130 of about 14,379 (215)

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

The combined influence of microbiome and soil environment contributes to the chemotype differentiation in Atractylodes lancea

iMetaOmics
Atractylodes lancea, a traditional Chinese medicinal herb, is divided into two chemotypes based on the production of volatile bioactive compounds: the geo‐authentic Maoshan chemotype (MSA, rich in atractylon and atractylodin) and the non‐authentic Hubei ...
Hongyang Wang, Zheng Peng, Chengcai Zhang, Chuanzhi Kang, Yan Zhang, Xiuzhi Guo, Yiheng Wang, Guang Yang, Zengxu Xiang, Li Zhou, Zhixian Jing, Dahui Liu, Sheng Wang, Luqi Huang, Lanping Guo   +14 more
doaj   +1 more source

Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches

We report the development and application of different strategies for the late-stage functionalization (LSF) of the biologically relevant 4-amino-2-pyridone chemotype.
Longo, Matteo, Radi, Marco, Giannessi, Lisa, Massera, Chiara   +3 more
core   +1 more source

Comparative Analysis of Chemical Composition and Antibacterial Activity of Artemisia argyi and Artemisia lavandulifolia Hydrosols

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
ABSTRACT Hydrosols from Artemisia argyi and A. lavandulifolia collected across different regions and seasons in Shandong Province, China, were comparatively analyzed for chemical composition and antibacterial activity. GC–MS results showed that A. lavandulifolia hydrosol contained higher levels of terpinen‐4‐ol and α‐terpineol and exhibited a chemical ...
Xiaoqing Gao, Yuxin Li, Ting Fang, Wenjie Jiang   +3 more
wiley   +1 more source

Yield, Composition, and Chemotypes of Essential Oils from Origanum vulgare L. Aerial Parts Cultivated in Different European Countries

Agronomy
Origanum vulgare L. (Lamiaceae) is widely used in the food, pharmaceutical, perfumery, and cosmetic industries for the needs for which this raw material is cultivated. O.
Ain Raal, Tetiana Gontova, Anu Ivask, Anne Orav, Oleh Koshovyi   +4 more
doaj   +1 more source

ROLE OF CHEMOTYPE IN AGGRESSIVENESS, TOXICITY, AND COMPETITIVE-NESS OF FUSARIUM GRAMINEARUM ON WHEAT

Fusarium Head Blight (FHB) of wheat, caused by the fungus Fusarium graminearum, is a devastating disease that led to epidemics in the U.S. during the 1990s, resulting in economic losses exceeding $2.6 billion.
Goyal, Simran
core   +1 more source

Seasonal and Regional Variation of the Chemical Composition and Antimicrobial Activity of Essential Oils From Piper marginatum Jacq.

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Evaluating Piper marginatum essential oils across three Brazilian biomes reveals significant chemical and antimicrobial variations driven by seasonal and regional factors. Sixty compounds are identified, including a novel (Z)‐phenylpropanoid reported for the first time. Multivariate analysis correlates environmental stressors with specialized metabolic
Rebeca Gabriel de Camargo, Marta Cristina Teixeira Duarte, Diones Krinski, Ana Paula Palaro Klein Hendges, Aurea Portes Ferriani, Francisco de Assis Marques, Thalita Gilda Santos, Beatriz Helena Lameiro de Noronha Sales Maia   +7 more
wiley   +1 more source

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Computational drug discovery integrates molecular docking, molecular dynamics simulations, and translational clinical targeting to identify next‐generation therapeutics that overcome endocrine resistance in ER‐positive breast cancer. Combined with multi‐omics, artificial intelligence, and biomarker‐guided precision oncology, these approaches accelerate
Emmanuel Ifeanyi Obeagu, Yaregal Asres
wiley   +1 more source

Association of mating-type with mycelium growth rate and genetic variability of Fusarium culmorum

Open Life Sciences, 2013
Irzykowska Lidia, Bocianowski Jan, Baturo-Cieśniewska Anna   +2 more
doaj   +1 more source

Receptores de dopamina y heterómeros de receptores de dopamina en la modulación de la neurotransmisión [PDF]

, 2012
[spa] La mayoría de los ligandos de GPCR que actúan como agonistas, antagonistas o agonistas inversos, se unen al mismo dominio del receptor reconocido por los agonistas endógenos, es decir, el lugar de unión ortostérico.
González González, Sergio
core