Results 131 to 140 of about 12,690 (274)

Chemotypic Diversity and Integrated Metabolic Profiling of Myrtle (Myrtus communis L.) from Mediterranean Turkey

Horticulturae
Myrtus communis L. (common myrtle) is an economically valuable Mediterranean shrub with diverse applications in food, pharmaceutical, and ornamental sectors.
Deniz Hazar, Esra Gölcü, Aydın Mızrak, Doğan Ergün, Luca Mazzoni, Ebru Kafkas, Esra Alim, Sevinç Ateş   +7 more
doaj   +1 more source

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4528-4545, July 2026.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song, Di Liu, Shi Chen, Yufeng Tan, Siyu Wang, Shihan Li, Yutong Qin, Guofeng Li, Xufang Tian, Lan Yang, Chong Yuan, Junbo Gou, Wei Huang, Shilin Chen, Yifei Liu   +14 more
wiley   +1 more source

What is a plant chemotype anyway?

Many plant species show chemical polymorphisms regarding the composition of specialized metabolites belonging to certain chemical families. This led to the classification of chemotypes, that is, groups of plants that can be distinguished by their chemical profiles of metabolites within one chemical family. We present existing definitions and approaches
Caroline Müller, Thomas Dussarrat, Nicole van Dam   +2 more
openaire   +1 more source

Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti, Jennifer A. Miles, George J. Wade, Scott Grossman, George W. Preston, Richard Bayliss, Stuart L. Warriner, Megan H. Wright, Adam Nelson   +8 more
wiley   +1 more source

Genotype to Chemotype Analysis in Sage (Salvia officinalis L., Lamiaceae)

, 2015
Chemotypes (or chemovars) are chemically distinct entities within a plant species based on genetic variation. Their occurrence is in mono- and sesquiterpenes (principal constituents of essential oils) exceptionally frequent.
MAGGI, Filippo
core  

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Screening a lysine‐targeting covalent fragment library against challenging protein targets revealed suitable warheads and characterized binding sites for the development of targeted covalent ligands. Covalent fragment screening has become an established strategy for identifying targetable amino acid residues or viable chemical starting points against ...
Noémi Csorba, Péter Ábrányi‐Balogh, Zoltán Orgován, Tibor Viktor Szalai, György G. Ferenczy, Levente Kollár, Nikolett Péczka, Tímea Imre, József Simon, Pál Szabó, Gitta Schlosser, Martina Hrast, Stanislav Gobec, Varbina Ivanova, Carles Galdeano, Aleksandra Kopranovic, Marc Neumann, Franz‐Josef Meyer‐Almes, György Miklós Keserű   +18 more
wiley   +1 more source

Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches

We report the development and application of different strategies for the late-stage functionalization (LSF) of the biologically relevant 4-amino-2-pyridone chemotype.
Longo, Matteo, Radi, Marco, Giannessi, Lisa, Massera, Chiara   +3 more
core   +1 more source

Development of a Brain‐Penetrant Nurr1 Agonist Tool

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Nuclear receptor‐related 1 (Nurr1) is a ligand‐activated transcription factor with neuroprotective properties, thought to hold therapeutic potential in neurodegeneration. Here, we developed a potent, brain‐penetrant Nurr1 agonist to study the effects of pharmacological Nurr1 activation in the CNS in vivo. The ligand‐sensing transcription factor nuclear
Jan Vietor, Tanja Stiller, Christian Gege, Wael Saeb, Úrsula López‐García, Hella Kohlhof, Daniel Vitt, Daniel Merk   +7 more
wiley   +1 more source

ROLE OF CHEMOTYPE IN AGGRESSIVENESS, TOXICITY, AND COMPETITIVE-NESS OF FUSARIUM GRAMINEARUM ON WHEAT

Fusarium Head Blight (FHB) of wheat, caused by the fungus Fusarium graminearum, is a devastating disease that led to epidemics in the U.S. during the 1990s, resulting in economic losses exceeding $2.6 billion.
Goyal, Simran
core   +1 more source

Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa, Nina‐Louisa Efrém, Feng Li, Ziqiong Guo, Yvette Roske, Katrin Jana Frank, Szymon Pach, Clemens Alexander Wolf, Feng Bo, Marina Lesina, Mika Kintzel, Rana Alsalim, Victoria Zeitz, Noémi Csorba, Silke Radetzki, György M. Keserű, Oliver Daumke, Hana Algül, Gerhard Wolber, Jia Li, Marc Nazaré   +20 more
wiley   +1 more source