Results 201 to 210 of about 19,115 (229)
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Molecular Diversity Assessment using Chemotypes
Current Computer-Aided Drug Design, 2022Background: Many techniques to design chemical libraries for screening have been put forward over time. General use libraries are still important when screening against novel targets, and their design has relied on the use of molecular descriptors. In contrast, chemotype or scaffold analysis has been used less often.
Hugo O. Villar +2 more
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Diaryl Ureas as an Antiprotozoal Chemotype
ACS Infectious Diseases, 2021We now describe the physicochemical profiling, in vitro ADME, and antiparasitic activity of eight N,N'-diarylureas to assess their potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD7.4 values ranged from 2.5 to 4.5; kinetic aq. solubilities were ≤6.3 μg/mL, and plasma protein binding ranged from 95 to 99%.
Derek A. Leas +10 more
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Lipopolysaccharide chemotypes of Burkholderia cepacia
Journal of Medical Microbiology, 1999Burkholderia cepacia is an important pathogen in patients with cystic fibrosis (CF) and much is now known of its epidemiology. In contrast, its virulence mechanisms are poorly understood. The lipopolysaccharide (LPS) of B. cepacia, a well-recognised virulence factor of other gram-negative bacteria, is known to be strongly endotoxic in vitro. The aim of
Elwyn, Evans +2 more
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Chemotypic Variation in Indian Spearmint*
Planta Medica, 1989Our investigation has substantiated that Indian spearmint exists in the form of three chemotypes, the common one being rich in limonene and carvone while the other two being rich in piperitenone ...
L N, Misra, B R, Tyagi, R S, Thakur
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Planta Medica, 1987
According to Scheu (5), a "pure chemical race" is defined using one oil component, which can be unequivocally considered as the main component. However, another way of defining a chemotype is to observe the whole peak distribution of the chromatogram (6).
M, Holopainen +2 more
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According to Scheu (5), a "pure chemical race" is defined using one oil component, which can be unequivocally considered as the main component. However, another way of defining a chemotype is to observe the whole peak distribution of the chromatogram (6).
M, Holopainen +2 more
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New chemotypes for cathepsin K inhibitors
Bioorganic & Medicinal Chemistry Letters, 2008Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.
Naoki, Teno +9 more
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CHEMOTYPES OF FUSOBACTERIUM NUCLEATUM LIPOPOLYSACCHARIDES
Acta Pathologica Microbiologica Scandinavica Section B Microbiology, 1978Lipopolysaccharides (LPS) were isolated from 20 strains of Fusobacterium nucleatum and examined by paper chromatography. gas liquid chromatography and colorimetric methods for the presence of neutral sugars, amino sugars and 2‐keto‐3‐deoxy‐octonate (KDO). The LPS had in common glucosamine, L‐glycero‐D‐manno‐heptose. glucose and KDO. The KDO content was
G, Fredriksen, T, Hofstad
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Chemotyping of yeast mutants using robotics
Yeast, 1999By now, the EUROFAN programme for the functional analysis of genes from the yeast genome has attained its cruising speed. Indeed, several hundreds of yeast mutants with no phenotype as tested by growth on standard media and no significant sequence similarity to proteins of known function are available through the efforts of various laboratories.
K J, Rieger +5 more
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