Results 211 to 220 of about 19,115 (229)

Better than Random? The Chemotype Enrichment Problem

Journal of Chemical Information and Modeling, 2009
Chemotype enrichment is increasingly recognized as an important measure of virtual screening performance. However, little attention has been paid to producing metrics which can quantify chemotype retrieval. Here, we examine two different protocols for analyzing chemotype retrieval: "cluster averaging", where the contribution of each active to the ...
Mark D, Mackey, James L, Melville
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CHEMOTYPES OF VEILLONELLA LIPOPOLYSACCHARIDES

Acta Pathologica Microbiologica Scandinavica Section B Microbiology, 1978
Lipopolysaccharides (LPS) were isolated by phenol‐water extraction from 34 strains of Veillonella. and examined by paper chromatography and colorimetric methods for the presence of neutral sugars, amino sugars and 2‐keto‐3‐deoxy‐octonate (KDO). Several preparations were also examined for neutral sugars by gas liquid chromatography.
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Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype

Bioorganic & Medicinal Chemistry Letters, 2006
Integrase is one of three enzymes expressed by HIV and represents a validated target for therapy. A previous study of the diketoacid-based chemotype suggested that there are two aryl-binding domains on integrase. In this study, modifications to the indole-based diketoacid chemotype are explored.
Michael A, Walker, Timothy, Johnson, Zhuping, Ma, Yunhui, Zhang, Jacques, Banville, Roger, Remillard, Serge, Plamondon, Annapurna, Pendri, Henry, Wong, Daniel, Smith, Albert, Torri, Himadri, Samanta, Zeyu, Lin, Carol, Deminie, Brian, Terry, Mark, Krystal, Nicholas, Meanwell   +16 more
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Function and Chemotypes of Human Hsp70 Chaperones

Current Topics in Medicinal Chemistry, 2016
In humans, Hsp70 chaperones are ubiquitously expressed in the cytosol, endoplasmic reticulum and mitochondria. They fulfill important roles in protein folding and the protection of cells from stress. Different forms of Hsp70 have also been found to regulate specific signaling pathways, many related to cell death.
Liza, Shrestha, Jason C, Young
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Halimium viscosum (Willk) P. Silva, Chemotype Celorico da Beira; the First Portuguese Chemotype

2002
The study of the acid and neutral parts of the n-hexane extract of Halimium viscosum (Celorico da Beira, Portugal), has led to the isolation of known compounds with ent-halimane, valparane and labdane skeleta. Eleven new compounds have been isolated, three ent-halimanes (3, 4, 8), three labdanes (10–11), four valparanes (18, 21, 23, 24) and two ...
D. I. M. De Mendonça, J. M. L. Rodilla, J. G. Urones   +2 more
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Population Structure, Chemotype Diversity, and Potential Chemotype Shifting of Fusarium graminearum in Wheat Fields of Manitoba

Plant Disease, 2008
This study was to investigate the variation of acetyl ester derivative of DON at 15-position oxygen (15ADON) and acetyl ester derivative of DON at 3-position oxygen (3ADON) chemotypes and potential chemotype shifting of Fusarium graminearum based on the population structure of this species in Manitoba.
X W, Guo, W G D, Fernando, H Y, Seow-Brock   +2 more
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Two chemotypes ofScoparia Dulcis in Paraguay

Phytochemistry, 1991
Abstract HPLC analysis of diterpene acids in individual plants of Paraguayan Scoparia dulcis revealed the presence of two chemotypes based on the major component, i.e. scopadulcic acid B type (SDB) and scoparic acid A type (SA). SDB and SA were found to be contained mainly in leaves.
T. Hayashi, K. Okamura, M. Kawasaki, N. Morita   +3 more
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Studies on Chemotypes of Cinnamomum Camphora

Advanced Materials Research, 2011
Gas chromatography coupled with mass spectrometry (GC-MS) was applied to analyze the essential oil extracted from the leaves of 50 individual plants of Cinnamomum camphora, which were collected from the same mountain in Jiangxi province of China. 32 peaks in total were identified in these samples, which were then categorized into five chemotypes ...
Yong Ming Luo, Shi Rong Li, Xiao Yin Yin
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Chemotype diversity of Psidium guajava L.

Phytochemistry, 2018
The essential oil of Psidium guajava L. has been studied for pharmacological and industrial purposes, without considering the plant's genotype regarding the heterogeneity of its composition. The present study aimed to characterize the chemotype diversity of the essential oil extracted from the leaves of 22 genotypes of P. guajava grown in two different
Tércio da Silva, de Souza, Marcia Flores da Silva, Ferreira, Luciano, Menini, Jaqueline Rodrigues Cindra de Lima, Souza, Carolina de Oliveira, Bernardes, Adésio, Ferreira   +5 more
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Chemotypes of Tansy in Finland

Planta Medica, 1986
M, Holopainen, R, Hiltunen, M, V Schantz
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