Results 1 to 10 of about 20,810 (232)

Investigation of the mechanism of chenodeoxycholic acid in treating acute lung injury through network pharmacology and experimental validation [PDF]

Scientific Reports
Network pharmacology and molecular simulation techniques were employed to predict the potential targets and signaling pathways of chenodeoxycholic acid in the treatment of acute lung injury. Subsequently, its therapeutic effects on acute lung injury were
Chong He, Mengmeng Jiang, Qian Xiong, Zuoxi Huang   +3 more
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Microwave synthesis of novel chenodeoxycholic acid esters and comparative study of chromatographic behavior and lipophilicity

Macedonian Journal of Chemistry and Chemical Engineering, 2023
In this study, eco-friendly microwave-assisted esterification reactions of chenodeoxycholic acid with medium-chain diols (1,2-ethanediol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) or tetraethylene glycol were accomplished. The
Ksenija Pavlović, Ljubica Grbović, Milica Karadžić Banjac, Strahinja Kovačević, Anamarija Mandić, Sanja Podunavac-Kuzmanović, Bojana Vasiljević   +6 more
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Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
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Formation of ursodeoxycholic acid from chenodeoxycholic acid in the human colon: studies of the role of 7-ketolithocholic acid as an intermediate.

Journal of Lipid Research, 1983
The formation of ursodeoxycholic acid from chenodeoxycholic acid and the role of 7-ketolithocholic acid as an intermediate in this biotransformation were studied in vitro in fecal incubations as well as in vivo in the human colon.
H Fromm, R P Sarva, F Bazzoli
doaj   +1 more source

Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota

Biomolecules, 2022
Gut microbes have been recognized to convert human bile acids by deconjugation, dehydroxylation, dehydrogenation, and epimerization of the cholesterol core, but the ability to re-conjugate them with amino acids as an additional conversion has been ...
Carlos J. Garcia, Vit Kosek, David Beltrán, Francisco A. Tomás-Barberán, Jana Hajslova   +4 more
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Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]

, 2004
Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Fischer, S., Jungst, C., Jungst, D., Parhofer, K. G., Sauter, G. H., Thiessen, K.   +5 more
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Metabolism of potential precursors of chenodeoxycholic acid in cerebrotendinous xanthomatosis (CTX).

Journal of Lipid Research, 1979
In patients with cerebrotendinous xanthomatosis (CTX), diminished cholic acid production is associated with incomplete oxidation of the cholesterol side chain and the excretion of C(25)-hydroxy bile alcohols.
G Salen, S Shefer, E H Mosbach, S Hauser, B I Cohen, G Nicolau   +5 more
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Metabolism of 7 beta-alkyl chenodeoxycholic acid analogs and their effect on cholesterol metabolism in hamsters.

Journal of Lipid Research, 1990
The metabolism of 7-ethyl- and 7-propyl-chenodeoxycholic acids was studied in hamsters. Both bile acid analogs were absorbed efficiently by the intestine and secreted into the bile at rates similar to those of chenodeoxycholic acid.
M Une, K Yamanaga, EH Mosbach, K Tsujimura, T Hoshita   +4 more
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Experimental isovalthinuria. III. Induction by bile acids, and hypocholesterolemic agents [PDF]

, 1963
Some bile acids (dehydrocholic, cholic, chenodeoxycholic, ursodeoxycholic, and deoxycholic acids), and some hypocholesterolemic agents (22, 25 diazacholestanol, 20,25-diazacholesterol, triparanol, and SKF 525-A) are the inducers of isovalthinuria in ...
Ubuka, Toshihiko
core   +1 more source

Purification of Hyodeoxycholic Acid and Chenodeoxycholic Acid from Pig Bile Saponification Solution Using Column Chromatography [PDF]

Chemical and Biochemical Engineering Quarterly
The purpose of this study was to purify hyodeoxycholic acid and chenodeoxycholic acid from pig bile saponification solution using column chromatography. The optimal resin was selected through static adsorption experiments.
B. Liu, T. Chen, X. Chen, X. Li, K. Abudureheman, S. Hu, X. Gong   +6 more
doaj   +1 more source