Pharmacology of Chenodeoxycholic Acid
Gastroenterology, 1977 Studies on the absorption and metabolism of chenodeoxycholic (chenic) acid were carried out in healthy volunteers as well as gallstone patients on maintenance therapy with chenic acid for gallstone dissolution. Preliminary studies showed that chenic acid was completely absorbed in doses up to 400 mg when infused as a micellar solution into the jejunum,
G.P. van Berge-Henegouwen +1 more
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Investigation of the mechanism of chenodeoxycholic acid in treating acute lung injury through network pharmacology and experimental validation [PDF]
Scientific ReportsNetwork pharmacology and molecular simulation techniques were employed to predict the potential targets and signaling pathways of chenodeoxycholic acid in the treatment of acute lung injury. Subsequently, its therapeutic effects on acute lung injury were
Chong He +3 more
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Metabolism of potential precursors of chenodeoxycholic acid in cerebrotendinous xanthomatosis (CTX).
Journal of Lipid Research, 1979 In patients with cerebrotendinous xanthomatosis (CTX), diminished cholic acid production is associated with incomplete oxidation of the cholesterol side chain and the excretion of C(25)-hydroxy bile alcohols.
G Salen +5 more
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Successful treatment of infantile oxysterol 7α-hydroxylase deficiency with oral chenodeoxycholic acid [PDF]
BMC Gastroenterology, 2021 Background Deficiency of oxysterol 7α-hydroxylase, encoded by CYP7B1, is associated with fatal infantile progressive intrahepatic cholestasis and hereditary spastic paraplegia type 5.
Yun-Ping Tang +5 more
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Gut and Liver, 2015 Background/AimsCholecystectomy is necessary for the treatment of symptomatic or complicated gallbladder (GB) stones, but oral litholysis with bile acids is an attractive alternative therapeutic option for asymptomatic or mildly symptomatic patients. This
Jong Jin Hyun +14 more
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The safety and effectiveness of chenodeoxycholic acid treatment in patients with cerebrotendinous xanthomatosis: two retrospective cohort studies. [PDF]
Neurol Sci, 2020 Verrips A +5 more
europepmc +3 more sources
Macedonian Journal of Chemistry and Chemical Engineering, 2023 In this study, eco-friendly microwave-assisted esterification reactions of chenodeoxycholic acid with medium-chain diols (1,2-ethanediol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, and 1,10-decanediol) or tetraethylene glycol were accomplished. The
Ksenija Pavlović +6 more
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Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]
, 2020 In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco +4 more
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Production of New Microbially Conjugated Bile Acids by Human Gut Microbiota
Biomolecules, 2022 Gut microbes have been recognized to convert human bile acids by deconjugation, dehydroxylation, dehydrogenation, and epimerization of the cholesterol core, but the ability to re-conjugate them with amino acids as an additional conversion has been ...
Carlos J. Garcia +4 more
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Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]
, 2004 Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Fischer, S. +5 more
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