Results 91 to 100 of about 2,513,768 (223)

Evaluation of the effect of chenodeoxycholic acid treatment skeletal system findings in patients with cerebrotendinous xanthomatosis

, 2019
Aim: The primary purpose of the present study is to evaluate the effect of chenodeoxycholic acid treatment on skeletal system findings in patients with cerebrotendinous ...
Cansever, Mehmet Serif, Zubarioglu, Tanyel, Bilen, Inci Pinar, Dogan, Beyza Belde, Enver, Ece Oge, Zeybek, Ayse Cigdem Aktuglu, Kiykim, Ertugrul   +6 more
core   +1 more source

Pharmacy Compounded Medicines for Patients With Rare Diseases: Lessons Learned From Chenodeoxycholic Acid and Cholic Acid

, 2021
Patients with rare diseases are often confronted with the fact that effective medicines are unavailable or simply not being developed. This situation jeopardizes the health of a large population of vulnerable patients with rare diseases.
Jacobs, Bart A. W., Kemper, E. Marleen, Polak, Yasmin   +2 more
core   +1 more source

Inhibition of formyl peptide receptor-1-mediated cell death as a therapy for lethal cutaneous drug reactions in preclinical models

Nature Communications
Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening mucocutaneous adverse drug reactions characterized by disseminated skin and mucosal detachment.
Haruna Kimura, Akito Hasegawa, Tomoki Nishiguchi, Hong Ha Nguyen, Masatoshi Eguchi, Manao Kinoshita, Youichi Ogawa, Takeaki Ozawa, Riichiro Abe   +8 more
doaj   +1 more source

Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass [PDF]

, 2017
Postprandial secretion of glucagon-like peptide-1 (GLP-1) is enhanced after Roux-en-Y gastric bypass (RYGB), but the precise molecular mechanisms explaining this remain poorly understood. Plasma concentrations of bile acids (BAs) increase after RYGB, and
Svane, Maria S, Holst, Jens J, Viggo B. Kristiansen, Signe Nielsen, Rehfeld, Jens F, Jens J. Holst, Bojsen-Moller, Kirstine N, Nielsen, Signe, Trine R. Clausen, Sten Madsbad, Jens F. Rehfeld, Maria S. Svane, Kirstine N. Bojsen-Moller, Clausen, Trine R, Rune E. Kuhre, Kuhre, Rune E, Kristiansen, Viggo B, Madsbad, Sten   +17 more
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Quantitative aspects of the interaction of bile acids with human serum albumin.

Journal of Lipid Research, 1982
The interaction of human serum albumin with twelve bile acids (ba) has been studied by equilibrium dialysis technique using 3H- and 14C-labeled bile acids.
A Roda, G Cappelleri, R Aldini, E Roda, L Barbara   +4 more
doaj   +1 more source

Biotransformation of chenodeoxycholic acid by Pseudomonas species NCIB 10590 under anaerobic conditions.

Journal of Lipid Research, 1983
The metabolism of chenodeoxycholic acid by Pseudomonas sp. NCIB 10590 under strict anaerobic conditions was studied. A range of unsaturated acidic and neutral metabolites were isolated and identified.
R W Owen, M J Hill, R F Bilton
doaj   +1 more source

CYCLOSPORINE-A BLOCKS BILE-ACID SYNTHESIS IN CULTURED-HEPATOCYTES BY SPECIFIC-INHIBITION OF CHENODEOXYCHOLIC ACID SYNTHESIS

, 1991
Bile acid synthesis, determined by conversion of [4-C-14]cholesterol into bile acids in rat and human hepatocytes and by measurement of mass production of bile acids in rat hepatocytes, was dose-dependently decreased by cyclosporin A, with 52% (rat) and ...
KUIPERS, F, VONK, RJ, PRINCEN, HMG, KUIPERS, F; id_orcid, WOLTHERS, BG   +4 more
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7‑Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency

, 2019
TGR5 agonists are potential therapeutics for a variety of conditions including type 2 diabetes, obesity, and inflammatory bowel disease. After screening a library of chenodeoxycholic acid (CDCA) derivatives, it was determined that a range of ...
Alexander Khoruts (846836), Kristen L. Stoltz (2864585), Ali Nakhi (6910979), Jon E. Hawkinson (1277559), Peter I. Dosa (795666), Kristen John (381275), Elizabeth A. Ambrose (6910985), Michael J. Sadowsky (147063), Connor M. McDermott (6910982)   +8 more
core   +2 more sources

Measurement of sulfated and nonsulfated bile acids in human serum and urine

Journal of Lipid Research, 1974
Amberlite XAD-2 was used to extract bile acids from urine or diluted serum of patients with hepatobiliary diseases. Columns containing Sephadex LH-20 were then used to separate the sulfated and nonsulfated bile acids.
Isao Makino, Kenjiro Shinozaki, Shoichi Nakagawa, Keimei Mashimo   +3 more
doaj   +1 more source

Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis

, 1991
Bile acid synthesis, determined by conversion of [4-14C]cholesterol into bile acids in rat and human hepatocytes and by measurement of mass production of bile acids in rat hepatocytes, was dose-dependently decreased by cyclosporin A, with 52% (rat) and ...
Meijer, P., Wolthers, B.G., Vonk, R.J., Princen, H.M.G., Kuipers, F.   +4 more
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