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Nutrition & DiabetesBackground Diabetic kidney disease (DKD) is the major complication of diabetes concomitant with gut dysbiosis and glycometabolic disorder, which are strongly associated with bile acid (BA) metabolism. Yet studies investigating the BA metabolism involving
Qing Zhang +6 more
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Pharmacology of Chenodeoxycholic Acid
Gastroenterology, 1977 G.P. van Berge-Henegouwen, A.F. Hofmann
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Hypertriglyceridaemia and Chenodeoxycholic Acid
1977Abnormalities of lipoprotein metabolism are frequently found in patient with primary gout. The most common lipid abnormality is hypertriglyceridaemia, independent of, and not secondary to, either obesity, alcohol consumption, or carbohydrate intolerance (1,2).
R, Marcolongo, A, Debolini
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TREATMENT OF GALLSTONES BY CHENODEOXYCHOLIC ACID
Medical Journal of Australia, 1980Twenty-three patients with radiolucent gallstones in a functioning gallbladder were treated by orally administered chenodeoxycholic acid (750 mg/day) for periods ranging from six to 24 months. Complete dissolution of gallstones occurred in five patients, and partial dissolution occurred in four patients--an over-all response of 39%. Side effects of the
J, Toouli, P, Jablonski, J M, Watts
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Solvolysis of chenodeoxycholic acid sulfates
Steroids, 1981Chemical solvolysis of chenodeoxycholic acid sulfates was studied using 4 published methods. Quantitative recovery of chenodeoxycholic acid from the 3-sulfate was obtained with each method. However, only 2 methods yielded chenodeoxycholic acid after solvolysis of the 7-sulfate.
B I, Cohen, K, Budai, N B, Javitt
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Metabolism of chenodeoxycholic acid in hamsters
Lipids, 1976AbstractThe study on the metabolism after oral administration of chenodeoxycholic acid‐24‐14C was performed by analysis of radioactivity that had appeared in bile and feces of male hamsters. The radioactive bile acids were analyzed by thin layer chromatography and identified by the isotope dilution method. In the bile of the hamsters with bile fistula,
T, Tateyama, K, Katayama
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Structure of chenodeoxycholic acid in chenodeoxycholic acid ethyl acetate solvate
Acta Crystallographica Section C Crystal Structure Communications, 1990C 24 H 40 O 4 •C 4 H 8 O 2 cristallise dans P6 5 avec a=22,169, c=10,226 A, Z=6; affinement jusqu'a R=0,071. Les molecules acides chenodesoxycholiques sont arrangees en une chaine helicoidale autour de l'axe 6 5 , formant ainsi une colonne infinie. Les groupes hydrophiles externes de ces colonnes sont empiles parallelement l'un a l'autre et connectes
P. van der Sluis +2 more
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Chenodeoxycholic Acid: Uses and Limitations
Hospital Practice, 1979Conclusions about the efficacy and safety of this agent for dissolving cholesterol gallstones must wait until late next year, when results of large clinical trials are available. But results from many studies are available, as are preliminary clinical data from trials of a possible alternative, ursodeoxycholic acid.
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Chenodeoxycholic Acid and Ursodeoxycholic Acid
1990Cholelithiasis (gallstones) is a major medical and economic problem in the USA (Schoenfield, 1977; Schoenfield et al., 1981). It has been estimated to have a prevalence of 15 million women and five million men, and almost one million new cases are discovered each year (Ingelfinger, 1968; Friedman et al., 1966).
Robert A. Maxwell, Shohreh B. Eckhardt
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